1
Clive R Wood, Daniel T Dransfield, Henk Pieters, Rene Hoet, Simon E Hufton: Method of inhibition of vascular development using an antibody. Dyax, Lahive & Cockfield, Giulio A DeConti, Maria Laccotripe Zacharakis, February 3, 2009: US07485297 (14 worldwide citation)

Tie1 and Tie2 are receptor tyrosine kinase proteins that include a transmembrane domain. Tie1 and Tie2 are present on endothelial cells. This disclosure describes agents, such as antibodies, that bind to Tie1, Tie2, and Ang, including ones that inhibit endothelial cell activity and angiogenesis. The ...


2
Clive R Wood, Daniel T Dransfield, Henk Pieters, Rene Hoet, Simon E Hufton: Antibodies to Tie1 ectodomain. Dyax, McCarter & English, Maria Laccotripe Zacharakis, Marcie B Clarke, January 18, 2011: US07871610 (6 worldwide citation)

Tie1 and Tie2 are receptor tyrosine kinase proteins that include a transmembrane domain. Tie1 and Tie2 are present on endothelial cells. This disclosure describes agents, such as antibodies, that bind to Tie1, Tie2, and Ang, including ones that inhibit endothelial cell activity.


3
Laetitia Devy, Henk Pieters, Robert C Ladner, Rene Hoet, Daniel T Dransfield, Clive R Wood, Maria Henderikx: Antibodies that bind MMP-14. Dyax, Lando & Anastasi, June 29, 2010: US07745587 (6 worldwide citation)

Proteins that bind to matrix metalloproteinase 14 and methods of using such proteins are described.


4
Robert C Ladner, Edward H Cohen, Horacio G Nastri, Kristin L Rookey, Rene Hoet, Hendricus Renerus Jacobus Mattheus Hoogenboom: Methods of constructing libraries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel libraries. Dyax, Lando & Anastasi, Shelby J Walker, Laurie Butler Lawrence, October 16, 2012: US08288322 (4 worldwide citation)

A library containing a collection of genetic packages that display a member of a diverse family of peptides, polypeptides or proteins and that collectively display at least a portion of the family, the displayed peptides, polypeptides or proteins being encoded by DNA sequences containing sequences e ...


5
Laetitia Devy, Sonia Schoonbroodt, Rene Hoet, Nicholas Frans: Metalloproteinase-12 specific monoclonal antibody. Dyax, Lando & Anastasi, February 14, 2012: US08114968 (4 worldwide citation)

Proteins that bind to matrix metalloproteinase 12 and methods of using such proteins are described.


6
Robert C Ladner, Edward H Cohen, Horacio G Nastri, Kristin L Rookey, Rene Hoet, Hendricus Renerus Jacobus Mattheus Hoogenboom: Methods of constructing libraries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel libraries. Dyax, Wolf Greenfield & Sacks P C, December 2, 2014: US08901045 (2 worldwide citation)

Methods useful in constructing libraries that collectively display and/or express members of diverse families of peptides, polypeptides or proteins and the libraries produced using those methods are disclose. Methods of screening those libraries and the peptides, polypeptides or proteins identified ...


7
Sandra Verploegen, David P E Satijn, Rene Hoet, Paul Parren, Jan Van De Winkel, Vibeke Miller Breinholt, Eva Ehrnrooth, Ole Baadsgaard, Tom Vink, Willem Karel Bleeker, Mischa Houtkamp, Maroeska Oudshoorn, Rob N De Jong: Human antibodies against tissue factor and methods of use thereof. GENMAB, Nelson Mullins Riley & Scarborough, Jane E Remillard Esq, Christopher L Frank, October 6, 2015: US09150658 (2 worldwide citation)

Isolated human monoclonal antibodies which bind to human TF and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, and therapeutic and diagnostic methods for using the antibodies.


8
Simon E Hufton, Rene Hoet, Henk Pieters: Tie1-binding ligands. Dyax, Lowrie Lando & Anastasi, March 25, 2008: US07348001 (2 worldwide citation)

Tie1 is a receptor tyrosine kinase protein that includes a transmembrane domain. Tie1 is present on endothelial cells. This disclosure described antibodies that bind to Tie1, including ones that inhibit endothelial cell activity.


9
Joost J Neijssen, Bart De Goeij, Edward Norbert Van Den Brink, Aran Frank Labrijn, Rene Hoet, Janine Schuurman, Paul Parren, Jan Van De Winkel: Monoclonal antibodies against c-Met. GENMAB, Nelson Mullins Riley & Scarborough, Jane E Remillard Esq, Christopher L Frank, June 30, 2015: US09068011 (1 worldwide citation)

Isolated monoclonal antibodies which bind to human c-Met, the hepatocyte growth factor receptor, and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclo ...


10
Robert Charles Ladner, Edward Hirsch Cohen, Horacio Gabriel Nastri, Kristin L Rookey, Rene Hoet, Hendricus Renerus Jacobus Mattheus Hoogenboom: Methods of constructing libraries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel libraries. Dyax, Wolf Greenfield & Sacks P C, June 20, 2017: US09683028

Methods useful in constructing libraries that collectively display and/or express members of diverse families of peptides, polypeptides or proteins and the libraries produced using those methods. Methods of screening those libraries and the peptides, polypeptides or proteins identified by such scree ...