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Mark A Gallop, Xuedong Dai, Randall A Scheuerman, Stephen P Raillard, Suresh K Manthati, Fenmei Yao, Thu Phan, Maria Ludwikow, Ge Peng, Seema Bhat: Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof. XenoPort, Dorsey & Whitney, June 5, 2007: US07227028 (34 worldwide citation)

Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful int ...


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Mark A Gallop, Xuedong Dai, Randall A Scheuerman, Stephen P Raillard, Suresh K Manthati, Fenmei Yao, Thu Phan, Maria Ludwikow, Ge Peng, Seema Bhat: Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof. XenoPort, Dorsey & Whitney, March 31, 2009: US07511158 (12 worldwide citation)

Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful int ...


3
Randall A Scheuerman, Mark A Gallop, Kenneth C Cundy, Ronald W Barrett: Amino acid conjugates providing for sustained systemic concentrations of GABA analogues. XenoPort, Buchanan Ingersoll & Rooney PC, February 27, 2007: US07183259 (7 worldwide citation)

This invention is directed to compounds that provide for sustained systemic concentrations of GABA analogs following administration to animals. This invention is also directed to pharmaceutical compositions including and methods using such compounds.


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Mark Gallop, Kenneth C Cundy, Randall A Scheuerman, Ronald W Barrett, Noa Zerangue: Amino acid conjugates providing for sustained systemic concentrations of GABA analogues. Xenoport, Buchanan Ingersoll & Rooney P C, September 2, 2008: US07420002 (5 worldwide citation)

Compounds that provide for sustained systemic concentrations of GABA analogs following oral administration to animals are disclosed. Pharmaceutical compositions including, and methods using, such compounds are also disclosed.


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Mark A Gallop, Xuedong Dai, Randall A Scheuerman, Stephen P Raillard, Suresh K Manthati, Fenmei Yao, Thu Phan, Maria J Ludwikow, Ge Peng, Seema Bhat: Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof. XenoPort, Dorsey & Whitney, August 23, 2011: US08003809 (3 worldwide citation)

Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful int ...


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Stephen P Raillard, Randall A Scheuerman, Suresh K Manthati: Method of making monomethyl fumarate. XenoPort, Polsinelli PC, April 5, 2016: US09302977 (2 worldwide citation)

Methods of making monomethyl fumarate, which can then also be used in methods of making prodrugs of monomethyl fumarate, are disclosed. Monomethyl fumarate and prodrugs of monomethyl fumarate are useful for treating neurodegenerative, inflammatory, and autoimmune diseases including multiple sclerosi ...


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Mark A Gallop, Xuedong Dai, Randall A Scheuerman, Stephen P Raillard, Suresh K Manthati, Fenmei Yao, Thu Phan, Maria Ludwikow, Ge Peng, Seema Bhat: Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof. XenoPort, Dorsey & Whitney, February 19, 2013: US08378137 (2 worldwide citation)

Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful int ...


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Clive A Henrick, Randall A Scheuerman: Oxidation process. Syngenta Participations, William A Teoli Jr, August 14, 2001: US06274776 (1 worldwide citation)

Preparation of 2,5-dichlorophenol by selectively oxidizing 1,4-dichlorobenzene using a peroxo-, hydroperoxo-, superoxo- or alkylperoxo-metal species in the presence of an &agr;-hydroxy-, dibasic-, tribasic- or sulfonic acid.


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Chen Mao, Randall A Scheuerman, Sami Karaborni: Crystalline forms of (N,N-Diethylcarbamoyl)methyl methyl (2E)but-2-ene-1,4-dioate, methods of synthesis and use. XenoPort, Polsinelli PC, August 16, 2016: US09416096

Disclosed herein are crystalline forms of (N,N-Diethylcarbamoyl)methyl methyl (2E)but-2-ene-1,4-dioate, which is a prodrug of methyl hydrogen fumarate. Crystalline form 1, Crystalline form 2, Crystalline 3, and Crystalline form 4 are disclosed.