1
Toufike Kanouni
Qing Dong, Toufike Kanouni, Michael B Wallace: MAPK/ERK kinase inhibitors. Takeda Pharmaceutical Company, David M Stemerick, Mitchell R Brustein, September 20, 2011: US08022057 (1 worldwide citation)

Compounds of the following formula are provided for use with MEK: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using sa ...


2
Toufike Kanouni
Qing Dong, Toufike Kanouni, John David Lawson, Michael B Wallace: Dihydropyrrolonaphthyridinone compounds as inhibitors of JAK. Takeda Pharmaceutical Company, Matthew J Russo, David M Stemerick, April 16, 2013: US08420816

Disclosed are JAK inhibitors of formula I where G1, R1, R2, R3, R4, R5, R6, and R7 are defined in the specification. Also disclosed are pharmaceutical compositions, kits and articles of manufacture which contain the compounds, methods and materials for making the compounds, and methods of using the ...


3
Toufike Kanouni
Qing Dong, Xianchang Gong, Stephen W Kaldor, Toufike Kanouni, Nicholas Scorah, Michael B Wallace, Feng Zhou: MAPK/ERK KINASE INHIBITORS. TAKEDA PHARMACEUTICAL COMPANY, TAKEDA SAN DIEGO, May 27, 2010: US20100130518-A1

Compounds of the following formula are provided for use with MEK (I): wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of usin ...


4
Toufike Kanouni
Qing Dong, Xianchang Gong, Stephen W Kaldor, Toufike Kanouni, Nicholas Scorah, Michael B Wallace, Feng Zhou: Mapk/erk kinase inhibitors. Takeda San Diego, October 16, 2008: US20080255160-A1

Compounds of the following formula are provided for use with MEK: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using sa ...


5
Toufike Kanouni
Qing Dong, Toufike Kanouni, John David Lawson, Michael B Wallace: Dihydropyrrolonaphtyridinone compounds as inhibitors of jak. Takeda Pharmaceutical Company, June 9, 2011: US20110136780-A1

Disclosed are JAK inhibitors of formula I where G1, R1, R2, R3, R4, R5, R6, and R7 are defined in the specification. Also disclosed are pharmaceutical compositions, kits and articles of manufacture which contain the compounds, methods and materials for making the compounds, and methods of using the ...


6
Toufike Kanouni
MarK Adams, Qing Dong, Toufike Kanouni, Stephen W Kaldor, Nicholas Scorah, Michael B Wallace: Mapk/erk kinase inhibitors. Takeda Pharmaceutical Company, Takeda San Diego, May 14, 2009: US20090124595-A1

Compounds of the following formula are provided for use with MEK: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using sa ...


7
Qing Dong, Jianqiang Wang, Hengyuan Lang, Jiong Lan: Substituted pyrazolo [3,4-d]pyrimidines as cytokine modulators. Novartis, Mark W Milstead, August 4, 2009: US07569571 (51 worldwide citation)

Provided are bicyclic heterocycle-based p38 kinase, including p38α and p38β kinase, inhibitors. Pharmaceutical compositions containing the compounds are also provided. Methods of use of the compounds and compositions are also provided, including methods of treatment, prevention, or amelioration of o ...


8
Upul K Bandarage, Qing Dong, Xinqin Fang, David S Garvey, Gregory J Mercer, Stewart K Richardson, Joseph D Schroeder, Tiansheng Wang: Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use. NitroMed, Hale and Dorr, October 2, 2001: US06297260 (37 worldwide citation)

The present invention describes novel nitrosated and/or nitrosylated nonsteroidal antiinflammatory compounds, and novel compositions comprising at least one nitrosated and/or nitrosylated nonsteroidal antiinflammatory compound, and, optionally, at least one compound that donates, transfers or releas ...


9
Qing Dong: Flat knitted stent and method of making the same. Scimed Life Systems, Hoffmann & Baron, March 14, 2006: US07011676 (31 worldwide citation)

A knitted implantable stent having a hollow tubular structure having opposed open ends defining a wall portion therebetween is provided. The wall portion includes an open lattice structure of a plurality of interconnected perimetrically bound cells. The cells are defined by a plurality cell segments ...


10
Wei Zhong Li, Vincent Au Yeung, Qing Dong Guo: Optical circulator. U Kaifa Technology, Lumen Intellectual Property Services, July 27, 1999: US05930039 (20 worldwide citation)

An improved optical circulator transfers light from a first optical port to a second optical port, and from the second port to a third port. The circulator has reciprocal and non-reciprocal polarization rotators, birefringent beam splitters and combiners, and a birefringent walk-off element as well ...