1
Coates William John, Flynn Seyn Thomas, Rawlings Derek Anthony: Fused pyrimidine derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them.. Smith Kline French Lab, December 20, 1989: EP0347146-A2 (101 worldwide citation)

Compounds of the formula (1) : or pharmaceutically acceptable salts thereof as described, wherein is a pyridine, pyrazine or triazine ring; R is C1-6alkyl, C2-6alkenyl, C3-5cycloalkylC1-6alkyl, or C1-6alkyl substituted by 1 to 6 fluoro groups; R is C1-6alkylthio, C1-6alkylsulphonyl, C1-6alkoxy, hydr ...


2
Coates William John, Rawlings Derek Anthony: Condensed pyrimidine derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them.. Smith Kline French Lab, January 3, 1990: EP0349239-A2 (85 worldwide citation)

Compounds of the formula (1) : and pharmaceutically acceptable salts are described wherein is a ring of sub-formula (a), (b) or (c): X is oxygen or sulphur, and R is C1-6alkyl, C2-6alkenyl, C3-5cycloalkylC1-4alkyl, or C1-4alkyl substituted by 1 to 6 fluoro groups. Their use as medicaments, pharmaceu ...


3
Coates William John, Rawlings Derek Anthony: Chemical compounds.. Smith Kline French Lab, October 31, 1990: EP0395328-A2 (54 worldwide citation)

Compounds of the formula (1) : and pharmaceutically acceptable salts thereof are described wherein R is C1-6alkyl, C2-6alkenyl, C3-5cycloalkylC1-6alkyl, phenylC1-6alkyl or C1-6alkyl substituted by 1 to 6 fluoro groups; and R is C1-6alkyl, phenyl, hydroxy, C1-6alkoxy, halo, -NHCOR, -NHCONHR, 5-tetraz ...


4

5
Eatherton Andrew John, Giblin Gerard Martin Paul, Green Richard Howard, Mitchell William Leonard, Naylor Alan, Rawlings Derek Anthony, Slingsby Brian Peter, Whittington Andrew Richard: Pyrimidine derivatives and their use as cb2 modulators. Glaxo Group, Eatherton Andrew John, Giblin Gerard Martin Paul, Green Richard Howard, Mitchell William Leonard, Naylor Alan, Rawlings Derek Anthony, Slingsby Brian Peter, Whittington Andrew Richard, sHOCKLEY Sian Catherine, March 4, 2004: WO/2004/018433 (18 worldwide citation)

This relates to novel pyrimidine derivatives, pharmaceutical compositions containing these compounds and their use in the treatment of diseases, particularly pain, which diseases are caused directly or indirectly by an increase or decrease in activity of the cannabinoid receptor.


6
Eatherton Andrew John, Giblin Gerard Martin Paul, Green Richard Howard, Jandu Karamjit Singh, Mitchell William Leonard, Naylor Alan, Palombi Giovanni, Rawlings Derek Anthony, Slingsby Brian Peter, Whittington Andrew Richard: Pyridine derivatives as cb2 receptor modulators. Glaxo Group, Eatherton Andrew John, Giblin Gerard Martin Paul, Jandu Karamjit Singh, Mitchell William Leonard, Naylor Alan, Palombi Giovanni, Rawlings Derek Anthony, Slingsby Brian Peter, Whittington Andrew Richard, sHOCKLEY Sian Catherine, April 8, 2004: WO/2004/029027 (16 worldwide citation)

The present invention relates to novel pyridine derivatives of formula (I) pharmaceutical compositions containing these compounds and their use in the treatment of diseases, particularly pain, which diseases are caused directly or indirectly by an increase or decrease in activity of the cannabinoid ...


7
Eatherton Andrew John, Giblin Gerard Martin Paul, Green Richard Howard, Jandu Karamjit Singh, Mitchell William Leonard, Naylor Alan, Palombi Giovanni, Rawlings Derek Anthony, Slingsby Brian Peter, Whittington Andrew Richard: Pyridine derivatives as cb2 receptor modulators. Glaxo Group, Eatherton Andrew John, Giblin Gerard Martin Paul, Jandu Karamjit Singh, Mitchell William Leonard, Naylor Alan, Palombi Giovanni, Rawlings Derek Anthony, Slingsby Brian Peter, Whittington Andrew Richard, HOCKLEY Sian Catherine, April 8, 2004: WO/2004/029026 (8 worldwide citation)

The present invention relates to novel pyridine derivatives, pharmaceutical compositions containing these compounds and their use in the treatment of diseases, particularly pain, which diseases are caused directly or indirectly by an increase or decrease in activity of the cannabinoid receptor.


8
Gibson Mairi, Hall Adrian, Hurst David Nigel, Rawlings Derek Anthony: Benzofuran compounds as ep1 receptor antagonists. Glaxo Group, Gibson Mairi, Hall Adrian, Hurst David Nigel, Rawlings Derek Anthony, STEVENSON Dian Elizabeth, October 11, 2007: WO/2007/113289 (8 worldwide citation)

Compounds of formula (I) or a pharmaceutically acceptable derivative thereof, wherein R1,R2a, R2b, R2c, and R3 are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions comprising such compounds and the use of such compounds in medicine.


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Eatherton Andrew John, Giblin Gerard Martin Paul, Green Richard Howard, Mitchell William Leonard, Naylor Alan, Rawlings Derek Anthony, Slingsby Brian Peter, Whittington Andrew Richard: Pyrimidine compounds. Glaxo Group, Eatherton Andrew John, Giblin Gerard Martin Paul, Mitchell William Leonard, Naylor Alan, Rawlings Derek Anthony, Slingsby Brian Peter, Whittington Andrew Richard, Doughty Jennifer Margaret, sHOCKLEY Sian Catherine, March 4, 2004: WO/2004/018434 (3 worldwide citation)

The present invention relates to novel pyrimidine derivatives, pharmaceutical compositions containing these compounds and their use in the treatment of diseases, particularly pain, which diseases are caused directly or indirectly by an increase or decrease in activity of the cannabinoid receptor.