1
Petersen Uwe Dr, Krebs Andreas Dr, Schenke Thomas Dr, Philipps Thomas Dr, Grohe Klaus Dr, Bremm Klaus Dieter Dr, Endermann Rainer Dr, Metzger Karl Georg Dr, Haller Ingo Dr: Quinolone- and naphthyridone carboxylic acid derivatives as antibacterial agents.. Bayer, July 14, 1993: EP0550903-A1 (46 worldwide citation)

Quinolone- and naphthyridone-carboxylic acid derivatives of the formula (I) in which B is a radical of the formulae in which Y is O or CH2 and R is C2-C5-oxoalkyl, CH2-CO-C6H5, CH2CH2CO2R', , -CH=CH-CO2R' or CH2CH2-CN, in which R' is hydrogen or C1-C3-alkyl, R is H, C1-C3-alkyl, 5-methyl-2-oxo-1,3-d ...


2
Petersen Uwe Dr, Schenke Thomas Dr, Krebs Andreas Dr, Grohe Klaus Dr, Schriewer Michael Dr, Haller Ingo Dr, Metzger Karl Georg Dr, Endermann Rainer Dr, Zeiler Hans Joachim Dr: 7-(1-pyrrolidinyl)-3-quinolone- and -naphthyridone-carboxylic-acid derivatives, method for their preparation and for substituted mono- and bi-cyclic pyrrolidine intermediates, and their antibacterial and feed additive compositions.. Bayer, January 17, 1990: EP0350733-A2 (43 worldwide citation)

Die Erfindung betrifft 7-(1-Pyrrolidinyl)-3-chinolon- und -naphthyridoncarbonsäure-Derivate der Formel (I) R für einen Rest der Struktur steht, worin R für H, Alkyl, Aryl, Acyl R für H, Alkyl, OH, OCH3, wobei R und R gemeinsam auch eine gegebenenfalls durch Methyl ein- oder zweifach substituierte Al ...


3
Grohe Klaus Dr, Petersen Uwe Dr, Zeiler Hans Joachim Dr, Metzger Karl Georg Dr: 7-amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinoline-carboxylic acid, processes for their preparation and antibacterial agents containing them.. Bayer, November 28, 1984: EP0126355-A1 (38 worldwide citation)

7-Amino-1-cyclopropyl-6,8-difluor-1,4-dihydro-4-oxo-3-chinolincarbonsäuren der Formel in der R und R die in der Beschreibung angegebene Bedeutung haben, zeichnen sich durch starke antibakterielle Wirkung aus und sollen als Wirkstoffe von Arzneimitteln verwendet werden.


4
Schriewer Michael Dr, Grohe Klaus Dr, Krebs Andreas Dr, Petersen Uwe Dr, Schenke Thomas Dr, Haller Ingo Dr, Metzger Karl Georg Dr, Endermann Rainer Dr, Zeiler Hans Joachim Dr: 5-alkylquinolinone carboxylic acids.. Bayer, October 10, 1990: EP0391132-A1 (26 worldwide citation)

The invention relates to novel quinolone- and naphthyridonecarboxylic acid derivatives of the formula (I) in which R1, R2, R3, R4 and A have the meaning given in the description and which carry an alkyl or a substituted alkyl radical in the 5-position, a process for their preparation and antibacteri ...


5
Petersen Uwe Dr, Grohe Klaus Dr, Zeiler Hans Joachim Dr, Metzger Karl Georg Dr: 7-amino-1-cyclopropyl-6,8-dihalo-1,4-dihydro-4-oxo-3-quinoline-carboxylic acids, process for their preparation and bactericidal agents containing them.. Bayer, January 15, 1986: EP0167763-A1 (23 worldwide citation)

1. 7-Amino-1-cyclopropyl-6,8-dialogeno-1,4-dihydro- 4-oxo-3-quinolinecarboxylic acids of the formula (I) see diagramm : EP0167763,P19,F1 in which X**1 and X**2 , which can be identical or different, represent chlorine or fluorine, but cannot both be fluorine, and R**1 and R**2 , together with the ni ...


6
Petersen Uwe Dr, Grohe Klaus Dr, Schriewer Michael Dr, Schenke Thomas Dr, Haller Ingo Dr, Metzger Karl Georg Dr, Endermann Rainer Dr, Zeiler Hans Joachim Dr: 5-substituted quinolone- and naphthyridone carboxylic acid derivatives.. Bayer, October 5, 1988: EP0284935-A1 (18 worldwide citation)

5-Substituted quinolone- and naphthyridonecarboxylic acid derivatives of the formula (I) in which X, Y, R, R and R have the meaning given in the description, processes for their preparation and antibacterial agents and food additives containing them.


7
Himmler Thomas Dr, Petersen Uwe Dr, Bremm Klaus Dieter Dr, Endermann Rainer Dr, Stegemann Michael Dr, Wetzstein Heinz Georg Dr: 5-vinyl- and 5-ethinyl-quinolinone- and -naphthyridone-carboxylic acids.. Bayer, September 13, 1995: EP0671391-A1 (17 worldwide citation)

Quinolone and naphthyridone derivs. of formula (I), and their hydrates, acid addn. salts, and alkali-, alkaline earth, silver and guanidinium salts, are new. R1 = 1-4C alkyl (opt. substd. by OH, halo or 1-3C alkoxy), 3-6C cycloalkyl (opt. substd. by halo or 1-3C alkyl), 2-4C alkenyl, 1-3C alkoxy, am ...


8
Petersen Uwe Dr, Krebs Andreas Dr, Schenke Thomas Dr, Kunisch Franz Dr, Philipps Thomas Dr, Grohe Klaus Dr, Bremm Klaus Dieter Dr, Endermann Rainer Dr, Metzger Karl Georg, Haller Ingo Dr, Zeiler Hans Joachim Dr: 7-isoindolinyl-quinolone and naphthyridonecarboxylic acid derivatives.. Bayer, December 30, 1992: EP0520240-A1 (17 worldwide citation)

The invention relates to novel quinolone- and -naphthyridonecarboxylic acid derivatives which are substituted in the 7-position by a partially hydrogenated isoindolinyl ring, to processes for their preparation, and to antibacterial agents and feed additives containing them.


9
Himmler Thomas Dr, Schriewer Michael Dr, Petersen Uwe Dr, Grohe Klaus Dr, Haller Ingo Dr, Metzger Karl Georg Dr, Endermann Rainer Dr, Zeiler Hans Joachim Dr: 7-substituted quinolone- and naphthyridinecarboxylic acid derivatives.. Bayer, November 29, 1989: EP0343398-A2 (17 worldwide citation)

The invention relates to 7-aryl- and 7-hetaryl-substituted quinolone- and naphthyridonecarboxylic acid derivatives of the general formula I in which R, R, X, X, A and Y have the meaning indicated in the description, process for their preparation and antibacterial agents containing them.


10
Schriewer Michael Dr, Petersen Uwe Dr, Grohe Klaus Dr, Krebs Andreas Dr: N-cyclopropyl anilines and their use in processes for the synthesis of 1-cyclopropyl-quinolone-carboxylic acids and their derivatives.. Bayer, September 13, 1989: EP0332033-A2 (16 worldwide citation)

N-Cyclopropylanilines of the formula (IV) in which R, X, X, X, A, Z and R have the meaning given in the description, which are suitable for the preparation of 4-quinolone- 3-carboxylic acids, and processes for the preparation of quinolone- carboxylic acid derivatives using N-cyclopropylanilines.