1
Jens Marcel Van Roey, Marie Pierre T M M G De Bethune, Paul Stoffels: Tibotec Pharmaceuticals, Woodcock Washburn, May 3, 2011: US07935710 (3 worldwide citation)

The present invention concerns the microbicidal activity of certain pyrimidine or triazine containing non-nucleoside reverse transcriptase inhibitors. The compounds of the present invention inhibit the systemic infection of a human being with HIV, in particular, the present compounds prevent sexual ...


2
Jérôme Emile Georges Guillemont, Paul Theodoor Agnes Stevens, Alex Herman Copmans, Jozef Peeters, Alfred Elisabeth Stappers, Roger Petrus Gerebern Vandecruys, Paul Stoffels: Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino] benzonitrile. Janssen Pharmaceutica, December 29, 2009: US07638522 (2 worldwide citation)

The present invention relates to a pharmaceutical composition comprising as active ingredient the hydrochloric acid salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethyl-phenyl]amino]-2-pyrimidinyl]amino]benzonitrile and to processes for their preparation.


3
Paul Stoffels: Combinations of a pyrimidine containing NNRTI with RT inhibitors. Janssen R & D Ireland, Kirk Baumeister, September 23, 2014: US08841310 (1 worldwide citation)

The present invention concerns combinations of a pyrimidine containing NNRTI with nucleoside reverse transcriptase inhibitors and/or nucleotide reverse transcriptase inhibitors useful for the treatment of HIV infected patients or for the prevention of HIV transmission or infection.


4
Jérôme Emile Georges Guillemont, Paul Theodoor Agnes Stevens, Alex Herman Copmans, Jozef Peeters, Alfred Elisabeth Stappers, Roger Petrus Gerebern Vandecruys, Paul Stoffels: Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile. Janssen Pharmaceutica, Rajiv S Shah, January 24, 2012: US08101629 (1 worldwide citation)

The present invention relates to a pharmaceutical composition comprising as active ingredient the hydrochloric acid salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethyl-phenyl]amino]-2-pyrimidinyl]amino]benzonitrile and to processes for their preparation.


5
Jérôme Emile Georges Guillemont, Paul Theodoor Agnes Stevens, Alex Herman Copmans, Jozef Peeters, Alfred Elisabeth Stappers, Roger Petrus Gerebern Vandecruys, Paul Stoffels: Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile. Janssen Pharmaceutica, Rajiv S Shah, June 7, 2011: US07956063 (1 worldwide citation)

The present invention relates to a pharmaceutical composition comprising as active ingredient the hydrochloric acid salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethyl-phenyl]amino]-2-pyrimidinyl]amino]benzonitrile and to processes for their preparation.


6
Kees Groen, Paul Stoffels: System and method for optimizing drug theraphy for the treatment of diseases. Philip S Johnson, Johnson & Johnson, February 5, 2004: US20040023211-A1

The present invention concerns the optimization of hiv-1 therapy using the combination of a bioanalytical method, population pharmacokinetic models and phenotypic resistance testing.


7
Paul Stoffels: Combinations Of A Pyrimidine Containing Nnrti With Rt Inhibitors. Tibotec Pharmaceuticals a corporation, Philip S Johnson, Johnson & Johnson, August 21, 2008: US20080200435-A1

The present invention concerns combinations of a pyrimidine containing NNRTI with nucleoside reverse transcriptase inhibitors and/or nucleotide reverse transcriptase inhibitors useful for the treatment of HIV infected patients or for the prevention of HIV transmission or infection.


8
Ronald Van Der Geest, Paul Stoffels, Cornelis Groen, Jochmans Dirk Edward Desire: Combination of cytochome p450 dependent protease inhibitors. Philip S Johnson, Johnson & Johnson, June 2, 2005: US20050119338-A1

The present invention relates to a method for improving the pharmacokinetics of hexahydrofuro[2,3-b]furanyl containing HIV protease inhibitors comprising administering to a human in need thereof a combination of a therapeutically effective amount of a hexahydrofuro[2,3-b]furanyl containing HIV prote ...


9
Kees Groen, Paul Stoffels: System and method for optimizing drug therapy for the treatment of diseases. Johnson & Johnson, January 10, 2008: US20080008991-A1

The present invention concerns the optimization of hiv-1 therapy using the combination of a bioanalytical method, population pharmacokinetic models and phenotypic resistance testing.


10
Jens Marcel Van Roey, Marie Pierre TMMG De Bethune, Paul Stoffels: Tibotec Pharmaceuticals, Woodcock Washburn, July 27, 2006: US20060166943-A1

A present invention concerns the microbicidal activity of certain pyrimidine or triazine containing non-nucleoside reverse transcriptase inhibitors. The compounds of the present invention inhibit the systemic infection of a human being with HIV, in particular, the present compounds prevent sexual HI ...