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Peter E Cross, Roger P Dickinson: Piperazinyl-substituted pyridine and imidazole anti-arrhythmic agents. Pfizer, Peter C Richardson, Paul H Ginsburg, Lawrence C Akers, February 21, 1989: US04806536 (46 worldwide citation)

A series of novel 4-substituted piperazinyl-pyridine and 4-substituted piperazinyl-imidazole compounds have been prepared, including their pharmaceutically acceptable salts, wherein the 4-substituent is a lower phenylalkyl group or a derivative thereof further substituted on the phenyl moiety by a s ...


3
Peter E Cross, Roger P Dickinson: Inhibition of thromboxane synthetase by 3-(1-Imidazolylalkyl) indoles. Pfizer, Francis X Murphy, Charles J Knuth, Peter C Richardson, June 16, 1981: US04273782 (39 worldwide citation)

Novel 3-(1-Imidazolylalkyl)indoles and the pharmaceutically acceptable acid addition salts thereof are disclosed. The novel compounds are useful in selectively inhibiting the action of the thromboxane synthetase enzyme without significantly inhibiting the action of the prostacycline synthetase or cy ...


4
Peter E Cross, Alexander R MacKenzie: Pyrrolidine derivatives. Pfizer, Peter C Richardson, Paul H Ginsburg, Seymore G Bekelnitzky, March 17, 1992: US05096890 (35 worldwide citation)

Compounds of the formula ##STR1## wherein R, Y and R.sup.1 are as defined in the specification. These compounds are muscarinic receptor antagonists which are selective for smooth muscle muscarinic sites over cardiac muscarinic sites, and are useful in the treatment of diseases associated with altere ...


5
Peter E Cross, Alexander R MacKenzie: Muscarinic receptor antagonists. Pfizer, Peter C Richardson, Paul H Ginsburg, Garth Butterfield, August 23, 1994: US05340831 (27 worldwide citation)

Muscarinic receptor antagonists of formula (I), and their pharmaceutically acceptable salts, wherein Y is --CH.sub.2 --, --(CH.sub.2).sub.2 --, --CH.sub.2 O--, --(CH.sub.2).sub.2 O-- or --CH.sub.2 S--; R is --CH or --CONH.sub.2 ; and R.sup.1 is a group of formula (a), where R.sup.2 and R.sup.3 are e ...


6
Peter E Cross, Roger P Dickinson: N-Benzyl-imidazoles as selective inhibitors of the thromboxane synthetase enzyme. Pfizer, Connolly and Hutz, May 15, 1984: US04448781 (25 worldwide citation)

The N-(substituted benzyl) imidazoles are selective enzyme inhibitors and thus are useful in the treatment of heart disease, circulatory and vascular problems.


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David Alker, Peter E Cross: Piperidine and pyrrolidine derivatives. Pfizer, Peter C Richardson, Paul H Ginsburg, Garth Butterfield, September 6, 1994: US05344835 (24 worldwide citation)

According to the invention there is provided a compound of formula (I): R.sup.1 --O(CH.sub.2).sub.m A(CH.sub.2).sub.n XR or a pharmaceutically acceptable salt thereof, wherein R.sup.1 is a group of formula (a or b) where Z is --(CH.sub.2).sub.2-, --CH.dbd.CH--, --CH.sub.2 --S-- or --CH.sub.2 --O--; ...


8
Peter E Cross, Alexander R MacKenzie: Pyrrolidine derivatives. Pfizer, Peter C Richardson, Paul H Ginsburg, Seymour G Bekelnitzky, August 3, 1993: US05233053 (24 worldwide citation)

Compounds of the formula ##STR1## wherein R, Y and R.sup.1 are as defined in the specification. These compounds are muscarinic receptor antagonists which are selective for smooth muscle muscarinic sites over cardiac muscarinic sites, and are useful in the treatment of diseases associated with altere ...


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Peter E Cross, Roger P Dickinson: Phenyl piperazine anti-arrhythmia agents. Pfizer, Peter C Richardson, Paul H Ginsburg, Robert F Sheyka, November 29, 1988: US04788196 (23 worldwide citation)

A series of pyridyl or imidazolyl substituted phenyl piperazines having utility as anti-arrhythmic agents is disclosed.


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Peter E Cross, Roger P Dickinson, Geoffrey N Thomas: Heterocyclic thromboxane synthetase inhibitors and pharmaceutical compositions containing them. Pfizer, Charles J Knuth, Albert E Frost, Peter C Richardson, October 18, 1983: US04410539 (23 worldwide citation)

Heterocyclic thromboxane synthetase inhibitors of the formula ##STR1## wherein R.sup.1, which is attached to the 2-, 3- or 4-position, is hydrogen, halogen, C.sub.1 -C.sub.4 alkyl, hydroxy or C.sub.1 -C.sub.4 alkoxy;