1
Markus F Renschler, Ronald Levy, Ramesh R Bhatt, William J Dower: Receptor-binding antiproliferative peptides. Tracy J Dunn, April 30, 1996: US05512435 (14 worldwide citation)

Methods and composition are provided for identifying antiproliferative polypeptides which inhibit clonal expansion and/or induce apoptosis in cells of a predetermined cell population (e.g., a neoplastic cell sample) expressing a cell surface receptor which is a member of the immunoglobulin superfami ...


2
Arun K Kashyap, Ramesh R Bhatt, Michael Horowitz, Lawrence Horowitz, Sihong Zhou, Ryann E O Neil, Charles H Hannum, Aaron L Kurtzman, Li Xu: Surrogate binding proteins which bind DR4 and/or DR5. i2 PHARMACEUTICALS, Cooley, May 22, 2018: US09975956

Embodiments concern constructs comprising surrogate light chain sequences. In particular, embodiments concern constructs that can bind to DR4 and/or DR5 and aspects relating to such constructs and their use.


3
Guido Cappuccilli, Roberto Crea, Takeuchi Toshihilo, Randy Shen, Ramesh R Bhatt, Nurten Beyaz Kavuncu: Antibody ultrahumanization by predicted mature CDR blasting and cohort library generation and screening. Bioren, Pfizer, May 6, 2014: US08716195

Methods and compositions directed to improved universal antibody libraries that rationally exploit human diversity information contained within reference antibody libraries, such as universal antibody libraries, are disclosed. The disclosed processes involve use of a query CDR sequence to guide inco ...


4
Lawrence Horowitz, Ramesh R Bhatt: Expression of surrogate light chains. Sea Lane Biotechnologies, Ginger Dreger, Gabor Brasnjo, Arnold & Porter, March 3, 2015: US08969082

The present invention concerns surrogate light chain (SURROBODY™) constructs comprising surrogate light chain sequences with heterologous signal sequences.


5
Lawrence Horowitz, Ramesh R Bhatt: Expression of surrogate light chains. Arnold & Porter, December 30, 2010: US20100330676-A1

The present invention concerns surrogate light chain (SURROBODY™) constructs comprising surrogate light chain sequences with heterologous signal sequences.


6
Lawrence Horowitz, Ramesh R Bhatt, Aaron L Kurtzman: Combinatorial libraries of conformationally constrained polypeptide sequences. Goodwin Procter, January 7, 2010: US20100004134-A1

The present invention concerns combinatorial libraries of conformationally constrained polypeptide sequences and their uses. In particular, the present invention concerns combinatorial libraries of conformational epitopes and their uses.


7
Ramesh R Bhatt, Lawrence Horowitz: Constructs and libraries comprising antibody surrogate kappa light chain sequences. Goodwin Procter, March 11, 2010: US20100062950-A1

The present invention concerns constructs and libraries comprising antibody surrogate κ light chain sequences. In particular, the invention concerns constructs comprising antibody surrogate κ light chain sequences, optionally partnered with another polypeptide, such as, for example, antibody heavy a ...