1
Sanjay Tyagi, Fred R Kramer, Paul M Lizardi: Detectably labeled dual conformation oligonucleotide probes, assays and kits. The Public Health Research Institute of the City of New York, Fish & Richardson P C, July 20, 1999: US05925517 (524 worldwide citation)

Unimolecular and bimolecular hybridization probes for the detection of nucleic acid target sequences comprise a target complement sequence, an affinity pair holding the probe in a closed conformation in the absence of target sequence, and either a label pair that interacts when the probe is in the c ...


2
Paul M Lizardi: Rolling circle replication reporter systems. Yale University, Arnall Golden & Gregory, December 29, 1998: US05854033 (442 worldwide citation)

Disclosed are compositions and a method for of amplifying nucleic acid sequences useful for detecting the presence of molecules of interest. The method is useful for detecting specific nucleic acids in a sample with high specificity and sensitivity. The method also has an inherently low level of bac ...


3
Paul M Lizardi, Fred R Kramer, Sanjay Tyagi, Cesar E Guerra, Hilda M L Buyoli: Nucleic acid process containing improved molecular switch. The Public Health Research Institute, The Salk Instiute for Biological Studies, Davis Hoxie Faithfull and Hapgood, June 2, 1992: US05118801 (223 worldwide citation)

A probe for the detection of a nucleic acid target sequence containing a molecular switch comprising three essential elements: a probe sequence of 20-60 nucleotides surrounded by switch sequences of 10-40 nucleotides which are complementary to each other, wherein the state of the switch is useful fo ...


4
Paul M Lizardi, Michael Caplan: Unimolecular segment amplification and sequencing. Yale University, Arnall Golden & Gregory, November 7, 2000: US06143495 (179 worldwide citation)

Disclosed are compositions and a method for amplification of and multiplex detection of molecules of interest involving rolling circle replication. The method is useful for simultaneously detecting multiple specific nucleic acids in a sample with high specificity and sensitivity. The method also has ...


5
Paul M Lizardi: Multiple displacement amplification. Yale University, Arnall Golden & Gregory, September 26, 2000: US06124120 (156 worldwide citation)

Disclosed are compositions and a method for amplification of nucleic acid sequences of interest. The method is based on stand displacement replication of the nucleic acid sequences of interest by multiple primers. In one preferred form of the method, referred to as multiple strand displacement ampli ...


6
Paul M Lizardi, Fred R Kramer, Sanjay Tyagi, Cesar E Guerra, Hilda M L Buyoli, Barbara C Chu, Gerald F Joyce, Leslie E Orgel: Assays and kits incorporating nucleic acid probes containing improved molecular switch. Public Health Research Institute of the City of New York, The Salk Institute for Biological Studies, Davis Hoxie Faithfull & Hapgood, May 17, 1994: US05312728 (148 worldwide citation)

A probe for the detection of a nucleic acid target sequence containing a molecular switch comprising three essential elements: a probe sequence of 20-60 nucleotides surrounded by switch sequences of 10-40 nucleotides which are complementary to each other, wherein the state of the switch is useful fo ...


7
Sanjay Tyagi, Fred R Kramer, Paul M Lizardi: Detectably labeled, dual conformation oligonucleotide probes, assays and kits. The Public Health Research Institute of the City of New York, Fish & Richardson P C, August 15, 2000: US06103476 (143 worldwide citation)

Unimolecular and bimolecular hybridization probes for the detection of nucleic acid target sequences comprise a target complement sequence, an affinity pair holding the probe in a closed conformation in the absence of target sequence, and either a label pair that interacts when the probe is in the c ...


8
Paul M Lizardi: Multiple displacement amplification. Yale University, Needle & Rosenberg P C, August 28, 2001: US06280949 (119 worldwide citation)

Disclosed are compositions and a method for amplification of nucleic acid sequences of interest. The method is based on stand displacement replication of the nucleic acid sequences of interest by multiple primers. In one preferred form of the method, referred to as multiple strand displacement ampli ...


9
Paul M Lizardi, Xiaohua Huang: Single molecule analysis target-mediated ligation of bipartite primers. Yale University, Needle & Rosenberg P C, November 13, 2001: US06316229 (116 worldwide citation)

Disclosed are compositions and a method for detecting single nucleic acid molecules using rolling circle amplification (RCA) of single-stranded circular templates, referred to as amplification target circles, primed by immobilized primers. In one form of the method, referred to as a bipartite primer ...


10
Paul M Lizardi: Rolling circle replication reporter systems. Yale University, Arnall Golden & Gregory, April 3, 2001: US06210884 (109 worldwide citation)

Disclosed are compositions and a method for of amplifying nucleic acid sequences useful for detecting the presence of molecules of interest. The method is useful for detecting specific nucleic acids in a sample with high specificity and sensitivity. The method also has an inherently low level of bac ...