1
Joseph J Nunes, Jill Milne, Jean Bemis, Roger Xie, Chi B Vu, Pui Yee Ng, Jeremy S Disch: Sirtuin modulating compounds. Sirtris Pharmaceuticals, Ropes & Gray, March 18, 2008: US07345178 (45 worldwide citation)

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to agin ...


2
Jean Bemis, Jeremy S Disch, Michael Jirousek, Walter Joseph Lunsmann, Pui Yee Ng, Chi B Vu: Sirtuin modulating compounds. Sirtris Pharmaceuticals, Ropes & Gray, November 9, 2010: US07829556 (38 worldwide citation)

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to agin ...


3
Jean Bemis, Jeremy S Disch, Pui Yee Ng, Christopher Oalmann, Robert B Perni, Chi B Vu: Sirtuin modulating compounds. Sirtris Pharmaceuticals, Ropes & Gray, February 22, 2011: US07893086 (18 worldwide citation)

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to agin ...


4
Joseph J Nunes, Jill Milne, Jean Bemis, Roger Xie, Chi B Vu, Pui Yee Ng, Jeremy S Disch, Thomas Salzmann, David Armistead: Sirtuin modulating compounds. Sirtris Pharmaceuticals, Ropes & Gray, December 21, 2010: US07855289 (18 worldwide citation)

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to agin ...


5
Joseph J Nunes, Jill Milne, Jean Bemis, Roger Xie, Chi B Vu, Pui Yee Ng, Jeremy S Disch: Sirtuin modulating compounds. Sirtris Pharmaceuticals, Ropes & Gray, January 10, 2012: US08093401 (17 worldwide citation)

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to agin ...


6
Joseph J Nunes, Jill Milne, Jean Bemis, Roger Xie, Chi B Vu, Pui Yee Ng, Jeremy S Disch, Thomas Salzmann, David Armistead: Sirtuin modulating compounds. Sirtris Pharmaceuticals, Ropes & Gray, January 3, 2012: US08088928 (17 worldwide citation)

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to agin ...


7
Joseph J Nunes, Jill Milne, Jean Bemis, Roger Xie, Chi B Vu, Pui Yee Ng, Jeremy S Disch: Sirtuin modulating compounds. Sirtris Pharmaceuticals, Ropes & Gray, October 25, 2011: US08044198 (13 worldwide citation)

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to agin ...


8
Jean Bemis, Jeremy S Disch, Pui Yee Ng, Christopher Oalmann, Robert B Perni, Chi B Vu: Sirtuin modulating compounds. Sirtris Pharmaceuticals, Ropes & Gray, James T Olesen, Jeffrey A Sutton, September 18, 2012: US08268862 (1 worldwide citation)

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to agin ...


9
Joseph J Nunes, Jill Milne, Jean Bemis, Roger Xie, Chi B Vu, Pui Yee Ng, Jeremy S Disch, Thomas Salzmann, David Armistead: Sirtuin modulating compounds. Sirtris Pharmaceuticals, Ropes & Gray, May 15, 2012: US08178536 (1 worldwide citation)

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to agin ...


10
Kenneth W Bair, Nicholas Barczak, Bingsong Han, David R Lancia Jr, Cuixian Liu, Matthew W Martin, Pui Yee Ng, Aleksandra Rudnitskaya, Jennifer R Thomason, Mary Margaret Zablocki, Xiaozhang Zheng: Alpha-cinnamide compounds and compositions as HDAC8 inhibitors. Forma Therapeutics, Cooley, August 29, 2017: US09745253

The present invention relates to inhibitors of histone deacetylases, in particular HDAC8, that are useful for the treatment of cancer and other diseases and disorders, as well as the synthesis and applications of said inhibitors.