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Prakash Thazha P, Swayze Eric E, Bhat Balkrishen: N-substituted-aminomethylene bridged bicyclic nucleic acid analogs. Isis Pharmaceuticals, Prakash Thazha P, Swayze Eric E, Bhat Balkrishen, PATHAK Rahul, December 11, 2008: WO/2008/150729 (86 worldwide citation)

Provided herein are bicyeMc nucleosides comprising a substituted amino group in the bridge, oligomeric compounds having at least one of these bi cyclic nucleosides and methods of using the oligomeric compounds. The bicyclic nucleosides comprising a substituted amino group in the bridge are useful fo ...


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Bhat Balkrishen, Carroll Steven S, Eldrup Anne B, Maccoss Malcolm, Olsen David B, Prakash Thazha P: Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase. Merck & Co, Isis Pharmaceuticals, Bhat Balkrishen, Carroll Steven S, Eldrup Anne B, Maccoss Malcolm, Olsen David B, Prakash Thazha P, MERCK 126 East Lincoln Avenue Rahway NJ 07065 0907, January 22, 2004: WO/2004/007512 (75 worldwide citation)

The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are partic ...


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Bhat Balkrishen, Prakash Thazha P, Dande Prasad, Allerson Charles, Griffey Richard, Swayze Eric E: Double strand compositions comprising differentially modified strands for use in gene modulation. Isis Pharmaceuticals, Bhat Balkrishen, Prakash Thazha P, Dande Prasad, Allerson Charles, Griffey Richard, Swayze Eric E, CALDWELL John, December 22, 2005: WO/2005/121371 (70 worldwide citation)

The present invention provides douse stranded compositions wherein each strand is modified to have a motif defined by positioning of ß-D-ribonucleosides and sugar modified nucleosides. More particularly, the present compositions comprise one strand having a gapped motif and another strand having a g ...


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Bhat Balkrishen, Prakash Thazha P, Dande Prasad, Allerson Charles, Griffey Richard H, Swayze Eric E: Double strand compositions comprising differentially modified strands for use in gene modulation. Isis Pharmaceuticals, Bhat Balkrishen, Prakash Thazha P, Dande Prasad, Allerson Charles, Griffey Richard H, Swayze Eric E, CALDWELL John, December 22, 2005: WO/2005/121372 (25 worldwide citation)

The present invention provides double stranded compositions wherein each strand is modified to have a motif defined by positioning of &bgr;-D-ribonucleosides and sugar modified nucleosides. More particularly, the present compositions comprise one strand having an alternating motif and another strand ...


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PRAKASH Thazha P, SETH Punit P, SWAYZE Eric E: [fr] COMPOSÉS ANTISENS CONJUGUÉS ET LEUR UTILISATION, [en] CONJUGATED ANTISENSE COMPOUNDS AND THEIR USE. ISIS PHARMACEUTICALS, STRAHER Michael P, November 6, 2014: WO/2014/179620 (18 worldwide citation)

[en] Provided herein are oligomeric compounds with conjugate groups. In certain embodiments, the oligomeric compounds are conjugated to N-Acetylgalactosamine.


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PRAKASH Thazha P, SETH Punit P, SWAYZE Eric E: Nucléosides modifiés et composés oligomères préparés à partir de ceux-ci, Modified nucleosides and oligomeric compounds prepared therefrom. Isis Pharmaceuticals, PRAKASH Thazha P, SETH Punit P, SWAYZE Eric E, RIEGER Dale, November 10, 2011: WO/2011/139702 (16 worldwide citation)

The present invention provides modified nucleosides, analogs thereof and oligomeric compounds prepared therefrom. More particularly, the present invention provides modified nucleosides and analogs thereof that are useful for incorporation at the terminus of an oligomeric compound. Such oligomeric co ...


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PRAKASH Thazha P, SETH Punit P, SWAYZE Eric E, GRAHAM Mark J: [fr] COMPOSITIONS ET PROCÉDÉS DE MODULATION DE LEXPRESSION DE LAPOLIPOPROTÉINE C-III, [en] COMPOSITIONS AND METHODS FOR MODULATING APOLIPOPROTEIN C-III EXPRESSION. ISIS PHARMACEUTICALS, LIANG Teresa Y, November 6, 2014: WO/2014/179626 (15 worldwide citation)

[en] Provided herein are oligomeric compounds with conjugate groups targeting apoplipoprotein C-III (ApoClll). In certain embodiments, the ApoClll targeting oligomeric compounds are conjugated to N-Acetylgalactosamine. Also disclosed herein are conjugated oligomeric compounds targeting ApoClll for u ...


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PRAKASH THAZHA P: 5 and 2 bis-substituted nucleosides and oligomeric compounds prepared therefrom. ISIS PHARMACEUTICALS, Rieger Dale L, April 29, 2010: WO/2010/048549 (12 worldwide citation)

The present invention provides modified nucleosides and oligomeric compounds prepared therefrom. More particularly, the present invention provides modified nucleosides having at least one 5'-substituent and a 2'-O-substituent, oligomeric compounds comprising at least one of these modified nucleoside ...