41
Michael S Roberts, Robert M Lorence, William S Groene, Harvey Rabin, Reid W von Borstel: Treatment of neoplasms with RNA viruses. Wellstat Biologics Corporation, Douglas A Golightly, August 24, 2010: US07780962 (2 worldwide citation)

The subject invention relates to viruses that are able to replicate and thereby kill neoplastic cells with a deficiency in the IFN-mediated antiviral response, and their use in treating neoplastic disease including cancer and large tumors. RNA and DNA viruses are useful in this regard. The invention ...


42
Shalini Sharma, Reid W von Borstel: Compounds for the treatment of metabolic disorders. Wellstat Therapeutics Corporation, Lewis J Kreisler, March 29, 2011: US07915429 (2 worldwide citation)

Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, polycystic ovary syndrome, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis are disclosed, wherein n is 1 or 2; m is 0, 1, 2, 3 or 4; q is 0 or 1 ...


43
Reid W von Borstel, Michael K Bamat, Bradley M Hiltbrand: Pyrimidine nucleotide precursors for treatment of systemic inflammation and inflammatory hepatitis. Wellstat Therapeutics Corporation, Lewis J Kreisler, May 4, 2010: US07709459 (2 worldwide citation)

Pyrimidine nucleotide precursors including acyl derivatives of cytidine, uridine, and orotate, and uridine phosphorylase inhibitors, and their use in enhancing resistance to sepsis or systemic inflammation are disclosed.


44
Reid W Von Borstel, Michael K Bamat: Acyl deoxyribonucleoside derivatives and uses thereof. Wellstat Therapeutics Corporation, Nixon & Vanderhye, June 1, 2004: US06743782 (2 worldwide citation)

The invention relates to compositions comprising acyl derivates of 2′-deoxyribonucleosides. The invention also relates to methods of treating or preventing radiation, mutagen and sunligth-induced cellular damage, methods for improving wound healing and tissue repair, and methods for ameliorating the ...


45
Kirvin L Hodge, Shalini Sharma, Reid W von Borstel, Stephen D Wolpe: Compounds for the treatment of metabolic disorders. Wellstat Therapeutics Corporation, Lewis J Kreisler, July 5, 2011: US07973052 (1 worldwide citation)

Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis are disclosed. wherein n is 1 or 2; m is 0, 1, 2, 3 or 4; q is 0 or 1; t is 0 or 1; R2 is alkyl ...


46
Kirvin L Hodge, Shalini Sharma, Reid W von Borstel: Compositions for the treatment of metabolic disorders. Wellstat Therapeutics Corporation, Lewis J Kreisler, July 6, 2010: US07749990 (1 worldwide citation)

Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis are disclosed. wherein n is 1 or 2; m is 0 to 4; q is 0 or 1; t is 0 or 1; R2 is alkyl having fr ...


47
Shalini Sharma, Reid W von Borstel: Compounds for the treatment of metabolic disorders. Wellstat Therapeutics Corporation, Lewis J Kreisler, September 20, 2011: US08022249 (1 worldwide citation)

Compounds useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis are disclosed. wherein n is 1 or 2; m is 0, 1, 2, 3, 4 or 5; q is 0 or 1; t is 0 or 1; R1 is ...


48
James Dennen O Neil, Michael K Bamat, Reid W von Borstel, Shalini Sharma, Ramachandran Arudchandran: Compounds and method for reducing uric acid. Wellstat Therapeutics Corporation, Lewis J Kreisler, September 9, 2014: US08829058 (1 worldwide citation)

Uric acid in mammalian subjects is reduced and excretion of uric acid is increased by administering a compound of Formula I or a pharmaceutically acceptable salt thereof. In Formula I m is 0, 1, 2, 3 or 4; n is 0 or 1; t is 0 or 1; q is 0 or 1; and r is 0, 1 or 2. R6 is hydrogen, O or hydroxyl. R7 i ...


49
Shalini Sharma, Reid W von Borstel: Compounds for the treatment of metabolic disorders. Wellstat Therapeutics Corporation, Lewis J Kreisler, May 3, 2011: US07935689 (1 worldwide citation)

Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, polycystic ovary syndrome, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis are disclosed, compound of the formula (I): wherein n is 1 or 2; m is ...


50
Shalini Sharma, Reid W von Borstel: Compounds for the treatment of metabolic disorders. Wellstat Therapeutics Corporation, Lewis J Kreisler, May 24, 2011: US07947735 (1 worldwide citation)

Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, polycystic ovary syndrome, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis are disclosed. Formula (I), wherein n is 1 or 2; m is 0, 1, 2, 3, or ...