1
Philip L Felgner, Jon A Wolff, Gary H Rhodes, Robert W Malone, Dennis A Carson: Delivery of exogenous DNA sequences in a mammal. VICAL Incorporated, Wisconsin Alumni Research Foundation, Knobbe Martens Olson & Bear, December 3, 1996: US05580859 (755 worldwide citation)

Polynucleotide sequences, comprising DNA and RNA molecules can be directly administered, for example by injection, to tissues, such as muscle, and expressed as a protein, polypeptide or polypeptide. The polynucleotides can be contained within liposomes or the polynucleotides can free from associatio ...


2
Philip L Felgner, Jon A Wolff, Gary H Rhodes, Robert W Malone, Dennis A Carson: Induction of a protective immune response in a mammal by injecting a DNA sequence. Vical Incorporated, Wisconsin Alumni Research Foundation, Knobbe Martens Olson & Bear, December 31, 1996: US05589466 (538 worldwide citation)

A method for delivering an isolated polynucleotide such as DNA or RNA, to the interior of a cell in a mammal comprising the injection of an isolated polynucleotide into a muscle of the mammal where the polynucleotide is taken up by the cells of the muscle and exerts a therapeutic effect on the mamma ...


3
Deborah A Eppstein, Philip L Felgner, Thomas R Gadek, Gordon H Jones, Richard B Roman: N[.omega.,(.omega.-1)-dialkyloxy]- and N-[.omega.,(.omega.-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor. Syntex, David A Lowin, Tom M Moran, January 30, 1990: US04897355 (361 worldwide citation)

This invention relates to compounds of the formula ##STR1## or an optical isomer thereof wherein R.sup.1 and R.sup.2 are the same or different and are an alkyl or alkenyl group of 6 to 24 carbon atoms; R.sup.3, R.sup.4 and R.sup.5 are the same or different and are alkyl of 1 to 8 carbon atoms, aryl, ...


4
Philip L Felgner, Raj Kumar, Channa Basava, Richard C Border, Jiin Yu Hwang Felgner: Cationic lipids for intracellular delivery of biologically active molecules. Vical, Knobbe Martens Olson & Bear, October 17, 1995: US05459127 (350 worldwide citation)

Disclosed are cationic lipids capable of facilitating transport of biologically active agents into cells, including the transfection of cells by therapeutic polynucleotides, the delivery of antiviral drugs, and the introduction of immunogenic peptides. The cationic lipids, comprising an ammonium gro ...


5
Philip L Felgner, Raj Kumar, Channa Basava, Richard C Border, Jiin Yu Hwang Felgner: Cationic lipids for intracellular delivery of biologically active molecules. Vical, Knobbe Martens Olson & Bear, November 23, 1993: US05264618 (300 worldwide citation)

Disclosed are cationic lipids capable of facilitating transport of biologically active agents into cells, including the transfection of cells by therapeutic polynucleotides, the delivery of antiviral drugs, and the introduction of immunogenic peptides. The cationic lipids, comprising an ammonium gro ...


6
Philip L Felgner, Jon Asher Wolff, Gary H Rhodes, Robert Wallace Malone, Dennis A Carson: Induction of a protective immune response in a mammal by injecting a DNA sequence. Vical Incorporated, Sterne Kesseler Goldstein & Fox P L L C, April 10, 2001: US06214804 (270 worldwide citation)

A method for delivering an isolated polynucleotide to the interior of a cell in a vertebrate, comprising the interstitial introduction of an isolated polynucleotide into a tissue of the vertebrate where the polynucleotide is taken up by the cells of the tissue and exerts a therapeutic effect on the ...


7
Philip L Felgner, Jon Asher Wolff, Gary H Rhodes, Robert Wallace Malone, Dennis A Carson: Generation of antibodies through lipid mediated DNA delivery. Wisconsin Alumni Research Foundation, Vical Incorporated, Knobbe Martens Olson & Bear, December 30, 1997: US05703055 (252 worldwide citation)

A method is disclosed for delivering an isolated polynucleotide to the interior of a cell in a vertebrate, comprising the interstitial introduction of an isolated polynucleotide into a tissue of the vertebrate where the polynucleotide is taken up by the cells of the tissue and exerts a therapeutic e ...


8
Jon A Wolff, David J Duke, Philip L Felgner: Expression of exogenous polynucleotide sequences cardiac muscle of a mammal. Vical Incorporated, Wisconsin Alumni Research Foundation, Knobbe Martens Olson & Bear, December 2, 1997: US05693622 (172 worldwide citation)

The present invention provides a method for delivering a pharmaceutical polypeptide to the interior of a cardiac cell of a vertebrate in vivo, comprising the step of introducing a preparation comprising a pharmaceutically acceptable injectable carrier and naked polynucleotide operatively coding for ...


9
Deborah A Eppstein, Philip L Felgner, Thomas R Gadek, Gordon H Jones, Richard B Roman: N-(.omega.,(.omega.-1)-dialkyloxy)- and N-(.omega.,(.omega.-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor. Syntex, David A Lowin, Tom M Moran, August 7, 1990: US04946787 (160 worldwide citation)

This invention relates to compounds of the formula ##STR1## or an optical isomer thereof wherein R.sup.1 and R.sup.2 are the same or different and are an alkyl or alkenyl group of 6 to 24 carbon atoms; R.sup.3, R.sup.4 and R.sup.5 are the same or different and are alkyl of 1 to 8 carbon atoms, aryl, ...


10
Deborah A Eppstein, Philip L Felgner, Thomas R Gadek, Gordon H Jones, Richard B Roman: N-(.omega., (.omega.-1)-dialkyloxy)- and N-(.omega., (.omega.-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor. Syntex, David A Lowin, Tom M Moran, May 4, 1993: US05208036 (131 worldwide citation)

This invention relates to compounds of the formula ##STR1## or an optical isomer thereof wherein R.sup.1 and R.sup.2 are the same or different and are an alkyl or alkenyl group of 6 to 24 carbon atoms; R.sup.3, R.sup.4 and R.sup.5 are the same or different and are alkyl of 1 to 8 carbon atoms, aryl, ...