1
Prabhakar R Sheth, Jacques L Tossounian: Novel sustained release tablet formulations. Hoffmann La Roche, Jon S Saxe, George M Gould, R Hain Swope, September 11, 1979: US04167558 (95 worldwide citation)

A novel sustained release formulation for the preparation of tablets for oral administration is disclosed. The formulation is hydrodynamically balanced to be buoyant in gastric juice thereby remaining in the stomach for an extended period of time.


2
Prabhakar R Sheth, Jacques L Tossounian: Sustained release tablet formulations. Hoffmann La Roche, Jon S Saxe, George M Gould, R Hain Swope, February 20, 1979: US04140755 (81 worldwide citation)

A novel sustained release formulation for the preparation of tablets for oral administration is disclosed. The formulation is hydrodynamically balanced to be buoyant in gastric juice thereby remaining in the stomach for an extended period of time.


3
Prabhakar R Sheth, Jacques L Tossounian: Hydrodynamically balanced controlled release compositions containing L-dopa and a decarboxylase inhibitor. Hoffmann La Roche, Jon S Saxe, George M Gould, John J Maitner, January 3, 1984: US04424235 (35 worldwide citation)

Hydrodynamically balanced controlled release compositions for the preparation of pharmaceutical capsules or tablets which contain L-Dopa and a decarboxylase inhibitor and which provide superior blood levels of L-Dopa are disclosed.


4
Prabhakar R Sheth, Jacques L Tossounian: Sustained release pharmaceutical capsules. Hoffmann La Roche, Jon S Sax, Bernard S Leon, R Hain Swope, November 21, 1978: US04126672 (29 worldwide citation)

Sustained release pharmaceutical capsules suitable for oral administration and particularly suitable for sustained release therapy with certain benzodiazepines, e.g. chlordiazepoxide and diazepam, are disclosed. The formulation contained in the disclosed capsules is hydrodynamically balanced to be b ...


5
William J Mergens, Harold L Newmark, Prabhakar R Sheth, Jacques L Tossounian: Prevention of N-nitroso compound formation in vivo. Hoffman La Roche, Jon S Saxe, George M Gould, Norman C Dulak, July 21, 1987: US04681756 (5 worldwide citation)

The effect of a controlled release, hydrodynamically balanced dosage formulation containing both an aqueous phase N-nitroso compound blocking agent and a lipid phase N-nitroso compound blocking agent in preventing the formation of nitrosamines and nitrosamides in the stomach is disclosed.


6
Prabhakar R Sheth: Method of manufacturing an antihypertensive, diuretic and antihypokalemic pharmaceutical composition with polyethylene glycol. December 27, 1988: US04793999 (4 worldwide citation)

A novel method of manufacturing a novel effective antihypertensive, diuretic and antihypokalemic pharmaceutical composition in which a triamterene active pteridine, a hydrochlorothiazide active benzothiadiazide, and a filler are thoroughly mixed with a polyethylene glycol, applying heat to the melti ...


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