1
Thomas R Tice, Richard M Gilley: Drug delivery system and method of making the same. Southern Research Institute, Needle & Rosenberg, January 30, 1990: US04897268 (262 worldwide citation)

A compatible, biodegradable microcapsule delivery system for active ingredients, including hormonally active peptides, proteins, or other bioactive molecules, and a method of making the same. The ingredients are encapsulated in biodegradable copolymer excipients of varying mole ratios and the blend ...


2
Thomas R Tice, Richard M Gilley, John H Eldridge, Jay K Staas, Melinda G Hollingshead, William M Shannon: Method of potentiating an immune response. Southern Research Institute, UAB Research Foundation, Needle & Rosenberg, December 24, 1991: US05075109 (232 worldwide citation)

A method of delivering a bioactive agent to an animal entailing the steps of encapsulating effective amounts of the agent in a biocompatible excipient to form microcapsules having a size ranging from between approximately one micrometer to approximately ten micrometers and admnistering effective amo ...


3
Thomas R Tice, Richard M Gilley: Microencapsulation process and products therefrom. Southern Research Institute, Needle & Rosenberg, April 18, 1995: US05407609 (198 worldwide citation)

A method of microencapsulating an agent to form a microencapsulated product, having the steps of dispersing an effective amount of the agent in a solvent containing a dissolved wall forming material to form a dispersion, combining the dispersion with an effective amount of a continuous process mediu ...


4
Robert N Boyes, Thomas R Tice, Richard M Gilley, Kenneth L Pledger: Pharmaceutical formulations comprising microcapsules. Innovata Biomed, Harness Dickey & Pierce, January 24, 1995: US05384133 (150 worldwide citation)

Pharmaceutical formulations comprise (i) microcapsules which consist essentially of a biocompatible polymeric wall material encapsulating a drug, and (ii) a lipid soluble surfactant which is mixed with the microcapsules or is incorporated within or coats the wall material of the microcapsules. Such ...


5
Thomas R Tice, William E Meyers, Richard M Gilley, William M Shannon: Long-acting biocidal compositions and method therefor. Southern Research Institute, Hopgood Calimafde Kalil Blaustein & Judlowe, April 29, 1986: US04585482 (122 worldwide citation)

There is disclosed, in one aspect, a long-acting biocidal composition. This composition comprises a chlorine dioxide-liberating compound, such as sodium chlorite, and sufficient organic acid-generating compound, such as poly(lactic acid), to lower the pH of the composition to less than about 7. The ...


6
Thomas R Tice, Richard M Gilley, John H Eldridge, Jay K Staas: Method for delivering bioactive agents into and through the mucosally-associated lymphoid tissues and controlling their release. Southern Research Institute, The UAB Research Foundation, Needle & Rosenberg, August 24, 1999: US05942252 (84 worldwide citation)

A method, and compositions for use therein capable, of delivering a bioactive agent to an animal entailing the steps of encapsulating effective amounts of the agent in a biocompatible excipient to form microcapsules having a size less than approximately ten micrometers and administering effective am ...


7
Thomas R Tice, Richard M Gilley, John H Eldridge, Jay K Staas: Method for delivering bioactive agents into and through the mucosally-associated lymphoid tissues and controlling their release. Southern Research Institute, The UAB Research Foundation, Needle & Rosenberg P C, October 13, 1998: US05820883 (83 worldwide citation)

A method, and compositions for use therein capable, of delivering a bioactive agent to an animal entailing the steps of encapsulating effective amounts of the agent in a. biocompatible excipient to form microcapsules having a size less than approximately ten micrometers and administering effective a ...


8
Maninder Singh, Jack H Nunberg, Thomas R Tice, Michael E Hudson, Richard M Gilley, Terrance A Taforo: Controlled-release formulations of interleukin-2. Cetus Corporation, Philip L McGarrigle, Lewis S Gruber, Grant Green, April 7, 1992: US05102872 (68 worldwide citation)

Shipping fever, and other stress-related diseases in livestock, are treated by administration of a microencapsulated composition comprising IL-2 conjugated with a polyoxyethylene polymer, and mixed with a release-modulating amount of humen serum albumin. The microcapsules are administered parenteral ...


9
Thomas R Tice, Richard M Gilley, John H Eldridge, Jay K Staas: Method for delivering bioactive agents into and through the mucosally-associated lymphoid tissue and controlling their release. Southern Research Institute, The UAB Research Foundation, Needle & Rosenberg P C, December 29, 1998: US05853763 (65 worldwide citation)

A method, and compositions for use therein capable, of delivering a bioactive agent to an animal entailing the steps of encapsulating effective amounts of the agent in a biocompatible excipient to form microcapsules having a size less than approximately ten micrometers and administering effective am ...


10
Thomas R Tice, Richard M Gilley, John H Eldridge, Jay K Staas: Method for delivering bioactive agents into and through the mucosally associated lymphoid tissues and controlling their release. Southern Research Institute, The UAB Research Foundation, Needle & Rosenberg P C, September 29, 1998: US05814344 (55 worldwide citation)

A method, and compositions for use therein capable, of delivering a bioactive agent to an animal entailing the steps of encapsulating effective amounts of the agent in a biocompatible excipient to form microcapsules having a size less than approximately ten micrometers and administering effective am ...