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Olaf B Kinstler, Nancy E Gabriel, Christine E Farrar, Randolph B DePrince: N-terminally chemically modified protein compositions and methods. Amgen, Robert B Winter, Karol M Pessin, Steven M Odre, October 20, 1998: US05824784 (274 worldwide citation)

Provided herein are methods and compositions relating to the attachment of water soluble polymers to proteins. Provided are novel methods for N-terminally modifying proteins or analogs thereof, and resultant compositions, including novel N-terminally chemically modified G-CSF compositions and relate ...


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Olaf B Kinstler, Nancy E Gabriel, Christine E Farrar, Randolph B DePrince: N-terminally chemically modified protein compositions and methods. Amgen, Craig A Crandall, Ron K Levy, Steven M Odre, November 16, 1999: US05985265 (88 worldwide citation)

Provided herein are methods and compositions relating to the attachment of water soluble polymers to proteins. Provided are novel methods for N-terminally modifying proteins or analogs thereof, and resultant compositions, including novel chemically modified G-CSF compositions and related methods of ...


3
William J Dower, Ronald W Barrett, Steven E Cwirla, Christian M Gates, Peter J Schatz, Palaniappan Balasubramanian, Christopher R Wagstrom, Richard Wayne Hendren, Randolph B Deprince, Surekha Podduturi, Qun Yin: Peptides and compounds that bind to a receptor. Glaxo Group, Virginia C Bennett, June 26, 2001: US06251864 (67 worldwide citation)

Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusi ...


4
Randolph B DePrince, Ravi Viswanathan: Stabilized porcine growth hormone. International Minerals & Chemical, Wendell R Guffey, Thomas L Farquer, George R Repper, August 23, 1988: US04765980 (65 worldwide citation)

Porcine serum albumin stabilizes porcine growth hormone, and provided for sustained release of porcine growth hormone in implant devices for swine.


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Ravi Viswanathan, Randolph B DePrince: Delivery device for the administration of stabilized growth promoting hormones. International Minerals & Chem, April 17, 1990: US04917685 (38 worldwide citation)

The present invention relates to a delivery device designed to be implanted in an animal and for the administration of a stabilized growth promoting formulation. This device has a wall formed at least in part by a porous membrane which surrounds and defines a reservoir. The reservoir contains a grow ...


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William J Dower, Ronald W Barrett, Steven E Cwirla, Christian M Gates, Peter J Schatz, Palaniappan Balasubramanian, Christopher R Wagstrom, Richard Wayne Hendren, Randolph B Deprince, Surekha Podduturi, Qun Yin: Peptides and compounds that bind to a receptor. Glaxo Wellcome, Virginia C Bennett, Frank P Grassler, September 19, 2000: US06121238 (32 worldwide citation)

Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusi ...


8
Olaf B Kinstler, Nancy Elise Gabriel, Christine E Farrar, Randolph B DePrince: N-terminally chemically modified protein compositions and methods. Amgen, Marshall Gerstein & Borun, February 16, 2010: US07662933 (29 worldwide citation)

Provided herein are methods and compositions relating to the attachment of water soluble polymers to proteins. Provided are novel methods for N-terminally modifying proteins or analogs thereof, and resultant compositions, including novel N-terminally chemically modified G-CSF compositions and relate ...


9
Randolph B DePrince: Disc-like sustained release formulation. International Minerals & Chemical, W R Guffey, T L Farquer, May 5, 1987: US04663147 (24 worldwide citation)

A device for the release of a diffusible solid in a fluid medium which comprises a disc which comprises a substantially uniform mixture of said diffusible solid and a polymer which is insoluble in and impermeable to said fluid medium and impermeable to said diffusible solid. The surfaces of said dis ...


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William J Dower, Ronald W Barrett, Steven E Cwirla, Christian M Gates, Peter J Schatz, Palaniappan Balasubramanian, Christopher R Wagstrom, Richard Wayne Hendren, Randolph B Deprince, Surekha Podduturi, Qun Yin: Labeled compounds that bind to a thrombopoietin receptor. Glaxo Group, Virginia C Bennett, January 14, 2003: US06506362 (20 worldwide citation)

Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusi ...