1
Walter Durckheimer, Dieter Bormann, Eberhard Ehlers, Elmar Schrinner, Rene Heymes: Cephem derivative. Hoechst Aktiengesellschaft, Curtis Morris & Safford, July 14, 1981: US04278793 (147 worldwide citation)

Cephem derivatives of the general formula ##STR1## in which the R.sub.2 O group is in the syn-position, a process for their manufacture and pharmaceutical formulations which are active against bacterial infections and contain these compounds.


2
Rene Heymes, Andre Lutz: 3-Acetoxymethyl-7-(iminoacetamido)-cephalosporanic acid derivatives. Roussel Uclaf, Hammond & Littell, May 1, 1979: US04152432 (72 worldwide citation)

Compounds of the formula ##STR1## wherein R is selected from the group consisting of hydrogen and groups easily removable by acid hydrolysis or hydrogenolysis, R' is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms, alkenyl and alkynyl of 2 to 4 carbon atoms and groups ea ...


3
Rene Heymes, Andre Lutz: Alkyloximes of 7-amino-thiazolyl-acetamido-cephalosporanic acids. Roussel Uclaf, Hammond & Littell Weissenberger and Muserlian, May 13, 1980: US04202893 (21 worldwide citation)

Novel alkyloximes of 7-amino-thiazolyl-acetamidocephalosporanic acids of the formula ##STR1## wherein R is selected from the group consisting of alkyl of 1 to 5 carbon atoms, cycloalkyl of 3 to 5 carbon atoms and --CH.sub.2 --SR', R' is selected from the group consisting of acyl of an alkanoic acid ...


4
Rene Heymes, Didier Pronine: Cephalosporins. RousselUclaf, Bierman and Muserlian, February 12, 1991: US04992431 (20 worldwide citation)

Novel syn isomers of 3-alkoxymethyl or 3-alkylthiomethyl-7-[2-(2-amino-4-thiazolyl)-2-oximino-acetamido]-cephalos poranic acid compounds of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl and alkynyl of 2 to 6 carbon atoms, cycl ...


5
Rene Heymes, Andre Lutz: 3-Acetoxymethyl-7-(hydroxyiminoacetamido)-cephalosporanic acid derivatives. Roussel Uclaf, Hammond & Littell Weissenberger and Muserlian, August 11, 1981: US04283396 (15 worldwide citation)

Compounds of the formula ##STR1## wherein R is selected from the group consisting of hydrogen and groups easily removable by acid hydrolysis or hydrogenolysis, R' is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms, alkenyl and alkynyl of 2 to 4 carbon atoms and groups ea ...


6
Walter Durckheimer, Dieter Bormann, Eberhard Ehlers, Elmar Schrinner, Rene Heymes: Cephem derivatives. Hoechst Aktiengesellschaft, Curtis Morris & Safford, July 19, 1988: US04758556 (14 worldwide citation)

Cephem derivatives of the general formula ##STR1## in which the R.sub.2 O group is in the syn-position, a process for their manufacture and pharmaceutical formulations which are active against bacterial infections and contain these compounds.


7
Rene Heymes: Cephalosporanic acid derivatives. Roussel Uclaf, Hammond & Littell Weissenberger and Muserlian, September 8, 1981: US04288434 (10 worldwide citation)

Novel syn isomers of 7-amino-thiazolyl-acetamido-3-acetoxymethyl-cephalosporanic acid derivatives of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of --CN, --CONH.sub.2 and --COOR.sub.1 ', R.sub.1 ' is selected from the group consisting of alkyl of 1 to 3 carbon atoms, h ...


8
Rene Heymes, Jean Jolly, Primo Rizzi: Process for the preparation of derivative of 7-[(2-hydroxyimino)-acetamido]-cephalosporanic acid. Roussel Uclaf, Bierman and Muserlian, October 27, 1992: US05159070 (9 worldwide citation)

A novel process for the preparation of syn isomers of cephalosporanic acid derivatives of the formula ##STR1## comprising reacting first in a solvent and optionally in the presence of a base, a compound of the formula ##STR2## with a compound of the formula


9
Rene Heymes: 7-Amino-thiazolyl acetamido cephalosporanic acids. Roussel Uclaf, Hammond & Littell, June 27, 1978: US04097595 (8 worldwide citation)

Novel 7-amino-thiazolyl-acetamido-cephalosporanic acid compounds of the formula ##STR1## wherein R is selected from the group consisting of hydrogen and a group easily removable by acid hydrolysis or hydrogenolysis, R.sub.1 is selected from the group consisting of alkyl of 1 to 4 carbon atoms, a 5 m ...


10
Rene Heymes, Michel Vignau: Oximes. Roussel Uclaf, Bierman Bierman Peroff & Muserlian, March 27, 1984: US04439433 (8 worldwide citation)

Novel oximes of the syn isomers of 7-[2-(2-amino-4-thiazolyl)-acetamido]ceph-3-eme-4-carboxylic acid compounds of the fomrula ##STR1## wherein B is --(CH.sub.2).sub.n' --R.sub.5, n' is an integer from 1 to 4, R.sub.5 is ##STR2## R.sub.6 and R.sub.7 are individually selected from the group consisting ...



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