1
Peter C Simpson, James R Petisce, Victoria Carr Brendel, James H Brauker: Electrode systems for electrochemical sensors. DexCom, Knobbe Martens Olson & Bear, July 11, 2006: US07074307 (719 worldwide citation)

The present invention relates generally to systems and methods for improved electrochemical measurement of analytes. The preferred embodiments employ electrode systems including an analyte-measuring electrode for measuring the analyte or the product of an enzyme reaction with the analyte and an auxi ...


2
Peter C Simpson, Paul Goode, Mark A Tapsak, Victoria Carr Brendel: Electrochemical sensors including electrode systems with increased oxygen generation. DexCom, Knobbe Martens Olson & Bear, September 19, 2006: US07108778 (639 worldwide citation)

The present invention relates generally to systems and methods for increasing oxygen generation in electrochemical sensors in order to overcome the oxygen limitations. The preferred embodiments employ electrode systems with at least two electrodes in relatively close proximity to each other; wherein ...


3
Andrew Rasdal, James H Brauker, Paul V Neale, Peter C Simpson: Integrated receiver for continuous analyte sensor. Dexcom, Knobbe Martens Olson & Bear, April 14, 2009: US07519408 (541 worldwide citation)

A system is provided for monitoring glucose in a host, including a continuous glucose sensor that produces a data stream indicative of a host's glucose concentration and an integrated receiver that receives the data stream from the continuous glucose sensor and calibrates the data stream using a sin ...


4
James H Brauker, Mark A Tapsak, Sean T Saint, Apurv U Kamath, Paul V Neale, Peter C Simpson, Michael Robert Mensinger, Dubravka Markovic: Integrated delivery device for continuous glucose sensor. Dexcom, Knobbe Martens Olson and Bear, September 22, 2009: US07591801 (530 worldwide citation)

Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, and optionally a single point glucose monitor are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) ...


5
James Petisce, Mark A Tapsak, Peter C Simpson, Victoria Carr Brendel, James H Brauker: Oxygen enhancing membrane systems for implantable devices. DexCom, Knobbe Martens Olson & Bear, May 27, 2008: US07379765 (392 worldwide citation)

The present invention relates generally to systems and methods for increasing oxygen availability to implantable devices. The preferred embodiments provide a membrane system configured to provide protection of the device from the biological environment and/or a catalyst for enabling an enzymatic rea ...


6
Victoria Carr Brendel, Peter C Simpson, James H Brauker: Biointerface membrane with macro-and micro-architecture. DexCom, Knobbe Martens Olson & Bear, April 29, 2008: US07364592 (383 worldwide citation)

Disclosed herein are biointerface membranes including a macro-architecture and a micro-architecture co-continuous with and bonded to and/or located within at least a portion of the macro-architecture. The macro- and micro-architectures work together to manage and manipulate the high-level tissue org ...


7
Peter C Simpson, Mark Shults, Rathbun K Rhodes, Paul V Goode Jr, Arnold L Holmquist: Implantable analyte sensor. DexCom, Knobbe Martens Olson & Bear, February 2, 2010: US07657297 (375 worldwide citation)

An implantable analyte sensor including a sensing region for measuring the analyte and a non-sensing region for immobilizing the sensor body in the host. The sensor is implanted in a precisely dimensioned pocket to stabilize the analyte sensor in vivo and enable measurement of the concentration of t ...


8
Mark Brister, James R Petisce, Sean Saint, Kum Ming Woo, Victor Ha, John Nolting, Peter C Simpson, James Brauker: Transcutaneous analyte sensor. DexCom, Knobbe Martens Olson & Bear, May 11, 2010: US07713574 (337 worldwide citation)

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.


9
Apurv Ullas Kamath, Peter C Simpson, James H Brauker, Paul V Goode Jr: Calibration techniques for a continuous analyte sensor. DexCom, Knobbe Martens Olson & Bear, May 11, 2010: US07715893 (314 worldwide citation)

Disclosed herein are systems and methods for calibrating a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes one or more electrodes to measure an additional analyte. Such measurements may provide a baseline or sensitivity measurement for use in calibrating the ...


10
Richard A Mathies, Peter C Simpson, Stephen J Williams: Process for microfabrication of an integrated PCR-CE device and products produced by the same. Affymetrix, Pillsbury Winthrop, July 17, 2001: US06261431 (117 worldwide citation)

A fully integrated monolithic small volume PCR-CE device in glass, or the like materials, is fabricated using thin film metal heaters and thermocouples to thermally cycle sub-microliter PCR volumes. Successful amplification of a PCR fragment is demonstrated on a PCR-CE chip. The process utilizes a l ...