1
James D Rodgers, Haisheng Wang, Andrew P Combs, Richard B Sparks: Pyrrolo[2,3-b]pyridin-4-yl-amines and pyrrolo[2,3-b]pyrimidin-4-yl-amines as Janus kinase inhibitors. Incyte Corporation, Fish & Richardson P C, February 26, 2008: US07335667 (46 worldwide citation)

The present invention provides pyrrolo[2,3-b]pyridine-4-yl amines pyrrolo[2,3-b]pyrimidin-4-yl amines that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases and cancer.


2
James D Rodgers, Haisheng Wang, Andrew P Combs, Richard B Sparks: Pyrrolo[2,3-b]pyridin-4-yl-amines and pyrrolo[2,3-b]pyrimidin-5-yl-amines as janus kinase inhibitors. Ineyte Corporation, Fish & Richardson P C, November 8, 2011: US08053433 (39 worldwide citation)

The present invention provides pyrrolo[2,3-b]pyridine-4-yl amines pyrrolo[2,3-b]pyrimidin-4-yl amines that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases and cancer.


3
James D Rodgers, Haisheng Wang, Andrew P Combs, Richard B Sparks: Pyrrolo[2,3-b]pyridin-4-yl-amines and pyrrolo[2,3-b]pyrimidin-5-yl-amines as Janus kinase inhibitors. Incyte Corporation, Fish & Richardson P C, May 21, 2013: US08445488 (30 worldwide citation)

The present invention provides pyrrolo[2,3-b]pyridine-4-yl amines pyrrolo[2,3-b]pyrimidin-4-yl amines that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases and cancer.


4
Argyrios G Arvanitis, James D Rodgers, Andrew P Combs, Richard B Sparks, Darius J Robinson: Azepine inhibitors of Janus kinases. Incyte Corporation, Fish & Richardson P C, October 22, 2013: US08563541 (24 worldwide citation)

The present invention provides compounds that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.


5
James D Rodgers, Haisheng Wang, Andrew P Combs, Richard B Sparks: Pyrrolo[2,3-b]pyridin-4-yl-amines and pyrrolo[2,3-b]pyrimidin-5-yl-amines as Janus kinase inhibitors. Incyte Corporation, Fish & Richardson P C, June 3, 2014: US08741895 (22 worldwide citation)

The present invention provides pyrrolo[2,3-b]pyridine-4-yl amines pyrrolo[2,3-b]pyrimidin-4-yl amines that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases and cancer.


6
Argyrios G Arvanitis, James D Rodgers, Andrew P Combs, Richard B Sparks, Darius J Robinson: Azepine inhibitors of janus kinases. Incyte Corporation, Fish & Richardson P C, September 16, 2014: US08835423 (17 worldwide citation)

The present invention provides compounds that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.


7
Andrew P Combs, Yun Long Li, Eddy W Yue, Richard B Sparks: Substituted heteroaryl fused derivatives as PI3K inhibitors. Incyte Corporation, Fish & Richardson P C, June 24, 2014: US08759359 (14 worldwide citation)

The present invention provides fused derivatives of Formula I: that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PI3Ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other disea ...


8
Andrew P Combs, Eddy W Yue, Richard B Sparks, Wenyu Zhu: 1,2,5-oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase. Incyte Corporation, Fish & Richardson P C, January 3, 2012: US08088803 (13 worldwide citation)

The present invention is directed to 1,2,5-oxadiazole derivatives, and compositions of the same, which are inhibitors of indoleamine 2,3-dioxygenase and are useful in the treatment of cancer and other disorders, and to the processes and intermediates for making such 1,2,5-oxadiazole derivatives.


9
Andrew P Combs, Eddy Wai Tsun Yue, Michael J Bower, Wenyu Zhu, Matthew L Crawley, Richard B Sparks, James R Pruitt, Amy Takvorian: Inhibitors of proteins that bind phosphorylated molecules. Incyte Corporation, Fish & Richardson P C, November 28, 2006: US07141596 (12 worldwide citation)

The present invention provides compounds that can modulate the activity of a target protein, such as a phosphatase, that selectively binds phosphorylated peptides or proteins. The present compounds can be useful in treating diseases or disorders, including, for example, diabetes and obesity, that ar ...


10
Thomas M Bare, Richard B Sparks: Pyridazinedione compounds useful in treating neurological disorders. Imperial Chemical, Michael D Alexander, February 4, 1997: US05599814 (9 worldwide citation)

The present invention relates to pyridazino[4,5-b]quinolines, and pharmaceutically useful salts thereof, which are excitatory amino acid antagonists and which are useful when such antagonism is desired such as in the treatment of neurological disorders. The invention further provides pharmaceutical ...