31
Reid W von Borstel, Michael K Bamat, Bradley M Hiltbrand, James C Butler, Shyam Shirali: Oxypurine nucleosides and their congeners, and acyl derivatives thereof, for improvement of hematopoiesis. Pro Neuron, Nixon & Vanderhye, April 25, 2000: US06054441 (4 worldwide citation)

The invention relates to certain oxypurine nucleosides, congeners of such oxypurine nucleosides, and acyl derivatives thereof, and compositions which contain at least one of these compounds. The invention also relates to methods of treating or preventing hematopoietic disorders and modifying hematop ...


32
Reid W von Borstel, Fedor Romantsev: Antimutagenic compositions for treatment and prevention of photodamage to skin. Pro Neuron, Nixon & Vanderhye, July 3, 2001: US06255290 (4 worldwide citation)

A method of improving DNA repair and reducing DNA damage and for reducing mutation frequency in skin for the purpose of reducing consequences of exposure to solar or ultraviolet radiation is disclosed. The methods comprise administering to the skin a composition containing deoxyribonucleosides in co ...


33
Reid W von Borstel, Fedor Romantsev: Antimutagenic compositions for treatment and prevention of photodamage to skin. Pro Neuron, Nixon & Vanderhye, June 11, 2002: US06403565 (4 worldwide citation)

A method of improving DNA repair and reducing DNA damage and for reducing mutation frequency in skin for the purpose of reducing consequences of exposure to solar or ultraviolet radiation is disclosed. The methods comprise administering to the skin a composition containing deoxyribonucleosides in co ...


34
Kirvin L Hodge, Shalini Sharma, Albert C Lee, Reid W von Borstel: Method for the treatment of metabolic disorders. Wellstat Biologics Corporation, Lewis J Kreisler, April 26, 2011: US07932290 (3 worldwide citation)

Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis are disclosed. wherein n is 1 or 2; m is 0, 1, 2, 4, or 5; q is 0 or 1; t is 0 or 1; R2 is alkyl ...


35
Michael S Roberts, Robert M Lorence, William S Groene, Harvey Rabin, Reid W von Borstel: Treatment of neoplasms with viruses. Wellstat Biologics Corporation, Nixon & Vanderhye, December 30, 2008: US07470426 (3 worldwide citation)

The subject invention relates to viruses that are able to replicate and thereby kill neoplastic cells with a deficiency in the IFN-mediated antiviral response, and their use in treating neoplastic disease including cancer and large tumors. RNA and DNA viruses are useful in this regard. The invention ...


36
Reid W von Borstel, Michael K Bamat, Bradley M Hiltbrand, James C Butler, Shyam Shirali: Oxpurine nucleosides and their congeners, and acyl, derivatives thereof, for improvement of hematopoiesis. Wellstat Therapeutics Corporation, Nixon & Vanderhye, December 11, 2007: US07307166 (3 worldwide citation)

The invention relates to certain oxypurine nucleosides, congeners of such oxypurine nucleosides, and acyl derivatives thereof, and compositions which contain at least one of these compounds. The invention also relates to methods of treating or preventing hematopoietic disorders and modifying hematop ...


37
Kirvin L Hodge, Shalini Sharma, Reid W von Borstel, Stephen D Wolpe: Treatment of metabolic disorders. Wellstat Therapeutics Corporation, Lewis J Kreisler, January 12, 2010: US07645772 (3 worldwide citation)

Compounds useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis, are disclosed.


38
Reid W von Borstel, Michael K Bamat: Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides. Wellstat Therapeutics Corporation, Nixon & Vanderhye, January 23, 2007: US07166581 (3 worldwide citation)

The subject invention discloses compounds, compositions and methods for treatment and prevention of toxicity due to chemotherapeutic agents and antiviral agents. Disclosed are acylated derivatives of non-methylated pyrimidine nucleosides. These compounds are capable of attenuating damage to the hema ...


39
Reid W von Borstel, Michael K Bamat, Bradley M Hiltbrand: Pyrimidine nucleotide precursors for treatment of systemic inflammation and inflammatory hepatitis. Pro Neuron, Nixon & Vanderhye, December 11, 2001: US06329350 (3 worldwide citation)

Pyrimidine nucleotide precursors including acyl derivatives of cytidine, uridine, and orotate, and uridine phosphorylase inhibitors, and their use in enhancing resistance to sepsis or systemic inflammation are disclosed.


40
Michael S Roberts, Robert M Lorence, William S Groene, Harvey Rabin, Reid W von Borstel: Infection and treatment of neoplasms with vesicular stomatitis virus. Wellstat Biologics Corporation, Douglas A Golightly, October 25, 2011: US08043612 (2 worldwide citation)

The subject invention relates to viruses that are able to replicate and thereby kill neoplastic cells with a deficiency in the IFN-mediated antiviral response, and their use in treating neoplastic disease including cancer and large tumors. RNA and DNA viruses are useful in this regard. The invention ...