1
Richard B Bailey, Dilip K Joshi, Stephen L Michaels, Richard A Wisdom: Production of lactic acid by continuous fermentation using an inexpensive raw material and a simplified method of lactic acid purification. Neurex, Flehr Hohbach Test Albritton & Herbert, September 13, 1988: US04771001 (50 worldwide citation)

The disclosure describes a method for producing lactic acid from carbohydrate-containing media by continuous fermentation utilizing particular methods of media pretreatment, cell-recycle fermentation, fermentation broth acidification, and lactic acid separation.


2
Richard B Bailey, Dilip K Joshi, Stephen L Michaels, Richard A Wisdom: Production of lactic acid by continuous fermentation using an inexpensive raw material and a simplified method of lactic acid purification. Engenics, Flehr Hohbach Test Albritton & Herbert, October 6, 1987: US04698303 (38 worldwide citation)

The invention provides a method for producing lactic acid by continuous fermentation utilizing particular methods of media pretreatment, cell-recycle fermentation, fermentation broth acidification, and lactic acid separation.


3
Christopher T Evans, Richard A Wisdom: Bicarbonate assay and phosphoenolpyruvate carboxylase enzyme from hyphomicrobium. Genzyme, Foley & Lardner, May 7, 1996: US05514538 (2 worldwide citation)

Phosphoenolpyruvate carboxylase (PEPC) characterized by a specific activity of at least 40 units/mg; and/or by no more than 50% loss of activity after 60 days in 167 mM Tricine/HCl buffer, pH 8.0, and 15 mM MgCl.sub.2 ; and/or, at pH 6.5, an activity of at least 40% relative to the activity at optim ...


4
Chriatopher T Evans, Richard A Wisdom, Peter J Stabler, Germano Carganico: Ketoprofen resolution by ester hydrolysis using Trichosporon laibacchii. Laborabotios Menarini, Oblon Spivak McClelland Maier & Neustadt, May 14, 1996: US05516690 (2 worldwide citation)

Arylalkanoic acids are produced by biotransformation using suitable microorganisms and, in particular, (S)-ketoprofen in greater than 95% purity from racemic ketoprofen ethyl ester.



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