1
Reiner Class, Michael Zeppezauer: Antimicrobial histone H1 compositions, kits, and methods of use thereof. Symbiotec, Philadelphia Health and Education Corporation, Akin Gump Strauss Hauer & Feld, April 26, 2005: US06884423 (3 worldwide citation)

The invention includes antibiotic pharmaceutical compositions comprising eukaryotic histone H1 protein and methods of using eukaryotic histone H1 protein to kill or to inhibit the growth of microorganisms, including, but not limited to, human pathogenic bacteria. The invention further includes a euk ...


2
Michael Zeppezauer, Reiner Class: Therapeutic method for treatment of carcinoma or autoimmune diseases. Allegheny University of the Health Sciences, Kanesaka & Takeuchi, July 14, 1998: US05780432 (3 worldwide citation)

A therapeutic method for treatment of carcinoma or autoimmune diseases of a patient, which includes administering to said patient a biologically active composition which comprises a therapeutically acceptable carrier and, in a quantity having a therapeutic effect, two active substances comprising a ...


3
Michael Zeppezauer, Hans Peter Leinenbach, Reiner Class, Cordula Fassbender: Therapeutic, prophylactic, and diagnostic agent for cancer, useful for characterizing cancer cells with individual properties. Bacon & Thomas PLLC, March 8, 2011: US07902146 (2 worldwide citation)

A therapeutic or prophylactic agent for cancer is disclosed which damages the membrane and kills cancer cells, in particular of the blood-forming system, having membrane protein aggregates which contain several core histones or largely core-like histones and/or their parts. The therapeutic or prophy ...


4
Reiner Class, Michael Zeppezauer: Use of histones for therapeutic purposes. Lipoxen Technologies Incorporated, One3 IP Management P C, Mary M H Eliason, Dean Stathakis, February 24, 2015: US08962562

The invention relates to the use of at least one human recombinant histone, especially at least one histone H1 subtype, and/or a therapeutic histone fraction as a basis for the treatment of thrombocytopenia.


5
Reiner Class: Methods of treating virally-infected living cells with histones. Symbiotic Genellschaft zur Erforschung auf dem Geibeit der Biotechnologie MBH, One3 IP Management P C, Annette S Parent, Dean G Stathakis, August 16, 2016: US09415089

There is provided a biologically-active agent, in particular, for the early diagnosis and/or preventative therapy of virally-infected living cells, the efficacy of which is selective for the cell membranes of the virally-infected cells, which are modified after viral infection. The agent includes at ...


6
Zeppezauer Michael, Reiner Class: Use of histones for therapeutic purposes. Symbiotec, January 23, 2008: EP1879609-A2

The invention relates to the use of at least one human recombinant histone, especially at least one histone H1 subtype, and/or a therapeutic histone fraction as a basis for the treatment of thrombocytopenia.


7
Reiner Class, Gerald Sosiau, Michael Zeppeznuer: Compositions and methods for preventing platelet aggregation. Licatla & Tyrrell PC, November 4, 2004: US20040219140-A1

Compositions and methods for preventing platelet aggregation and treating cardiovascular disease via histone compounds are provided.


8
Reiner Class: Use of histones for the early diagnosis and/or preventive therapy of virally-infected living cells and a biochip for carrying out said diagnosis. Takeuchi & Kubotera, May 17, 2007: US20070110768-A1

The invention relates to a biologically-active agent, in particular, for the early diagnosis and/or preventative therapy of virally-infected living cells, the efficacy of which is selective for the cell membranes of the virally-infected cells, which are modified in a characteristic manner after vira ...


9
Michael Zeppezauer, Hans Peter Leinenbach, Reiner Class, Cordula Fassbender: Therapeutic, prophylactic, and diagnostic agent for cancer, useful for characterizing cancer cells with individual properties. Bacon & Thomas Pllc, August 30, 2007: US20070203067-A1

A therapeutic or prophylactic agent for cancer is disclosed which damages the membrane and kills cancer cells, in particular of the blood-forming system, having membrane protein aggregates which contain several core histones or largely core-like histones and/or their parts. The therapeutic or prophy ...


10
Michael Zeppezauer, Hans Peter Leinenbach, Reiner Class, Cordula Fassbender: Therapeutic, prophylactic, and diagnostic agent for cancer, useful for characterizing cancer cells with individual properties. Bacon & Thomas Pllc, January 23, 2003: US20030017987-A1

A therapeutic or prophylactic agent for cancer is disclosed which damages the membrane and kills cancer cells, in particular of the blood-forming system, having membrane protein aggregates which contain several core histones or largely core-like histones and/or their parts. The therapeutic or prophy ...



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