1
Jian Chen, R Glenn Hammonds, Paul J Godowski, Melanie R Mark, Jennie P Mather, Ronghao Li: Mer receptor activation by gas6. Genentech, Mark T Kresnak, Flehr Hohbach Test Albritton & Herbert L, January 2, 2001: US06169070 (76 worldwide citation)

The translation product of the growth arrest-specific gene 6 (gas6) has been identified as an activator of the Mer receptor protein tyrosine kinase. The invention accordingly provides methods of activating Mer receptor in cells expressing it by exposing them to exogenous gas6 polypeptides. Also prov ...


2
Audrey Goddard, Paul J Godowski, Austin L Gurney, Margaret Ann Roy, William I Wood: Secreted and transmembrane polypeptides and nucleic acids encoding the same. Genentech, Elizabeth M Barnes, Mark T Kresnak, Heller Ehrman White & McAuliffe, July 12, 2005: US06916648 (47 worldwide citation)

The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to het ...


3
Paul J Godowski, Natalie A Lokker, Melanie R Mark: Single-chain hepatocyte growth factor variants. Genentech, Ginger R Dreger, May 31, 1994: US05316921 (41 worldwide citation)

The invention concerns hepatocyte growth factor (HGF) variants that are resistant to proteolytic cleavage by enzymes capable of in vivo conversion of HGF into its two-chain form. The single-chain HGF variants, which preferably have an amino acid alteration at or adjacent to any of amino acid positio ...


4
Paul J Godowski, Austin L Gurney: Tie ligand homologues. Genetech, Mark T Kresnak, February 29, 2000: US06030831 (34 worldwide citation)

The present invention concerns isolated nucleic acid molecules encoding the novel TIE ligands NL2, NL3 and FLS139, the proteins encoded by such nucleic acid molecules, as well as methods and means for making and using such nucleic acid and protein molecules.


5
Paul J Godowski, Melanie R Mark, Michael D Sadick, David L Shelton, Wai Lee Tan Wong: Kinase receptor activation assay. Genentech, Wendy M Lee, June 16, 1998: US05766863 (32 worldwide citation)

An assay for measuring activation (i.e., autophosphorylation) of a tyrosine kinase receptor of interest is disclosed.


6
Paul J Godowski, Natalie A Lokker, Melanie R Mark: Hepatocyte growth factor variants. Genentech, Diane L Marschang, August 20, 1996: US05547856 (28 worldwide citation)

The invention concerns hepatocyte growth factor (HGF) amino acid sequence variants. The preferred variants are resistant to proteolytic cleavage by enzymes capable of in vivo conversion of HGF into its two-chain form and/or contain a mutation within the protease domain of HGF.


7
Avi Ashkenazi, David Botstein, Luc Desnoyers, Dan L Eaton, Napoleone Ferrara, Ellen Filvaroff, Sherman Fong, Wei Qiang Gao, Hanspeter Gerber, Mary E Gerritsen, Audrey Goddard, Paul J Godowski, J Christopher Grimaldi, Austin L Gurney, Kenneth J Hillan, Ivar J Kljavin, Jennie P Mather, James Pan, Nicholas F Paoni, Margaret Ann Roy, Timothy A Stewart, Daniel Tumas, P Mickey Williams, William I Wood: Secreted and transmembrane polypeptides and nucleic acids encoding the same. Genentech, Elizabeth M Barnes, Mark T Kresnak, Ginger R Greger Esq, October 21, 2003: US06635468 (27 worldwide citation)

The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to het ...


8
Paul J Godowski, Melanie R Mark, Michael D Sadick, David L Shelton, Wai Lee Tan Wong: Kinase receptor activation assay. Genentech Incorporated, Wendy M Lee, April 6, 1999: US05891650 (25 worldwide citation)

An assay for measuring activation (i.e., autophosphorylation) of a tyrosine kinase receptor of interest is disclosed.


9
David Botstein, Audrey Goddard, Paul J Godowski, Austin L Gurney, Margaret Ann Roy, William I Wood: Secreted and transmembrane polypeptides and nucleic acids encoding the same. Genetech, Mark T Kresnak, Elizabeth M Barnes, Ginger R Dreger Esq, July 5, 2005: US06913919 (24 worldwide citation)

The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to het ...


10
Paul J Godowski, Natalie A Lokker, Melanie R Mark: Hepatocyte growth factor protease domain variants. Genentech, Ginger R Dreger, July 12, 1994: US05328837 (22 worldwide citation)

The invention concerns hepatocyte growth factor (HGF) variants that compise an amino acid alteration at a site within the protease domain of HGF and retaining substantially full receptor binding affinity of the corresponding wild-type HGF.



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