1
Nigel R Oakley, Ian H Coates, Peter C North, Alexander W Oxford: 5-HT.sub.3 receptor antagonists for the treatment of autism. Glaxo Group, Bacon & Thomas, July 6, 1993: US05225407 (42 worldwide citation)

The invention relates to the use of a compound which acts as an antagonist of 5-HT at 5-HT.sub.3 receptors in the treatment of autism or another disorder originating in childhood in which there is mental retardation.


2
Martin R Johnson, Peter C North: Indolyl compounds and their use in treatment of cephalic pain. Glaxo Group, Bacon & Thomas, December 12, 1995: US05475020 (17 worldwide citation)

The invention relates to indoles of general formula (I) ##STR1## wherein R.sub.0 represents a hydrogen atom or a C.sub.1-3 alkyl group; R.sub.1 represents a group R.sub.4 CONH--, R.sub.4 R.sub.5 NSO.sub.2 --, R.sub.4 SO.sub.2 NH-- or R.sub.4 R.sub.5 NCO-- (where R.sub.4 is a hydrogen atom or a C.sub ...


3
David E Bays, Ian H Coates, Alexander W Oxford, Peter C North: Lactam derivatives. Glaxo Group, Bacon & Thomas, March 5, 1991: US04997831 (16 worldwide citation)

The invention provides lactam derivatives of the general formula (I) ##STR1## wherein n represents 2 or 3; Im represents an imidazolyl group of the formula: ##STR2## wherein one of the groups represented by R.sup.1, R.sup.2 and R.sup.3 is a hydrogen atom or a C.sub.1-6 alkyl, C.sub.3-7 cycloalkyl, C ...


4
Ian H Coates, Alexander W Oxford, Peter C North, Barry J Price: Lactam derivatives. Glaxo Group, Bacon & Thomas, February 2, 1993: US05183820 (15 worldwide citation)

The invention provides potent and selective antagonists of 5-HT at 5-HT.sub.3 receptors which are tricyclic lactams of the formula (I) ##STR1## wherein Im represents an imidazolyl group of the formula: ##STR2## and R.sup.1 represents a hydrogen atom or a group selected from C.sub.1-6 alkyl, C.sub.3- ...


5
Ian H Coates, Alexander W Oxford, Peter C North, Thomas Miller, Anthony D Baxter, Kevin I Hammond: Lactam derivatives. Glaxo Group, Bacon & Thomas, May 7, 1991: US05013733 (15 worldwide citation)

The invention provides lactam derivatives of the general formula (I) ##STR1## wherein R.sup.1 represents a hydrogen atom or a group selected from C.sub.1-6 alkyl, C.sub.3-6 alkenyl, C.sub.3-10 alkynyl, C.sub.3-7 cycloalkyl, C.sub.3-7 cycloalkylC.sub.1-4 alkyl, phenyl, phenylC.sub.1-3 alkyl, phenylme ...


6
Peter C North, Alexander W Oxford, Ian H Coates, Paul J Beswick: Lactam derivatives. Glaxo Group, Bacon & Thomas, January 15, 1991: US04985422 (13 worldwide citation)

Compounds which are potent and selective antagonists of the effect of 5-HT.sub.3 receptors and are useful in the treatment of psychotic disorders, anxiety, and nausea and vomiting, of the general formula (I) ##STR1## wherein Im represents an imidazolyl group of the formula (a), (b) or (c): ##STR2## ...


7
Peter C North, Malcolm C Carter: Indoline derivatives, method of preparation and use. Glaxo Group, Bacon & Thomas, May 27, 1997: US05633276 (11 worldwide citation)

A compound of formula (I) ##STR1## wherein, R.sup.1 is hydrogen, halogen or C.sub.1-6 alkyl;


8
Alexander W Oxford, Peter C North: Ketone derivatives. Glaxo Group, Bacon & Thomas, May 28, 1991: US05019586 (10 worldwide citation)

The present invention provides ketones of the general formula (I): ##STR1## and physiologically acceptable salts and solvates thereof, wherein R.sup.1 and R.sup.2, which may be the same or different, each represents a hydrogen atom or a C.sub.1-6 alkyl group;


9
Ian H Coates, Peter C North, Alexander W Oxford: Tetrahydro-1H-pyrido[4,3-b]indol-1-one derivatives. Glaxo Group, Bacon & Thomas, November 1, 1994: US05360800 (8 worldwide citation)

The invention relates to tricyclic lactams of the general formula (I) ##STR1## wherein Im represents an imidazolyl group of the formula: ##STR2## and R.sup.1 represents a hydrogen atom or a group selected from C.sub.1-6 alkyl, C.sub.3-6 alkenyl, C.sub.3-10 alkynyl, C.sub.3-7 cycloalkyl, C.sub.3-7 cy ...


10
Alexander W Oxford, Peter C North, Martin R Johnson: Indole derivatives. Glaxo Group, Bacon & Thomas, March 19, 1991: US05001135 (5 worldwide citation)

Compounds are disclosed of formula (I) ##STR1## wherein R.sub.1 represents a C.sub.1-6 alkyl group;