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Wallace Donald G, Piez Karl A, Smestad Thomas L, Seyedin Saeid, Mcpherson John M, Armstrong Rosa: Bone repair using collagen.. Collagen, February 12, 1986: EP0171176-A2 (44 worldwide citation)

A composition for repairing bone defects by use of suspensions containing purified atelopeptide, reconstituted, fibrillar skin collagen or bone collagen powder or a mixture thereof is disclosed. The suspensions provide matrices for conductive growth of bone into the defect. The skin collagen may als ...


2
Clark Richard A, Piez Karl A: Collagen matrix for tissue repair.. Nat Jewish Hospital And Resear, October 9, 1985: EP0157359-A2 (24 worldwide citation)

A biological matrix is provided comprising a non-immunogenic atelopeptide collagen. The biological matrix is useful as a closure for gaping wounds since it allows angiogenesis and fibroplasia while being incorporated into the wound be re-epithelialization. In a medical treatment a gaping wound is pa ...


3
Piez Karl A, Pharriss Bruce B, Chu Georges H, Smestad Thomas L, Hendricks Diana: Xenogeneic collagen/mineral preparations in bone repair.. Collagen, October 15, 1986: EP0197693-A2 (21 worldwide citation)

A composition for use in bone repair, in particular, in onlay procedures, which comprises calcium phosphate minerals in admixture with atelopeptide reconstituted fibrillar collagen preparations is disclosed. This composition is non-immunogenic and encourages the fusion of host bone with new bone gro ...


4
Piez Karl A, Parr Jack E: A marrow/collagen/mineral matrix for bone defect repair.. Collagen, October 28, 1987: EP0243178-A2 (17 worldwide citation)

A method and composition for repair of bone defects employs a matrix which consists of bone marrow extended and strengthened with a mixture of reconstituted fibrillar collagen and a calcium phosphate mineral.


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Mcpherson John M, Twardzik Daniel R, Todaro George J, Piez Karl A, Ranchalis Jane E: Use of cartilage-inducing factor b (cif-b) for the manufacture of a medicament for inhibiting tumor growth.. Collagen, Oncogen, June 15, 1988: EP0271211-A2 (10 worldwide citation)

A polypeptide called cartilage-inducing factor B (CIF-B) or transforming growth factor beta 2 (TGF- beta 2) that is found in bone and has heretofore been identified as having in vitro cartilage-inducing activity, TGF- beta activity, and anti-inflammatory activity has now been found to possess potent ...


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Wallace Donald G, Piez Karl A, Smestad Thomas L, Armstrong Rosa, Seyedin Saeid, Mcpherson John M: Bone repair using collagen.. Collagen, May 29, 1991: EP0429438-A2 (8 worldwide citation)

A composition for repairing bone defects by use of suspensions containing purified atelopeptide, reconstituted fibrillar skin collagen is disclosed. The suspensions provide matrices for conductive growth of bone into the defect. The skin collagen may also be lyophilized and used in the form of mats ...


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Piez Karl A, Pharriss Bruce B, Smestad Thomas L, Chu George H, Hendricks Diana: Preparations collagene/mineral xenogeniques pour la reparation des os, Xenogeneic collagen/mineral preparations in bone repair. Collagen Corporation, SIM & MCBURNEY, September 26, 1989: CA1260391 (3 worldwide citation)

-20- Abstract A composition for use in bone repair, in particular, in onlay procedures, which comprises calcium phosphate minerals in admixture with atelopeptide reconstituted fibrillar collagen preparations is disclosed. This composition is non-immunogenic and encourages the fusion of host bone wit ...


9
Bentz Hanne, Nathan Ranga, Rosen David M, Dasch James R, Seyedin Saeid M, Piez Karl A, Ogawa Yasushi, Andrews William H, Stephenson Frank H, Hedgpeth Joel: Bone-specific protein.. Celtrix Lab, June 10, 1992: EP0489062-A1

Proteins, having sequence (I) where R is Ala ou Thr, R is Asn or His, R is Thr or Ser, R is Ala or Thr, R is Ile or Val, R is Val or Ile and R is Phe or Ile, is disclosed. These proteins are present in osteoblasts and osteocytes and may be used as markers to follow bone and/or cartilage metabolism.


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Mcpherson John M, Twardzik Daniel R, Todaro George J, Piez Karl A, Ranchalis Jane E: Composition inhibitrice de la croissance de tumeurs, Composition for inhibiting tumor growth. Celtrix Laboratories, Oncogen, Celtrix Pharmaceuticals, ADE & COMPANY, January 28, 1992: CA1294874

-16- A COMPOSITION FOR INHIBITING TUMOR GROWTH Abstract A polypeptide called cartilage-inducing factor(CIF-B) or transforming growth factor beta 2 (TGF-B2)that is found in bone and has heretofore been identifiedas having in vitro cartilage-inducing activity, TGF-Bactivity, and anti-inflammatory acti ...