1
Richard Axel, Michael H Wigler, Saul J Silverstein: Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials. The Trustees of Columbia University, John P White, August 16, 1983: US04399216 (700 worldwide citation)

The present invention relates to processes for inserting DNA into eucaryotic cells, particularly DNA which includes a gene or genes coding for desired proteinaceous materials for which no selective criteria exist. The insertion of such DNA molecules is accomplished by cotransforming eucaryotic cells ...


2
Richard Axel, Michael H Wigler, Saul J Silverstein: Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials. The Trustees of Columbia University in the City of New York, John P White, January 6, 1987: US04634665 (314 worldwide citation)

The present invention relates to processes for inserting DNA into eucaryotic cells, particularly DNA which includes a gene or genes coding for desired proteinaceous materials for which no selective criteria exist. The insertion of such DNA molecules is accomplished by cotransforming eucaryotic cells ...


3
Richard Axel, Michael H Wigler, Saul J Silverstein: Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials. The Trustees of Columbia University in the City of New York, John P White, January 12, 1993: US05179017 (265 worldwide citation)

The present invention relates to processes for inserting DNA into eucaryotic cells, particularly DNA which includes a gene or genes coding for desired proteinaceous materials for which no selective criteria exist. The insertion of such DNA molecules is accomplished by cotransforming eucaryotic cells ...


4
David J Julius, Richard Axel, Thomas M Jessell: DNA encoding serotonin 1C (5HT1c) receptor, isolated 5HT1c receptor, mammalian cells expressing same and uses thereof. The Trustees of Columbia University in the City of New York, John P White, January 15, 1991: US04985352 (62 worldwide citation)

The invention relates to DNA encoding a functional serotonin 5HT1c receptor, e.g., cDNA, and to the isolated, functional serotonin 5HT1c receptor encoded by such DNA. The invention also relates to mammalian cells expressing the cDNA encoding the 5HT1c receptor and to a DNA probe useful for detecting ...


5
Charles R Cantor, Richard Axel, Carlos Argarana: DNA encoding streptavidin, streptavidin produced therefrom, fused polypeptides which include amino acid sequences present in streptavidin and uses thereof. The Trustees of Columbia University in the City of New York, John P White, John J Santalone, June 13, 1989: US04839293 (30 worldwide citation)

DNA which encodes the polypeptide streptavidin has been isolated as a fragment 2 kb in length derived from a restriction endonuclease digestion of the chromosomal DNA of Streptomyces avidinii. The nucleic acid sequence of the gene and the amino acid sequence of the polypeptide have been determined. ...


6
Paul J Maddon, Leonard Chess, Richard Axel, Robin Weiss, Dan R Littman, J Steven McDougal: Soluble forms of the T cell surface protein CD4. The Trustees of Columbia University in the City of New York, John P White, June 30, 1992: US05126433 (19 worldwide citation)

A single-stranded nucleic acid molecule which encodes an amino acid sequence comprising at least a portion of a T4 glycoprotein is provided. Additionally, amino acid sequences which comprise at least a portion of a T4 glycoprotein and are useful as a prophylaxis for treating a subject with acquired ...


7
Richard Axel, James M Roberts: Method for introducing cloned, amplifiable genes into eucaryotic cells and for producing proteinaceous products. Trustees of Columbia University in the City of New York, John P White, September 22, 1992: US05149636 (13 worldwide citation)

Multiple copies of a foreign DNA I coding for the production of a protein may be introduced into eucaryotic cells by cotransforming suitable cells with foreign DNA I and with foreign DNA II which includes a functionally deficient, amplifiable gene coding for a selectable or identifiable trait, prefe ...


8
Richard Axel, Michael H Wigler, Saul J Silverstein: DNA construct for producing proteinaceous materials in eucaryotic cells. The Trustees of Columbia University in the City of New York, John P White, Cooper & Dunham, September 24, 2002: US06455275 (12 worldwide citation)

The invention relates to processes for inserting into eucaryotic cells a multiplicity of DNA molecules which includes genes coding for desired proteinaceous materials. The insertion of multiple copies of desired genes is accomplished by cotransformation with the desired genes and with amplifiable ge ...


9
Paul J Maddon, Richard Axel, Raymond W Sweet, James Arthos: Derivatives of soluble T-4. The Trustees of Columbia University in the City of New York, Smithkline Beckman Corporation, John P White, Antoinette F Konski, May 5, 1992: US05110906 (11 worldwide citation)

This invention provides a therapeutic agent capable of specifically forming a complex with human immunodeficiency virus envelope glycoprotein which comprises a polypeptide. In one embodiment of the invention, the amino acid sequence of the polypeptide comprises the amino acid sequence shown in FIG. ...


10
Haglund Richard Axel, Tupack Robert Edward: Cooling cabins of parked aircraft. Teledyne, June 26, 1985: GB2150278-A (11 worldwide citation)

A system 10 for cooling aircraft passenger cabins is located external to the aircraft and comprises a cooling unit 14, a heat exchanger 16 and a blower 18 which reduce the temperature of the air at outlet 22 to such a level that the air entering the aircraft inlet is below 35 DEG F. The air leaves t ...