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G Richard Cathcart, Thomas Brennan Marquez, John A Bridgham, George S Golda, Harry A Guiremand, Marianne Hane, Louis B Hoff, Eric Lachenmeier, Melvyn N Kronick, Douglas H Keith, Paul E Mayrand, Michael L Metzker, William J Mordan, Lincoln J McBride, John Shigeura, Chen Hanson Ting, Norman M Whiteley: Automated molecular biology laboratory. Perkin Elmer Applied Biosystems Division, Donald R Boys, Joseph H Smith, August 22, 1995: US05443791 (318 worldwide citation)

A liquid-handling instrument has a worksurface with registration for modular stations to support containers of liquid, pipette apparatus with a pipette tip coupled to a sensing circuit, a robotic translation system for moving the pipette tip, and a control system with an iconic user interface for pr ...


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Paul E Mayrand: Methods for combined PCR amplification and hybridization probing using doubly labeled fluorescent probes. The Perkin Elmer Corporation, Paul D Grossman, November 25, 1997: US05691146 (89 worldwide citation)

An oligonucleotide probe is disclosed, the probe including an oligonucleotide, a fluorescer molecule attached to a first end of the oligonucleotide and a quencher molecule attached to the opposite end of the oligonucleotide. The probe is rendered impervious to digestion by the 5'.fwdarw.3' exonuclea ...


3
Paul E Mayrand: Methods and reagents for combined PCR amplification and hybridization probing. PE Corporation, Paul D Grossman, November 26, 2002: US06485903 (12 worldwide citation)

An oligonucleotide probe is disclosed, the probe including an oligonucleotide, a fluorescer molecule attached to a first end of the oligonucleotide and a quencher molecule attached to the opposite end of the oligonucleotide. The probe is rendered impervious to digestion by the 5′→3′ exonuclease acti ...


4
Paul E Mayrand: Method and reagents for combined PCR amplification and hybridization probing. The Perkin Elmer Corporation, Paul D Grossman, May 28, 2002: US06395518 (4 worldwide citation)

An oligonucleotide probe is disclosed, the probe including an oligonucleotide, a fluorescer molecule attached to a first end of the oligonucleotide and a quencher molecule attached to the opposite end of the oligonucleotide. The probe is rendered impervious to digestion by the 5′→3′ exonuclease acti ...


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Paul E Mayrand: Methods and reagents for combined PCR amplification. Applied Biosystems, Scott R Bortner, Andrew K Finn, Applied Biosystems, August 19, 2008: US07413708 (3 worldwide citation)

An oligonucleotide probe is disclosed, the probe including an oligonucleotide, a fluorescer molecule attached to a first end of the oligonucleotide and a quencher molecule attached to the opposite end of the oligonucleotide. The probe is rendered impervious to digestion by the 5′→3′ exonuclease acti ...


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Paul E Mayrand: Methods and reagents for combined PCR amplification and hybridization probing. Applera Corporation, Vincent M Powers, July 10, 2007: US07241596 (2 worldwide citation)

An oligonucleotide probe is disclosed, the probe including an oligonucleotide, a fluorescer molecule attached to a first end of the oligonucleotide and a quencher molecule attached to the opposite end of the oligonucleotide. The probe is rendered impervious to digestion by the 5′→3′ exonuclease acti ...


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Paul E Mayrand: Methods and reagents for combined PCR amplification. Life Technologies Corporation, December 7, 2010: US07847076 (1 worldwide citation)

An oligonucleotide probe is disclosed, the probe including an oligonucleotide, a fluorescer molecule attached to a first end of the oligonucleotide and a quencher molecule attached to the opposite end of the oligonucleotide. The probe is rendered impervious to digestion by the 5′→3′ exonuclease acti ...


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Paul E Mayrand: Methods and reagents for combined PCR amplification and hybridization probing. PE Corporation, Mila Kasan Patent Dept, Applied Biosystems, November 20, 2003: US20030215826-A1

An oligonucleotide probe is disclosed, the probe including an oligonucleotide, a fluorescer molecule attached to a first end of the oligonucleotide and a quencher molecule attached to the opposite end of the oligonucleotide. The probe is rendered impervious to digestion by the 5→3 exonuclease activi ...


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Paul E Mayrand: Methods and Reagents for Combined PCR Amplification. Applera Corporation, Mila Kasan Patent Dept, Applied Biosystems, February 28, 2008: US20080050742-A1

An oligonucleotide probe is disclosed, the probe including an oligonucleotide, a fluorescer molecule attached to a first end of the oligonucleotide and a quencher molecule attached to the opposite end of the oligonucleotide. The probe is rendered impervious to digestion by the 5′→3′ exonuclease acti ...


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Paul E Mayrand: Methods and Reagents for Combined PCR Amplification. Life Technologies Corporation, November 10, 2011: US20110275071-A1

An oligonucleotide probe is disclosed, the probe including an oligonucleotide, a fluorescer molecule attached to a first end of the oligonucleotide and a quencher molecule attached to the opposite end of the oligonucleotide. The probe is rendered impervious to digestion by the 5′→3′ exonuclease acti ...