1
Robert Karasiewicz, Carlo Nalin, Perry Rosen: Peg-interferon conjugates. Hoffmann La Roche, George M Gould, William H Epstein, Catherine R Roseman, January 17, 1995: US05382657 (204 worldwide citation)

Substituted PEG-interferon conjugates of formulae IA and IB where PEG is linked by means of activated linking reagents of formulae IIA, IIB, or IIB-1 to an amino group in the interferon, and activated linking reagents of formulae IIA, IIB, or IIB-1. The conjugates are not readily susceptible to in v ...


2
John Hakimi, Patricia Kilian, Perry Rosen: Polyethylene-protein conjugates. Hoffmann La Roche, George W Johnston, William H Epstein, Lewis J Kreisler, May 5, 1998: US05747646 (127 worldwide citation)

The present invention is a physiologically active, substantially non-immunogenic water soluble polyethylene glycol protein conjugate having the same utility as the protein which forms the conjugate, without having the same properties of producing an immunogenic response possessed by the protein whic ...


3
John Hakimi, Patricia Kilian, Perry Rosen: Polyethylene-protein conjugates. Hoffman La Roche, George W Johnston, William H Epstein, Lewis J Kreisler, November 10, 1998: US05834594 (120 worldwide citation)

The present invention is a physiologically active, substantially non-immunogenic water soluble polyethylene glycol protein conjugate having the same utility as the protein which forms the conjugate, without having the same properties of producing an immunogenic response possessed by the protein whic ...


4
John Hakimi, Patricia Kilian, Perry Rosen: Polyethylene-protein conjugates. Hoffmann La Roche, George W Johnston, William H Epstein, Briana C Buchholz, December 15, 1998: US05849860 (99 worldwide citation)

The present invention is a physiologically active, substantially non-immunogenic water soluble polyethylene glycol protein conjugate having the same utility as the protein which forms the conjugate, without having the same properties of producing an immunogenic response possessed by the protein whic ...


5
John Hakimi, Patricia Kilian, Perry Rosen: Polyethylene-protein conjugates. Hoffmann La Roche, George W Johnston, William H Epstein, Catherine R Smith, September 24, 1996: US05559213 (84 worldwide citation)

The present invention is a physiologically active, substantially non-immunogenic water soluble polyethylene glycol protein conjugate having the same utility as the protein which forms the conjugate, without having the same properties of producing an immunogenic response possessed by the protein whic ...


6
John Hakimi, Patricia Kilian, Perry Rosen: Polyethylene-protein conjugates. Hoffmann La Roche, George W Johnston, William H Epstein, Lewis J Kreisler, August 11, 1998: US05792834 (69 worldwide citation)

The present invention is a physiologically active, substantially non-immunogenic water soluble polyethylene glycol protein conjugate having the same utility as the protein which forms the conjugate, without having the same properties of producing an immunogenic response possessed by the protein whic ...


7
John Hakimi, Patricia Kilian, Perry Rosen: Polymer for making poly(ethylene glycol)-protein conjugates. Hoffmann La Roche, George M Gould, William H Epstein, Catherine R Smith, July 23, 1996: US05539063 (50 worldwide citation)

The present invention is a polymer which may be used to produce a physiologically active, substantially non-immunogenic water soluble polyethylene glycol protein conjugate having the same utility as the protein which forms the conjugate, without having the same properties of producing an immunogenic ...


8
John Hakini, Patricia Kilian, Perry Rosen: Polyethylene-protein conjugates. Hoffmann La Roche, George W Johnston, William H Epstein, Catherine R Smith, January 21, 1997: US05595732 (23 worldwide citation)

The present invention is a physiologically active, substantially non-immunogenic water soluble polyethylene glycol protein conjugate having the same utility as the protein which forms the conjugate, without having the same properties of producing an immunogenic response possessed by the protein whic ...


9
George W Holland, Perry Rosen, Hans Maag: 7-Fluoro-prostacyclin analogs. Hoffmann La Roche, Jon S Saxe, George M Gould, William H Epstein, December 10, 1985: US04558142 (22 worldwide citation)

The prostacyclins 7-fluoro-6,9-epoxy-16-substituted-15-hydroxyprost-[4 or 5,13]-dienoic acids and esters useful as anti-secretory agents, blood pressure lowering agents, anti-ulcerogenic agents, anti-hypertensive agents, bronchodilation agents and for combating gastro-hyperacidity and as anti-blood ...


10
Perry Rosen, Kwang Nho: Bifunctional polyethylene glycol derivatives. Sun Bio, May 15, 2007: US07217845 (17 worldwide citation)

The present invention provides novel heterobifunctional and monobifunctional polyethylene glycol derivatives for the pegylation of therapeutically active proteins. The heterobifunctional PEGs which bear two different functional groups as well as the monobifunctional PEGs which contain two similar fu ...