1
Paul R Meers, Charles Pak, Shaukat Ali, Andrew Janoff, J Craig Franklin, Ravi K Erukulla, Donna Cabral Lilly: Peptide-lipid conjugates. The Liposome Company, Rosanne Goodman, July 11, 2000: US06087325 (52 worldwide citation)

Peptide-lipid conjugates are incorporated into liposomes so as to selectively destabilize the liposomes in the vicinity of target peptidase-secreting cells, and hence, to deliver the liposomes to the vicinity of the target cells, or directly into the cells. The liposomes can thus be used to treat ma ...


2
Paul R Meers, Charles Pak, Shaukat Ali, Andrew Janoff, J Craig Franklin, Ravi K Erukulla, Donna Cabral Lilly, Patrick L Ahl: Peptide-lipid conjugates, liposomes and lipsomal drug delivery. Elan PharmaceuticalsTechnologies, Burns Doane Swecker & Mathis L, January 15, 2002: US06339069 (41 worldwide citation)

Peptide-lipid conjugates are incorporated into liposomes so as to selectively destabilize the liposomes in the vicinity of target peptidase-secreting cells, and hence, to deliver the liposomes to the vicinity of the target cells, or directly into the cells. The liposomes can thus be used to treat ma ...


3
Paul R Meers, Tong Shangguan, Shaukat Ali, Andrew Janoff, Charles Pak: N-acyl phosphatidylethanolamine-mediated liposomal drug delivery. The Liposome Company, Rosanne Goodman, September 25, 2001: US06294191 (22 worldwide citation)

This invention provides liposomes containing one or more N-acylated phosphatidylethanolamines, such liposomes being useful for localizing the delivery of bioactive agents to cells.


4
Paul R Meers, Tong Shangguan, Shaukat Ali, Andrew Janoff, Charles Pak: N-acyl phosphatidylethanolamine-mediated liposomal drug delivery. The Liposome Company, Rosanne Goodman, September 19, 2000: US06120797 (17 worldwide citation)

This invention provides liposomes containing one or more N-acylated phosphatidylethanolamines, such liposomes being useful for localizing the delivery of bioactive agents to cells.


5
Paul R Meers, Tong Shangguan, Donna Cabral Lilly, Patrick Ahl, Ravi Erukulla, Andrew Janoff: Modular targeted liposomal delivery system. Transave, Foley Hoag, June 13, 2006: US07060291 (12 worldwide citation)

A liposome including a fusogenic liposome, a linking moiety and a targeting moiety. The fusogenic liposome is a lipid bilayer encapsulating contents. The linking moiety is electrostatically bound to the lipid bilayer, and the targeting moiety is covalently bound to the linking moiety. The liposome m ...


6
Paul R Meers, Charles Pak, Shaukat Ali, Andrew Janoff, J Craig Franklin, Ravi K Erukulla, Donna Cabral Lilly: Liposomal peptide-lipid conjugates and delivery using same. The Liposome Company, Rosanne Goodman, November 7, 2000: US06143716 (8 worldwide citation)

Peptide-lipid conjugates are incorporated into liposomes so as to selectively destabilize the liposomes in the vicinity of target peptidase-secreting cells, and hence, to deliver the liposomes to the vicinity of the target cells, or directly into the cells. The liposomes can thus be used to treat ma ...


7
Paul R Meers, Tong Shangguan, Donna Cabral Lilly, Patrick Ahl, Andrew S Janoff: Encapsulation of bioactive complexes in liposomes. Transave, Foley Hoag, February 17, 2009: US07491409 (4 worldwide citation)

This invention provides a method to prepare liposome-encapsulated bioactive agents such as nucleic acids, comprising complexation of the bioactive agents in reverse micelles prior to forming liposomes, as well as methods of using the liposomes so formed and formulations to deliver nucleic acids to c ...


8
Walter R Perkins, Vladimir Malinin, Paul R Meers: Formulations of DNase and Methods of Use Thereof. Foley Hoag, Patent Group World Trade Center West, June 5, 2008: US20080131497-A1

Compositions comprising DNase encapsulated in a liposome are provided. Additionally, provided are compositions comprising a free enzyme and empty liposomes, compositions comprising a free enzyme and an antiinfective encapsulated in a liposome, compositions comprising a free enzyme, a free-antiinfect ...


9
Shangguan Tong, Xingong Li, Paul R Meers, Walter R Perkins: Efficient nucleic acid encapsulation into medium sized liposomes. Buchanan Ingersoll PC, March 16, 2006: US20060058249-A1

A method for preparing liposomes containing at least one nucleic acid encapsulated therein comprising the following steps: (A) mixing a gel or a liquid containing gel particles with aqueous medium Z1 to directly form the liposomes containing the at least one nucleic acid encapsulated therein; (B)(i) ...


10
Paul R Meers, Tong Shangguan, Donna Cabral Lilly, Patrick Ahl, Ravi Erukulla, Andrew Janoff: Modular targeted liposomal delivery system. Transave, Foley Hoag, Patent Group World Trade Center West, August 3, 2006: US20060172003-A1

A liposome including a fusogenic liposome, a linking moiety and a targeting moiety. The fusogenic liposome is a lipid bilayer encapsulating contents. The linking moiety is electrostatically bound to the lipid bilayer, and the targeting moiety is covalently bound to the linking moiety. The liposome m ...