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O& 039, Brien Michael K, Garcia Herve, Leon Patrick, Powner Tory H, Reilly Laurence W, Shah Harshavadan C, Thompson Michael D, Tsuei Ching T, Vanasse Benoit J, Walther Francis L: Preparation of not 1s- not 1a,2b,3b,4a(s*) -4- not 7- not not 1-(3-chloro-2-thienyl)methy propy amino -3h-imidazo not 4,5-b pyridin-3-y -n-ethyl-2,3-dihydroxycyclopentanecarboxamide. Aventis Pharma, December 28, 2005: EP1609791-A1

This invention is directed to methods for the preparation of Ä1S-Ä1a,2b,3b,4a(S*)ÜÜ-4-Ä7-ÄÄ1-(3-chloro-2-thienyl)methylÜpropylÜaminoÜ-3H-imidazoÄ4,5-bÜpyridi n-3-ylÜ-N-ethyl-2,3-dihydroxycyclopentanecarboxamide, methods for the preparation of intermediates thereto, and to said intermediates themselv ...


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O& 039, Brien Michael K, Garcia Herve Rhone Poulenc Ind, Leon Patrick, Powner Tory H, Reilly Laurence W, Shah Harshavadan C, Thompson Michael D, Tsuei Ching T, Vanasse Benoit J, Walther Francis L: Preparation of [1s-[1a,2b,3b,4a(s*)]]-4-[7-[[1-(3-chloro-2-thienyl)methyl]propyl]amino]-3h-imidazo[4,5-b]pyridin-3-yl]-n-ethyl-2,3-dihydroxycyclopentanecarboxamide. Rhone Poulenc Rorer Pharma, October 6, 1999: EP0946550-A1

This invention is directed to methods for the preparation of [1S-[1a,2b,3b,4a(S*)] ]-4-[7-[[1-(3-chloro-2-thienyl)methyl]propyl]amino]-3H-imidazo[4,5-b]pyridin-3-yl]-N-ethyl-2, 3-dihydroxycyclopentanecarboxamide, methods for the preparation of intermediates thereto, and to said intermediates themsel ...


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Chandramouli Sithamalli V, O Brien Michael K, Powner Tory H: $G(a)-substitution of unprotected $g(b)-amino ester compounds. Aventis Pharmaceuticals Products, Chandramouli Sithamalli V, O Brien Michael K, Powner Tory H, OEHLER Ross J, July 13, 2000: WO/2000/040547

Methods for stereoselective substitution in which a (mono or un)-$g(a)-substituted unprotected $g(b)-amino ester compound or salt thereof is reacted with an aliphatic electrophile in the presence of a base selected from alkyl lithium compounds, lithium hybride, lithium amide, lithium dialkyl amides ...


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Chandramouli Sithamalli V, O& 039, Brien Michael K, Powner Tory H: Alpha-substitution of unprotected beta-amino ester compounds. Aventis Pharm Prod, October 17, 2001: EP1144367-A1

Methods for stereoselective substitution in which a (mono or un)- alpha -substituted unprotected beta -amino ester compound or salt thereof is reacted with an aliphatic electrophile in the presence of a base selected from alkyl lithium compounds, lithium hybride, lithium amide, lithium dialkyl amide ...


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Sledeski Adam W, Grondard Luc, Powers Matthew R, Powner Tory H, O& 039, Brien Michael K, Tsuei Ching T, Leon Patrick, Kubiak Gregory G, Pailleres Hubert Laurence, Viguier Benoit: Process for preparing n6-substituted deaza-adenosine derivatives. Aventis Pharmacueticals Produc, October 10, 2001: EP1140933-A2

This invention is directed to a process for preparing N6-substituted adenosine derivatives, to intermediates useful therefor and to methods of preparing these intermediates.


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