1
Richard N Zare, Ernst Gassmann: Laser-excitation fluorescence detection electrokinetic separation. The Board of Trustees of the Leland Stanford Junior University, Ciotti & Murashige, June 23, 1987: US04675300 (180 worldwide citation)

An electrokinetic process and apparatus employing coherent radiation-excited fluorescence for detection is disclosed. In a preferred embodiment, the support liquid is a chiral liquid and the process is employed to separate and detect the separation of optical isomers.


2
Jonathan V Sweedler, Jason B Shear, Richard N Zare: Method and device employing time-delayed integration for detecting sample components after separation. The Trustees of the Leland Stanford Junior University, Majestic Parsons Siebert & Hsue, August 25, 1992: US05141609 (108 worldwide citation)

This invention relates to a detection method and apparatus useful in capillary electrophoresis and capillary chromatography that employs an array of solid state detector such as a charge-coupled device operating in the time-delayed integration mode which allows more exposure time of the moving analy ...


3
Evan R Williams, Richard N Zare: Surface induced dissociation with reflectron time-of-flight mass spectrometry. Majestic Parsons Siebert & Hsue, September 1, 1992: US05144127 (68 worldwide citation)

Surface induce dissociation (SID) in a reflectron tandem time-of-flight mass spectrometer is demonstrated using a movable "in-line" SID surface in the reflectron lens. For collisions under 100 eV, SID spectra are measured with a resolution of .about.65 (FWHM) with dissociation efficiencies of 7-15% ...


4
David J Rakestraw, Deon S Anex, Chao Yan, Rajeev Dadoo, Richard N Zare: Electro-osmotically driven liquid delivery method and apparatus. Sandia Corporation, Timothy Evans, Kurt Olsen, August 24, 1999: US05942093 (63 worldwide citation)

Method and apparatus for controlling precisely the composition and delivery of liquid at sub-.mu.L/min flow rate. One embodiment of such a delivery system is an electro-osmotically driven gradient flow delivery system that generates dynamic gradient flows with sub-.mu.L/min flow rates by merging a p ...


5
Richard N Zare, Friedrich Engelke, Jong H Hahn: Apparatus and method for laser desorption of molecules for quantitation. The Board of Trustees of the Leland Stanford Junior College, Majestic Parsons Siebert & Hsue, January 29, 1991: US04988879 (60 worldwide citation)

A method and device for volatilizing and thereafter ionizing quantitatable femtomole and smaller amounts of molecules of nonvolatile solid oranic materials is disclosed. The method and device employ a laser pulse to desorb the organic material from a support upon which it is physisorbed. The support ...


6
Richard N Zare, Juergen Martin, Barbara A Paldus, Jinchun Xie: Ring resonant cavities for spectroscopy. The Board of Trustees of the Leland Stanford Junior University, Lumen Intellectual Property Services, June 15, 1999: US05912740 (58 worldwide citation)

Ring-shaped resonant cavities for spectroscopy allow a reduction in optical feedback to the light source, and provide information on the interaction of both s- and p-polarized light with samples. A laser light source is locked to a single cavity mode. An intracavity acousto-optic modulator may be us ...


7
Ansgar Brock, Nestor Rodriguez, Richard N Zare: Time-of-flight mass spectrometer and ion analysis. Board of Trustees of the Leland Stanford Junior University, James S Hsue, Skjerven Morrill MacPherson, October 9, 2001: US06300626 (49 worldwide citation)

An ion beam supplied from a source is modulated so that ions at a constant flux is passed during on periods or portions thereof and are deflected or stopped during off periods according to a binary sequence in order to encode the ion beam with phase information of the sequence. The binary sequence i ...


8
Jason B Shear, Rajeev Dadoo, Harvey A Fishman, Neil Shafer, Richard N Zare: System for sample detection with compensation for difference in sensitivity to detection of components moving at different velocities. The Board of Trustees of the Leland Stanford Junior University, Majestic Parsons Siebert & Hsue, April 2, 1996: US05503994 (44 worldwide citation)

In many separation techniques, such as field flow fractionation, liquid chromatography and electro-phoresis, chemical species form bands that migrate at different velocities. If the data-digitization rate and excitation intensity are both set to be optimal for the fastest migrating band, to compensa ...


9
Richard N Zare, Maria T Dulay, Joselito P Quirino, Bryson Bennett: Photopolymerized sol-gel column and associated methods. The Board of Trustees of the Leland Stanford Junior University, Parsons Hsue & de Runtz, March 15, 2005: US06866785 (43 worldwide citation)

A separation column and a method of making the separation column are provided. The separation column includes a separation channel and fritless separation medium in the channel. The separation medium includes a porous matrix, and the porous matrix includes a metal organic polymer, such as a photopol ...


10
Richard N Zare, Maria T Dulay, Joselito P Quirino, Bryson Bennett: Bonded phase photopolymerized sol-gel column and associated methods. The Board of Trustees of the Leland Stanford Junior University, Parsons Hsue & de Runtz, April 26, 2005: US06884346 (43 worldwide citation)

A separation column and a method of making the separation column are provided. The separation column includes a separation channel and a separation medium in the channel. The separation medium includes a porous matrix, and the porous matrix includes a support and a stationary phase. The support incl ...