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Patrick Aebischer, Shelley R Winn, Pierre M Galletti: In vivo delivery of neurotransmitters by implanted, encapsulated cells. Brown University Research Foundation, Thomas J Engellenner, Ann Louise Kerner, January 9, 1990: US04892538 (320 worldwide citation)

Methods and devices are disclosed for the delivery of a neurotransmitter from an implanted, neurotransmitter-secreting cell culture to a target region in a subject. The cell culture is maintained within a biocompatible, semipermeable membrane which permits the diffusion of the neurotransmitter there ...


2
Patrick Aebischer, Pierre M Galletti, George Panol, Luigi Miracoli: Implantable delivery system for biological factors. Brown University Research Foundation, Thomas J Engellener, April 30, 1991: US05011472 (209 worldwide citation)

Devices and methods are disclosed to provide hybrid, modular systems for the constitutive delivery of appropriate dosages of active factor to a subject and, in some instances, to specific anatomical regions of the subject. The systems include a cell reservoir containing living cells capable of secre ...


3
Patrick Aebischer, Robert F Valentini, Pierre M Galletti: Devices for neural signal transmission. Pfizer Hospital Products Group, Thomas J Engellenner, Ann L Kerner, November 7, 1989: US04878913 (83 worldwide citation)

Devices and methods for transmitting neural signals from a proximal stump of a transected nerve to a prosthetic apparatus are disclosed employing microelectrodes, preferably conductive fiber networks, capable of sensing electrical signals from a nerve and transmitting such signals to a prosthetic ap ...


4
Danilo E De Rossi, Pierre M Galletti, Paolo Dario: Catheter. Brown University Research Foundation, June 26, 1984: US04456013 (42 worldwide citation)

A catheter including a support suitable for insertion into a body organ, a transducer carried by the support, the transducer including a flexible piezoelectric polymeric membrane, and a pair of surface electrodes mounted on the membrane, the support including a rigid portion defining a flexure cavit ...


5
William L Chick, Pierre M Galletti, Peter D Richardson, Georg Panol: Cell culture device. December 30, 1980: US04242460 (33 worldwide citation)

A cell culture device for use, e.g., as an artificial pancreas, featuring, in various aspects, a semipermeable tube wrapped about a spool and mounted within a cylinder to form a cell culture compartment; an inlet and an outlet strand of the semipermeable tube being wrapped to form alternating adjace ...


6
Robert F Valentini, Patrick Aebischer, Pierre M Galletti: Semipermeable nerve guidance channels. Brown University Research Foundation, Thomas J Engellenner, Ann Louise Kerner, October 31, 1989: US04877029 (25 worldwide citation)

Medical devices employing semipermeable materials, such as acrylic copolymers, polyurethane isocyanate, and other biocompatible semipermeable polymers, are disclosed for use as guidance channels in regenerating nerves. The devices can be formed by tubular semipermeable conduits adapted to receive th ...


7
William L Chick, Pierre M Galletti, Peter D Richardson, Georg Panol: Cell culture device. December 30, 1980: US04242459 (23 worldwide citation)

A cell culture device for use, e.g., as an artificial pancreas, featuring, in various aspects, a tightly wound spiral tube snugly fit in a cavity to form a cell culture compartment, the spiral being eccentrically offset in the cavity to reduce the volume of the compartment, a sloped passage in the b ...


8
Patrick Aebischer, Shelley R Winn, Pierre M Galletti: In vivo delivery of neurotransmitters by implanted, encapsulated cells. Brown University Research Foundation, Ivor R Elrifi, Petrina S Hsi, Fish & Neave, November 4, 1997: USRE035653

Methods and devices are disclosed for the delivery of a neurotransmitter from an implanted, neurotransmitter-secreting cell culture to a target region in a subject. The cell culture is maintained within a biocompatible, semipermeable membrane which permits the diffusion of the neurotransmitter there ...


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