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Edge Albert, Seyb Kathleen, Glicksman Marcie, Qiao Lixin, Cuny Gregory D, Jeon Sang Jun: Compounds that enhance atoh-1 expression. Massachusetts Eye & Ear Infirmary, The Brigham And Women S Hospital, Edge Albert, Seyb Kathleen, Glicksman Marcie, Qiao Lixin, Cuny Gregory D, Jeon Sang Jun, FREEMAN John Wet al, August 13, 2009: WO/2009/100438 (13 worldwide citation)

This invention generally provides compounds, pharmaceutical compositions, and methods for their use, which include methods that result in increased expression in an Atoh1 gene (e.g., Hath1) in a biological cell. More specifically, the invention relates to the treatment of diseases and/or disorders t ...


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QIAO LIXIN: Inhibiting eph b-3 kinase. The Brigham And Women S Hospital, Goodson Susanne H, October 14, 2010: WO/2010/117787 (4 worldwide citation)

EphB3 kinase inhibitor compounds, including certain pyrazolo[1,5-a]pyridine and imidazo[1,2-a]pyridine compounds, inhibit EphB3 kinase. The EphB3 kinase inhibitor compounds can have greater potency for the inhibition of EphB3 kinase than general kinase inhibitors. Pharmaceutical compositions, such a ...


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Carter Stephen G, Patel Kanu, Zhu Zhen, Qiao Lixin: Bifunctional synthetic molecules. Biochemics, Carter Stephen G, Patel Kanu, Zhu Zhen, Qiao Lixin, LEMACK Kevin S, December 24, 2008: WO/2008/156758 (2 worldwide citation)

The synthesis and use of bifunctional molecules to improve the topical and transdermal delivery efficiency of various types of therapeutic agents or agents designed to promote the transdermal delivery of those therapeutic agents either into the skin tissue or into the systemic circulation. Three maj ...


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Alan P Kozikowski, Wang Shaomeng, Qiao Lixin: Substituted 2-pyrolidinone activators of pkc. Georgetown Univ, li yue, October 25, 2000: CN98808698

Compounds of formula (I) wherein R1 and R2 are each independently (C1-C15)alkyl, (C2-C15)alkenyl, (C2-C15)alkynyl, (C3-C8)cycloalkyl, (C3-C8)cycloalkyl(C1-C10)alkyl, (C3-C8)cycloalkyl(C1-C15)alkenyl, (C3-C8)cycloalkyl(C1-C15)alkynyl, (C1-C15)alkoxy, (C1-C15)alkanoyl, (C1-C15)alkanoyloxy, aryl, heter ...