1
Keith E Dionne, Dwaine F Emerich, Diane Hoffman, Paul R Sanberg, Lisa Christenson, Orion D Hegre, David W Scharp, Paul E Lacy, Patrick Aebischer, Alfred V Vasconcellos, Michael J Lysaght, Frank T Gentile: Implantable biocompatable immunoisolatory vehicle for delivery of selected therapeutic products. Brown University Research Foundation, Brown University, Ivor R Elrifi, John Prince, Mintz Levin Cohn Ferris Glovsky and Popeo P C, July 4, 2000: US06083523 (288 worldwide citation)

An immunoisolatory vehicle for the implantation into an individual of cells which produce a needed product or provide a needed metabolic function. The vehicle is comprised of a core region containing isolated cells and materials sufficient to maintain the cells, and a permselective, biocompatible, p ...


2
Patrick Aebischer, Moses Goddard, John G Moldauer, Paul J Mulhauser, Anne M Rathbun, Paul R Sanberg, Alfred V Vasconcellos, Nicholas F Warner: Implantable therapy systems and methods. Brown University Research Foundation, Ivor R Elrifi, Barbara A Ruskin, Fish & Neave, January 30, 1996: US05487739 (165 worldwide citation)

Implantable therapy systems are disclosed for the local and controlled delivery of a biologically active factor to the brain, spinal cord and other target regions of a subject suffering from a debilitating condition. The method of the invention involves surgically exposing an insertion site, general ...


3
Keith E Dionne, Dwaine F Emerich, Diane Hoffman, Paul R Sanberg, Lisa Christenson, Orion D Hegre, David W Scharp, Paul E Lacy, Patrick Aebischer, Alfred V Vasconcellos, Michael J Lysaght, Frank T Gentile: Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products. Brown University Research Foundation, Ivor R Mintz Levin Elrifi, September 1, 1998: US05800828 (88 worldwide citation)

Immunoisolatory vehicles having a core and a surrounding jacket are disclosed, the core having a volume in excess of 1 .mu.l and at least about 10.sup.4 living cells capable of secreting a biologically active product or of providing a biological function to a patient, the cells dispersed in a biocom ...


4
Keith E Dionne, Dwaine F Emerich, Diane Hoffman, Paul R Sanberg, Lisa Christenson, Orion D Hegre, David W Scharp, Paul E Lacy, Patrick Aebischer, Alfred V Vasooncellos, Michael J Lysaght, Frank T Gentile: Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products. Brown University Research Foundation, Ivor R Elrifi, Mintz Levin, August 25, 1998: US05798113 (68 worldwide citation)

A method of providing a biologically active molecule or metabolic or immunologic function to a patient, comprising implanting into the body of the patient at least one immunoisolatory vehicle comprising a core comprising a volume in excess of 1 .mu.l and at least about 10.sup.4 living cells disperse ...


5
Keith E Dionne, Dwaine F Emerich, Diane Hoffman, Paul R Sanberg, Lisa Christenson, Orion D Hegre, David W Scharp, Paul E Lacy, Patrick Aebischer, Alfred V Vasconcellos, Michael J Lysaght, Frank T Gentile: Methods for treatment or prevention of neurodegenerative conditions using immunoisolatory implantable vehicles with a biocompatible jacket and a biocompatible matrix core. Brown University Research Foundation, Ivor R Mintz Levin Ekrufu, February 16, 1999: US05871767 (63 worldwide citation)

A method for treatment of a neurodegenerative condition in a patient comprising implanting in the patient at least one immunoisolatory vehicle comprising a corc comprising a volume of at least 1 .mu.l and at least 10.sup.4 living cells which secrete at least one biologically active product, said cel ...


6
Patrick Aebischer, Moses Goddard, John G Moldauer, Paul J Mulhauser, Anne M Rathbun, Paul R Sanberg, Alfred V Vasconcellos, Nicholas F Warner: Implantable therapy systems and methods. Brown University Research Foundation, Ivor R Elrifi, John T Prince, Mintz Levin Cohn Ferris Glovsky and Popeo P C, January 30, 2001: US06179826 (52 worldwide citation)

Implantable therapy systems are disclosed for the local and controlled delivery of a biologically active factor to the brain, spinal cord and other target regions of a subject suffering from a dibilatating condition. The method of the invention involves surgically exposing an insertion site, general ...


7
Keith E Dionne, Dwaine F Emerich, Diane Hoffman, Paul R Sanberg, Lisa Christenson, Orion D Hegre, David W Scharp, Paul E Lacy, Patrick Aebischer, Alfred V Vasoohcellos, Michael J Lysaght, Frank T Gentile: Methods for making immunoisolatary implantable vehicles with a biocompatible jacket and a biocompatible matrix core. Brown University Research Foundation, Ivor R Mitz Levin Elrifi, February 23, 1999: US05874099 (32 worldwide citation)

A method of forming an implantable and retrievable immunoisolatory vehicles is disclosed, the method comprising the steps of first forming a core comprising a volume of at least 1 .mu.l and at least 10.sup.4 cells capable of providing a biologically active product or metabolic or immunologic functio ...


8
Keith E Dionne, Dwaine F Emerich, Diane Hoffman, Paul R Sanberg, Lisa Christenson, Orion D Hegre, David W Sharp, Paul E Lacy, Patrick Aebischer, Alfred V Vasconcellos, Michael J Lysaght, Frank T Gentile: Methods for making immunoisolatory implantable vehicles with a biocompatiable jacket and a biocompatible matrix core. Brown University Research Foundation, Ivor Elrifi Mintz Levin, November 10, 1998: US05834001 (30 worldwide citation)

A method of forming an implantable and retrievable immunoisolatory vehicle is disclosed, the method comprising the steps of first forming a jacket of biocompatible thermoplastic or hydrogel, and then loading the jacket with a core comprising a volume of at least 1 .mu.l and at least 10.sup.4 cells c ...


9
Keith E Dionne, Dwaine F Emerich, Diane Hoffman, Paul R Sanberg, Lisa Christenson, Orion D Hegre, David W Scharp, Paul E Lacy, Patrick Aebischer, Alfred V Vasconcellos, Michael J Lysaght, Frank T Gentile: Methods for coextruding immunoisolatory implantable vehicles with a biocompatible jacket and a biocompatible matrix core. Brown University Research Foundation, Ivor R Mintz Levin Elrifi, September 1, 1998: US05800829 (28 worldwide citation)

A method of making an immunoisolatory vehicle comprised of a core comprising living cells dispersed in a biocompatible matrix is disclosed, the cells being capable of secreting a biologically active product or of providing a metabolic or immunologic function to an individual, and an external jacket ...


10
Paul R Sanberg, Roland D Shytle, Archie A Silver: Nicotine antagonists for nicotine-responsive neuropsychiatric disorders. University of South Florida, Barbara J Luther, March 7, 2000: US06034079 (27 worldwide citation)

Nicotine-responsive neuropsychiatric disorders can be treated by administering a nicotine antagonist, particularly mecamylamine. Combination therapy of mecamylamine with a neuroleptic drug also is disclosed. The neuropsychiatric disorders include Tourette's syndrome, schizophrenia, depression, bipol ...