1
Randy R Robinson, Alvin Y Liu, Jeffrey A Ledbetter: Chimeric antibody with specificity to human B cell surface antigen. XOMA Corporation, Sterne Kessler Goldstein & Fox, March 19, 1996: US05500362 (339 worldwide citation)

The present invention relates to a chimeric IgG1 antibody molecule comprising two heavy chains and two light chains, each of the chains comprising a human constant region and a variable region, said antibody having specificity for the antigen bound by the 2H7 murine monoclonal antibody. The inventio ...


2
Randy R Robinson, Alvin Y Liu, Arnold H Horwitz, Marc Better, Randolph Wall, Shau Ping Lei, Gary L Wilcox: Modular assembly of antibody genes, antibodies prepared thereby and use. Xoma Corporation, Sterne Kessler Goldstein & Fox p l l c, April 8, 1997: US05618920 (207 worldwide citation)

The invention relates to the secretion of heavy chain immunoglobulin fragments and light chain immunoglobulins from prokaryotic hosts using a prokaryotic secretion signal peptide wherein the heavy chain fragments and light chains are capable of associating to form an antigen binding antibody fragmen ...


3
Randy R Robinson, Alvin Y Liu, Arnold H Horwitz, Marc Better, Randolph Wall, Shau Ping Lei, Gary L Wilcox: Modular assembly of antibody genes, antibodies prepared thereby and use. XOMA, Sterne Kessler Goldstein & Fox P L L C, March 20, 2001: US06204023 (163 worldwide citation)

The invention relates to cDNA genetic sequences, vehicles containing same as well as hosts tansformed therewith, for the production of chimeric immunoglobulin molecules, functional fragments thereof and immunoglobulin derivatives exhibiting novel functional properties comprising human constant regio ...


4
Marc D Better, Arnold H Horwitz, Randy R Robinson, Shau Ping Lei, Changtung P Chang: Production of chimeric mouse-human antibodies with specificity to human tumor antigens. Xoma Corporation, Sterne Kessler Goldstein & Fox P L L C, November 19, 1996: US05576184 (133 worldwide citation)

Gene expression elements and their use in production of chimeric antibodies with human constant regions and murine variable regions, and mouse human chimeric antibodies having specificity to human tumor cells, methods of their production, and their use.


5
Randy R Robinson, Alvin Y Liu, Jeffrey A Ledbetter: Chimeric antibody with specificity to human B cell surface antigen. Pharmaceutical Royalties L L C, Bioventure Investments kft, Testa Hurwitz & Thibeault, September 19, 2000: US06120767 (82 worldwide citation)

A chimeric antibody with human constant region and murine variable region, having specificity to a 35 kDA polypeptide (Bp35(CD20)) expressed on the surface of human B cells, methods of production, and uses.


6
Randy R Robinson, Alvin Y Liu, Jeffrey A Ledbetter: Chimeric antibody with specificity to human B cell surface antigen. XOMA Corporation, Sterne Kessler Goldstein & Fox p l l c, February 24, 1998: US05721108 (78 worldwide citation)

The present invention relates to a chimeric antibody molecule comprising two heavy chains and two light chains, each of the chains comprising a variable region and a human constant region, said antibody having specificity for the antigen bound by the 2H7 murine monoclonal antibody. The invention is ...


7
Randy R Robinson, Alvin Y Liu, Arnold H Horwitz, Marc Better, Randolph Wall, Shau Ping Lei, Gary L Wilcox: Modular assembly of antibody genes, antibodies prepared thereby and use. Xoma Corporation, Sterne Kessler Goldstein & Fox P L L C, December 2, 1997: US05693493 (74 worldwide citation)

The invention relates to cDNA genetic sequences, vehicles containing same as well as hosts transformed therewith, for the production of chimeric immunoglobulin molecules, functional fragments thereof and immunoglobulin derivatives exhibiting novel functional properties comprising human constant regi ...


8
Randy R Robinson, Alvin Y Liu, Arnold H Horwitz, Marc Better, Randolph Wall, Shau Ping Lei, Gary L Wilcox: Modular assembly of antibody genes, antibodies prepared thereby and use. Xoma Corporation, Sterne Kessler Goldstein & Fox P L L C, December 16, 1997: US05698417 (73 worldwide citation)

The invention relates to cDNA genetic sequences, vehicles containing same as well as hosts transformed therewith, for the production of chimeric immunoglobulin molecules, functional fragments thereof and immunoglobulin derivatives exhibiting novel functional properties comprising human constant regi ...


9
Randy R Robinson, Alvin Y Liu, Jeffrey A Ledbetter: Chimeric antibody with specificity to human B cell surface antigen. Xoma Corporation, Sterne Kessler Goldstein & Fox p l l c, October 14, 1997: US05677180 (70 worldwide citation)

The present invention relates to a eukaryotic host cell that contains DNA encoding a chimeric antibody molecule comprising two heavy chains and two light chains, each of the chains comprising a variable region and a human constant region, said antibody having specificity for the antigen bound by the ...


10
Randy R Robinson, Marc Better, Shau Ping Lei, Gary L Wilcox: Vectors with pectate lyase signal sequence. Xoma Corporation, Sterne Kessler Goldstein & Fox P L L C, November 19, 1996: US05576195 (62 worldwide citation)

The invention relates to DNA coding for a pectate lyase signal peptide which has been inserted into plasmids to create secretion vectors which are capable of producing a chosen protein by directing transport across the bacterial membrane. The secretion vectors have been used to secrete extracellular ...