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Prasit Petpiboon, Fortin Rejean, Hutchinson John H, Belley Michel L, Leger Serge, Gillard John, Frenette Richard: (Quinolin-2-ylmethoxy) indoles as inhibitors of the biosynthesis of leukotrienes.. Merck Frosst Canada, March 27, 1991: EP0419049-A1 (82 worldwide citation)

Compounds having the formula I: are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labo ...


2
Zamboni Robert, Prasit Petpiboon, Young Robert N: Quinoline ether alkanoic acid.. Merck Frosst Canada, January 3, 1990: EP0349062-A1 (57 worldwide citation)

Compounds having the formula: are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labor, ...


3
Prasit Petpiboon, Hutchinson John H, Therien Michel, Gillard John W, Frenette Richard: (Azaarylmethoxy)Indoles as inhibitors of leukotriene biosynthesis.. Merck Frosst Canada, April 7, 1993: EP0535923-A1 (17 worldwide citation)

Compounds having the formula I: are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labo ...


4
Hutchinson John H, Prasit Petpiboon Peppi, Moran Mark, Evans Jillian F, Zunic Jasmine Eleanor, Stock Nicholas Simon: (flap) Inhibitors. Amira Pharmaceuticals, Hutchinson John H, Prasit Petpiboon Peppi, Moran Mark, Evans Jillian F, Zunic Jasmine Eleanor, Stock Nicholas Simon, HOSTETLER Michael J, April 26, 2007: WO/2007/047207 (15 worldwide citation)

Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of 5-lipoxygenase-activating protein (FLAP). Also described herein are methods of using such FLAP modulators, alone and in combination with other compounds, for treating respiratory, ...


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Munoz Benito, Prasit Petpiboon, Stock Nicholas Simon: Geminally di-substituted nsaid derivatives as abeta 42 lowering agents. Merck & Co, Munoz Benito, Prasit Petpiboon, Stock Nicholas Simon, MERCK 126 East Lincoln Avenue Rahway NJ 07065 0907, August 5, 2004: WO/2004/064771 (9 worldwide citation)

The present invention encompasses compounds of Formula I (I) or pharmaceutically acceptable salts thereof, wherein A is the base molecule of a propionic acid or acetic acid NSAID, or a derivative thereof, X is -CO2H, 1H-tetrazol-5-yl or 2H-tetrazol-5-yl and R1 and R2 are each independently selected ...


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Ducharme Yves, Gauthier Jacques Yves, Prasit Petpiboon, Leblanc Yves, Wang Zhaoyin, Leger Serge, Therien Michel: Phenyl heterocycles as cyclooxygenase-2 inhibitors. Merck Frosst Canada, January 22, 1997: EP0754687-A1 (7 worldwide citation)

The invention encompasses the novel compound of formula (I) useful in the treatment of cyclooxygenase-2 mediated diseases. The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of formula (I).


9
Black Cameron, Mancini Joseph A, Lau Cheuk Kun, Prasit Petpiboon, Vickers Philip J: Pharmaceutically active n-acylindoles. Merck Frosst Canada, May 17, 1995: GB2283745-A (6 worldwide citation)

Compounds of the structure shown below and pharmaceutically acceptable salts thereof are specific inhibitors of cyclooxygenase-2 useful in the treatment of cyclooxygenase-2 mediated disease states such as inflammation, pain and fever, and are non-ulcerogenic: R is -OCH3, -N(CH3)2, -SCH3, -OCF3, halo ...


10
Hutchinson John H, Prasit Petpiboon Peppi, Moran Mark, Evans Jillian F, Stearns Brian Andrew, Roppe Jeffrey Roger, Li Yiwei, Zunic Jasmine Eleanor, Arruda Jeannie M, Stock Nicholas Simon, Haddach Mustapha: (flap) Inhibitors. Amira Pharmaceuticals, Hutchinson John H, Prasit Petpiboon Peppi, Moran Mark, Evans Jillian F, Stearns Brian Andrew, Roppe Jeffrey Roger, Li Yiwei, Zunic Jasmine Eleanor, Arruda Jeannie M, Stock Nicholas Simon, Haddach Mustapha, HOSTETLER Michael J, May 18, 2007: WO/2007/056021 (6 worldwide citation)

Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of 5-lipoxygenase-activating protein (FLAP). Also described herein are methods of using such FLAP modulators, alone and in combination with other compounds, for treating respiratory, ...