1
Raymond F Schinazi, Dennis C Liotta, Chung K Chu, J Jeffrey McAtee, Junxing Shi, Yongseok Choi, Kyeong Lee, Joon H Hong: 2′-Fluoronucleosides. Emory University, University of Georgia Research Foundation, Sherry M Knowles Esq, Josephine Young, King & Spalding, February 19, 2002: US06348587 (115 worldwide citation)

A class of 2′-fluoro-nucleoside compounds are disclosed which are useful in the treatment of hepatitis B infection, hepatitis C infection, HIV and abnormal cellular proliferation, including tumors and cancer. The compounds have the general formulae:


2
Dennis C Liotta, Raymond F Schinazi, Woo Baeg Choi: Method for the synthesis, compositions and use of 2-deoxy-5-fluoro-3-thiacytidine and related compounds. Emory University, Kilpatrick & Cody, May 11, 1993: US05210085 (83 worldwide citation)

The present invention relates to a method of preparing the antiviral compounds 2'-deoxy-5-fluoro-3'thiacytidine (FTC) and various prodrug analogues of FTC from inexpensive precursors with the option of introducing functionality as needed; methods of using these compounds, particularly in the prevent ...


3
Raymond F Schinazi, Dennis C Liotta, Chung K Chu, J Jeffrey McAtee, Junxing Shi, Yongseok Choi, Kyeong Lee, Joon H Hong: 2′-fluoronucleosides. Emory University, Sherry M Knowles Esq, King & Spalding, June 28, 2005: US06911424 (72 worldwide citation)

A class of 2′-fluoro-nucleoside compounds are disclosed which are useful in the treatment of hepatitis B infection, hepatitis C infection, HIV and abnormal cellular proliferation, including tumors and cancer. The compounds have the general formulae: wherein Base is a purine or pyrimidine base; R1 is ...


4
Chung K Chu, Raymond F Schinazi: 3-Azido-2,3-dideoxyuridine anti-retroviral composition. University of Georgia Research Foundation, Emory University, Kilpatrick & Cody, April 10, 1990: US04916122 (65 worldwide citation)

Compositions for the treatment of AIDS and ARC having the following compound as an active ingredient: ##STR1## where R.sup.1 is OH, monophosphate, diphosphate, or triphosphate; or a pharmacologically acceptable salt thereof.


5
Raymond F Schinazi, Dennis C Liotta: Compositions containing 5-fluoro-2,3-didehydro-2,3-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent. Emory University, Kilpatrick Stockton, December 30, 1997: US05703058 (59 worldwide citation)

A method and composition for the treatment of HIV and HBV infections in humans and other host animals is disclosed that includes the administration of an effective amount of a �5-carboxamido or 5-fluoro!-2',3'-dideoxy-2',3'-didehydro-pyrimidine nucleoside or a �5-carboxamido or 5-fluoro!-3'-modified ...


6
Raymond F Schinazi, Dennis C Liotta: �5--Caboxamido or 5--fluoro!--�2, 3--unsaturated or 3--modified!--pyrimidine nucleosides. Emory University, Sherry M Knowles, Jacqueline King & Spalding Haley, May 18, 1999: US05905070 (53 worldwide citation)

A method and composition for the treatment of HIV and HBV infections in humans and other host animals is disclosed that includes the administration of an effective amount of a �5-carboxamido or 5-fluoro!-2',3'-dideoxy-2',3'-didehydro-pyrimidine nucleoside or a �5-carboxamido or 5-fluoro!-3'-modified ...


7
Dennis C Liotta, Raymond F Schinazi, Woo Baeg Choi: Method for the synthesis, compositions and use of 2-deoxy-5-fluoro-3-thiacytidine and related compounds. Emory University, Sherry M Knowles, Jacqueline King & Spalding Haley, September 29, 1998: US05814639 (52 worldwide citation)

The present invention relates to a method of preparing the antiviral compounds 2'-deoxy-5-fluoro-3'thiacytidine (FTC) and various prodrug analogues of FTC from inexpensive precursors with the option of introducing functionality as needed; methods of using these compounds, particularly in the prevent ...


8
Raymond F Schinazi, Jean Pierre Sommadossi, Chung K Chu, William M Shafer: 5-diphosphohexose nucleoside pharmaceutical compositions. University of Georgia Research Foundation, Emory University, UAB Research Foundation, Kilpatrick & Cody, June 2, 1992: US05118672 (51 worldwide citation)

This invention provides compounds and pharmaceutical compositions that include compounds of the formula: ##STR1## in which A, B, and C are hydrogen, halogen, or azido; D is hydrogen, halogen, azido, or OH; A and B or C and D can be replaced with a double bond; R is an aldohexose, aldohexosamine, or ...


9
Raymond F Schinazi, Dennis C Liotta, Chung K Chu, J Jeffrey McAtee, Junxing Shi, Yongseok Choi, Kyeong Lee, Joon H Hong: 2′-Fluoronucleosides. Emory University, The University of Georgia Research Foundation, King & Spalding, December 11, 2007: US07307065 (50 worldwide citation)

A class of 2′-fluoro-nucleoside compounds are disclosed which are useful in the treatment of hepatitis B infection, hepatitis C infection, HIV and abnormal cellular proliferation, including tumors and cancer. The compounds have the general formulae: wherein Base is a purine or pyrimidine base; R1 is ...


10
Raymond F Schinazi, Dennis C Liotta: Treatment of HIV by administration of &bgr;-D-2′, 3′-didehydro-2′,3′-dideoxy-5-fluorocytidine (D4FC). Emory University, Sherry M Knowles Esq, King & Spalding, May 15, 2001: US06232300 (49 worldwide citation)

A method and composition for the treatment of HIV and HBV infections in humans and other host animals is disclosed that includes the administration of an effective amount of a [5-carboxamido or 5-fluoro]-2′,3′-dideoxy-2′,3′-didehydro-pyrimidine nucleoside or a [5-carboxamido or 5-fluo ...