1
Richard A Mathies, Konan Peck: Laser excited confocal microscope fluorescence scanner and method. The Regents of the University of California, Flehr Hohbach Test Albritton & Herbert, February 25, 1992: US05091652 (309 worldwide citation)

A fluorescent scanner for scanning the fluorescence from a fluorescence labeled separated sample on a sample carrier including a confocal microscope for illuminating a predetermined volume of the sample carrier and/or receiving and processing fluorescence emissions from said volume to provide a disp ...


2
Richard A Mathies, Adam T Woolley: Miniature reaction chamber and devices incorporating same. The Regents of the University of California, Townsend and Townsend and Crew, October 17, 2000: US06132580 (204 worldwide citation)

The present invention generally relates to miniaturized devices for carrying out and controlling chemical reactions and analyses. In particular, the present invention provides devices which have miniature temperature controlled reaction chambers for carrying out a variety of synthetic and diagnostic ...


3

4
Richard A Mathies, Pankaj Singhal, Jin Xie, Alexander N Glazer: Microfabricated capillary electrophoresis chip and method for simultaneously detecting multiple redox labels. The Regents of the University of California, Flehr Hohbach Test Albritton & Herbert, March 26, 2002: US06361671 (171 worldwide citation)

This invention relates to a microfabricated capillary electrophoresis chip for detecting multiple redox-active labels simultaneously using a matrix coding scheme and to a method of selectively labeling analytes for simultaneous electrochemical detection of multiple label-analyte conjugates after ele ...


5
Richard A Mathies, Alexander Glazer, Jingyue Ju: Probes labelled with energy transfer coupled dyes. The Regents of the University of California, Townsend and Townsend and Crew, November 18, 1997: US05688648 (155 worldwide citation)

Compositions are provided comprising sets of fluorescent labels carrying pairs of donor and acceptor dye molecules, designed for efficient excitation of the donors at a single wavelength and emission from the acceptor in each of the pairs at different wavelengths. The different molecules having diff ...


6
Richard A Mathies, Konan Peck, Lubert Stryer: High sensitivity fluorescent single particle and single molecule detection apparatus and method. Board of Trustees of the Leland Stanford Junior University, Flehr Hohbach Test Albritton & Herbert, December 25, 1990: US04979824 (147 worldwide citation)

Apparatus is described for ultrasensitive detection of single fluorescent particles down to the single fluorescent molecule limit in a fluid or on a substrate comprising means for illuminating a predetermined volume of the fluid or area of the substrate whereby to emit light including background lig ...


7
Richard A Mathies, Peter C Simpson, Stephen J Williams: Process for microfabrication of an integrated PCR-CE device and products produced by the same. Affymetrix, Pillsbury Winthrop, July 17, 2001: US06261431 (126 worldwide citation)

A fully integrated monolithic small volume PCR-CE device in glass, or the like materials, is fabricated using thin film metal heaters and thermocouples to thermally cycle sub-microliter PCR volumes. Successful amplification of a PCR fragment is demonstrated on a PCR-CE chip. The process utilizes a l ...


8
Alexander N Glazer, Richard A Mathies, Su Chun Hung, Jingyue Ju: Cyanine dyes with high-absorbance cross section as donor chromophores in energy transfer labels. The Regents of the University of California, Townsend and Townsend and Crew, December 29, 1998: US05853992 (82 worldwide citation)

Cyanine dyes are used as the donor fluorophore in energy transfer labels in which light energy is absorbed by a donor fluorophore and transferred to an acceptor fluorophore which responds to the transfer by emitting fluorescent light for detection. The cyanine dyes impart an unusually high sensitivi ...


9
Richard A Mathies, Alexander Glazer, Jingyue Ju: Fluorescent labels and their use in separations. The Regents of the University of California, Bertram I Rowland, August 5, 1997: US05654419 (79 worldwide citation)

Compositions are provided comprising sets of fluorescent labels carrying pairs of donor and acceptor dye molecules, designed for efficient excitation of the donors at a single wavelength and emission from the acceptor in each of the pairs at different wavelengths. The different molecules having diff ...


10
Richard A Mathies, William H Grover, Alison Skelley, Eric Lagally, Chung N Liu: Fluid control structures in microfluidic devices. The Regents of the University of California, Weaver Austin Villeneuve & Sampson, November 4, 2008: US07445926 (76 worldwide citation)

Methods and apparatus for implementing microfluidic analysis devices are provided. A monolithic elastomer membrane associated with an integrated pneumatic manifold allows the placement and actuation of a variety of fluid control structures, such as structures for pumping, isolating, mixing, routing, ...