1
Richard L Monaghan, Alfred W Alberts, Carl H Hoffman, George Albers Schonberg: Hypocholesteremic fermentation products and process of preparation. Merck & Co, William H Nicholson, Harry E Westlake Jr, November 4, 1980: US04231938 (266 worldwide citation)

Substances isolated after cultivation of a microorganism belonging to the genus Aspergillus in a culture medium comprise a compound designated MSD803 which has the lactone structure: ##STR1## as well as its free hydroxy acid form. Together with salts and esters of the free acid form, these compounds ...


2
George Albers Schonberg, Richard L Monaghan, Alfred W Alberts, Carl H Hoffman: Hypocholesteremic fermentation products. Merck & Co, William H Nicholson, Mario A Monaco, August 3, 1982: US04342767 (35 worldwide citation)

Substances isolated after cultivation of a microorganism belonging to the genus Aspergillus in a culture medium comprise compounds which have structures: ##STR1## Together with salts and esters of the carboxylic acid, these compounds form a class of highly active hypocholesteremic and hypolipemic me ...


3
Richard L Monaghan, Alfred W Alberts, Carl H Hoffman, George Albers Schonberg: Hypocholesteremic fermentation products and process of preparation. Merck & Co, William H Nicholson, Mario A Monaco, October 13, 1981: US04294926 (30 worldwide citation)

Substances isolated after cultivation of a microorganism belonging to the genus Aspergillus in a culture medium comprise a compound designated MSD803 which has the lactone structure: ##STR1## as well as its free hydroxy acid form. Together with salts and esters of the free acid form, these compounds ...


4
Robert A Giacobbe, Sagrario M Del Val, Richard L Monaghan, Robert E Schwartz: Process for antifungal fermentation product. Merck & Co, Alice O Robertson, Charles M Caruso, November 6, 1990: US04968608 (14 worldwide citation)

An antifungal agent produced by cultivation of Zalerion arboricola is a cyclic lipopeptide with very high activity against human pathogens and of very low mammalian toxicity. Its production and isolation are also described.


5
John G MacConnell, Byron H Arison, George A Doss, Richard L Monaghan: Cholesterol lowering compounds. Merck & Co, Catherine A Dolan, Roy D Meredith, Paul D Matukaitis, May 31, 1994: US05317031 (13 worldwide citation)

Cholesterol lowering compounds and compositions are formed from the photochemical treatment of the Zaragozic Acids followed by esterification. These compounds and compositions are active squalene synthetase inhibitors useful in the treatment of hypercholesterolemia.


6
Vincent P Gullo, Tony Y K Lam, Richard L Monaghan: Hypocholesterolemic fermentation products and process of preparation. Merck & Co, William H Nicholson, Mario A Monaco, February 21, 1984: US04432996 (8 worldwide citation)

Substances isolated after cultivation of a micoorganism belonging to the genus Penicillium in a culture medium comprises compounds which have strucures: ##STR1## Together with salts and esters of the carboxylic acid, these compounds form a class of highly active hypocholesterolemic and hypolipemic m ...


7
Richard L Monaghan, Michael A Goetz, Raymond S L Chang: Cholecystokinin antagonists. Merck & Co, Daniel T Szura, Gabriel Lopez, Ernest V Linek, July 23, 1985: US04530790 (7 worldwide citation)

The compound having Formula I and several minor related compounds are produced by the aerobic fermentation of Aspergillus alliaceus Thom and Church, ATCC No. 20655 or ATCC No. 20656. ##STR1## The compound of Formula I and the several minor related compounds are antagonists of cholecystokinin (CCK). ...


8
Vincent P Gullo, Tony Y K Lam, Richard L Monaghan: Hypocholesterolemic fermentation products. Merck & Co, William H Nicholson, Mario A Monaco, August 10, 1982: US04343814 (5 worldwide citation)

Substances isolated after cultivation of a microorganism belonging to the genus Penicillium in a culture medium comprises compounds which have structures: ##STR1## Together with salts and esters of the carboxylic acid, these compounds form a class of highly active hypocholesterolemic and hypolipemic ...


9
Michael A Goetz, Pamela A McCormick, Richard L Monaghan: Antiparasitic macrolide from a strain of Streptomyces hygroscopicus. Merck & Co, David L Rose, Mario A Monaco, June 28, 1983: US04390546 (5 worldwide citation)

There is disclosed a macrolide isolated from the fermentation broth of a microorganism identified as MA-5285 which morphological analysis reveals to be a strain of Streptomyces hygroscopicus. The compound's structure is presented based upon analytical studies. The compound has insecticidal and antip ...


10
Richard L Monaghan: Cholesterol lowering compounds produced by directed biosynthesis. Merck & Co, Catherine A Dolan, Melvin Winokur, Paul D Matukaitis, January 11, 1994: US05278320 (4 worldwide citation)

Compounds of Structural Formula (I) ##STR1## are produced by chemical modification of directed biosynthesis products. These compounds are squalene synthetase inhibitors and thus useful as cholesterol lowering agents, antifungal agents and cancer treatment agents.