1
Higgins Scott, Reuter Dirk, Lough David M, Hillenkamp Franz: Method and apparatus for maldi analysis. Sequenom, January 2, 2003: EP1271609-A2 (6 worldwide citation)

Matrix assisted laser desorption/ionization is performed in a manner to thermalize large analyte ions in a plume of desorbed material for spectroscopic analysis. The thermalized ions have a low or zero mean velocity and are presented at a well-defined instant in time, reducing artifacts and sharpeni ...


2
Hillenkamp Franz, Reuter Dirk, Higgins Scott, Lough David M: Method and apparatus for maldi analysis. Sequenom, October 7, 1998: EP0868740-A1 (5 worldwide citation)

Matrix assisted laser desorption/ionization is performed in a manner to thermalize large analyte ions in a plume of desorbed material for spectroscopic analysis. The thermalized ions have a low or zero mean velocity and are presented at a well-defined instant in time, reducing artifacts and sharpeni ...


3
Lough David M, Köster Hubert, Reuter Dirk, Higgins G Scott: Compositions and methods for immobilizing nucleic acids to solid supports. Sequenom, Lough David M, Köster Hubert, Reuter Dirk, Higgins G Scott, sSEIDMAN Stephanie L, May 14, 1998: WO/1998/020019 (1 worldwide citation)

Compositions containing at least one bead conjugated to a solid support and further conjugated to at least one macromolecule, such as a nucleic acid and methods for making the compositions are provided. The resulting surfaces formed from the beads linked to the solid support advantageously provide i ...


4
Vestergaard Ras Kaas, Willumsen Niels, Oswald Nicholas, Kutchinsky Jonatan, Reuter Dirk, Taboryski Rafael: A substrate providing a cell gigaseal for a patch clamp. Sophion Bioscience, August 25, 2004: GB2398635-A

A substantially planar substrate for use in patch clamp analysis of the electrophysiological properties of a cell 1 membrane comprising a glycocalyx, wherein the substrate comprises an aperture having a rim 4, the rim 4 being adapted to form a gigaseal upon contact with the cell 1 membrane. The inve ...


5
Hillenkamp Franz, Reuter Dirk, Higgins Scott, Lough David M: Procede et dispositif pour analyse en desorption/ionisation laser assistee par matrice (maldi), Method and apparatus for maldi analysis. Sequenom, Sequenom, SMART & BIGGAR, March 26, 1998: CA2237946

Matrix assisted laser desorption/ionization is performed in a manner to thermalize large analyte ions in a plume of desorbed material for spectroscopic analysis. The thermalized ions have a low or zero mean velocity and are presented at a well-defined instant in time, reducing artifacts and sharpeni ...


6
Vestergaard Ras Kaas, Willumsen Niels, Oswald Nicholas, Kutchinsky Jonatan, Reuter Dirk, Taboryski Rafael: Substrat et procede de mesure des proprietes electrophysiologiques de membranes cellulaires, Substrate and method for measuring the electrophysiological properties of cell membranes. Sophion Bioscience, Sophion Bioscience, MCCARTHY TETRAULT, July 7, 2009: CA2480338

The present invention relates to a substantially planar substrate for use in patch clamp analysis of the electrophysiological properties of a cell membrane comprising a glycocalyx, wherein the substrate comprises an aperture having a rim, the rim being adapted to form a gigaseal upon contact with th ...


7
Thomsen Lars, Reuter Dirk, Dodgson John, Wolff Anders, El Ali Jamil: An apparatus and method for determining and/or monitoring electrophysiological properties of ion channels. Sophion Bioscience, March 17, 2004: EP1397677-A1

An apparatus and method for determining and/or monitoring electrophysiological properties of ion channels of ion-channel containing structures uses AC driven location electrodes to drive objects for analysis to a measurement site. The measurement site may comprise an aperture between two solution-co ...


8
Vestergaard Ras Kaas, Willumsen Niels, Oswald Nicholas, Kutchinsky Jonatan, Reuter Dirk, Taboryski Rafael: Substrate and method for measuring the electrophysiological properties of cell membranes. Sophion Bioscience, January 12, 2005: EP1495105-A1

The present invention relates to a substantially planar substrate for use in patch clamp analysis of the electrophysiological properties of a cell membrane comprising a glycocalyx, wherein the substrate comprises an aperture having a rim, the rim being adapted to form a gigaseal upon contact with th ...


9
Köster Hubert, Yip Ping, Steadman Jhobe, Reuter Dirk, Macdonald Richard: Automated analysers. Sequenom, Köster Hubert, Yip Ping, Steadman Jhobe, Reuter Dirk, Macdonald Richard, sSEIDMAN Stephanie L, October 12, 2000: WO/2000/060361

A fully automated modular analytical system integrates instrumentation to permit analysis of biopolymer samples, such as nucleic acids, proteins, peptides and carbohydrates. The system integrates analytical methods of detection and analysis, such as mass spectrometry, radiolabeling, mass tags, chemi ...


10
Vestergaard Ras Kaas, Willumsen Niels, Oswald Nicholas, Kutchinsky Jonatan, Reuter Dirk, Taboryski Rafael: Substrate and method for measuring the electrophysiological properties of cell membranes. Sophion Bioscience, Vestergaard Ras Kaas, Willumsen Niels, Oswald Nicholas, Kutchinsky Jonatan, Reuter Dirk, Taboryski Rafael, JOHNSTONE Helen, October 30, 2003: WO/2003/089564

The present invention relates to a substantially planar substrate for use in patch clamp analysis of the electrophysiological properties of a cell membrane comprising a glycocalyx, wherein the substrate comprises an aperture having a rim, the rim being adapted to form a gigaseal upon contact with th ...