1
Pulla Reddy Muddasani, Venkaiah Chowdary Nannapaneni: Process for the preparation of sorafenib. Natco Pharma, Pulla Reddy Muddasani, Venkaiah Chowdary Nannapaneni, April 30, 2009: WO/2009/054004 (10 worldwide citation)

A novel and improved process for the preparation of sorafenib (4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide) of formula I involving a novel intermediate of formula II as key intermediate is disclosed. Sorafenib tosylate, available in the market as Nexavar is a mul ...


2
Pulla, Reddy Muddasani, Usha, Rani Vattikuti, Venkaiah, Chowdary Nannapaneni: An improved process for the preparation of zoledronic acid. Natco Pharma, Pulla, Reddy Muddasani, Usha, Rani Vattikuti, Venkaiah, Chowdary Nannapaneni, July 14, 2005: WO/2005/063717 (8 worldwide citation)

The invention disclosed in this application relates to an improved process for the preparation of zoledronic acid of formula (I) given below which comprises heating at a temperature in the range of 50-80 °C a solution of imidazol-1-ylacetic acid hydrochloride with ortho-phosphoric acid in a solvent ...


3
Pulla, Reddy Muddasani, Venkaiah, Chowdary Nannapaneni: Improved process for the preparation of high purity anastrozole. Natco Pharma, Pulla, Reddy Muddasani, Venkaiah, Chowdary Nannapaneni, November 10, 2005: WO/2005/105762 (5 worldwide citation)

Present invention discloses an improved process for the preparation of high purity anastrozole of formula-I (2,2'-[5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-phenylene]di(2-methylpropio-nitrile) consisting of: (i) halogenation of 5, &agr;, &agr;, &agr;', &agr;'-pentamethyl-1,3-benzenediacetonitrile; (ii) r ...


4
Ravi Janaki Rama Rao, Pulla, Reddy Muddasani, Adibatla Kali, Satya Bhujanga Rao, Benkaiah, Chowdary Nannapaneni: Polymorphic forms of bortezomib and process for their preparation. Natco Pharma, Ravi Janaki Rama Rao, Pulla, Reddy Muddasani, Adibatla Kali, Satya Bhujanga Rao, Benkaiah, Chowdary Nannapaneni, June 26, 2008: WO/2008/075376 (4 worldwide citation)

The present invention relates to two novel and stable polymorphic forms, namely Form I and Form II of bortezomib (1) and processes for the preparation of these forms. Bortezomib is an anti-neoplastic agent used in the treatment of multiple myeloma.


5
Pulla, Reddy Muddasani, Ajit, Yashwant Junnarkar, Rajasekhara Reddy Peddi, Adibatla Kali, Satya Bhujanga Rao, Madireddi Umamaheshwar Rao Naidu, Venkaiah, Chowdary Nannapaneni: 3-aryloxy 3-substituted propanamines. Natco Pharma, Pulla, Reddy Muddasani, Ajit, Yashwant Junnarkar, Rajasekhara Reddy Peddi, Adibatla Kali, Satya Bhujanga Rao, Madireddi Umamaheshwar Rao Naidu, Venkaiah, Chowdary Nannapaneni, July 10, 2008: WO/2008/081477 (4 worldwide citation)

Present invention relates to novel 3-aryloxy 3-substituted propanamines of formula (I), method of preparing the same and to their use in inhibiting serotonin and norepinephrine reuptake wherein A is a phenyl which is optionally substituted with up to five substituents; a 1- or 2-naphthyl which is un ...


6
Jyothi, Prasad Ramanadham, Pulla, Reddy Muddasani, Nageshwara, Rao Bollepalli, Venkaiah, Chowdary Nannapaneni: An improved process for the preparation of gefitinib. Natco Pharma, Jyothi, Prasad Ramanadham, Pulla, Reddy Muddasani, Nageshwara, Rao Bollepalli, Venkaiah, Chowdary Nannapaneni, August 4, 2005: WO/2005/070909 (4 worldwide citation)

Present invention discloses an improved process for the preparation of gefitinib (4-(3'-chloro-4'-fluorophenylamino)-7-methoxy-6-[3-(4-morpholinyl)propoxy]quinazoline), of formula-I, which comprises: (i) etherification of iso-vanillin with 3-morpholinopropyl halide, (ii) nitration using nitric acid, ...


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Venkaiah, Chowdary Nannapaneni, Pulla, Reddy Muddasani: A process for the preparation of 3-and 4-aminophthalimide.. Natco Pharma, Venkaiah, Chowdary Nannapaneni, Pulla, Reddy Muddasani, May 27, 2004: WO/2004/043919 (2 worldwide citation)

The invention discloses a simple, economical, and effluents-free process for the preparation of 3- and 4-aminophthalimides of formula (I) by reduction of the corresponding nitrophthalimides of formula (II) under heterogeneous hydrogenation conditions using Pd, Pt, Ni catalysts at different temperatu ...


9
Pulla Reddy Muddasani, Veerababu Madalapu, Venkaiah Chowdary Nannapaneni: Process for the preparation of lacosamide. Natco Pharma, Kilpatrick Townsend & Stockton, June 24, 2014: US08759582 (1 worldwide citation)

Present invention relates to an improved and commercial process for the preparation of lacosamide ((R)-2-acetamido-N-benzyl-3-methoxypropanamide) of formula (I). Present process utilizes high purity crystalline solids of formulae (XXXII) and (XIII) as key intermediates. Lacosamide is indicated for t ...


10
Natarajan Kadathur S, Arumugam Karthikeyan, Reddy Muddasani S, Valdivia Mary M, Singh Ajoy K: Apparatus and method for mobile/ip handoff between a plurality of access technologies. Motorola, PACE Lalita W, June 3, 2004: WO/2004/046853 (1 worldwide citation)

An apparatus and method for performing Mobile/IP handoff between different access technologies. Associated with each access technology are two thresholds, a Low Water Mark and a High Water Mark. The method uses these water marks to its access technology selection in a particular environment. Using t ...