1
Mircea C Popescu, Paul A Tremblay, Andrew S Janoff, Marc J Ostro, Elaine Chan, Alan Weiner: Pharmacological agent-lipid solution preparation. The Liposome Company, Allen Bloom, Ilene Janofsky, October 13, 1992: US05154930 (72 worldwide citation)

A pharmacological agent-lipid solution preparation comprising a lipophilic pharmacological agent, a desalted charged lipid and an aqueous-miscible lipid solvent such that upon introduction into an aqueous medium a suspension of lipid aggregates associated with the pharmacological agent are formed, a ...


2
Lois E Bolcsak, Lawrence Boni, Mircea C Popescu, Paul A Tremblay: Steroidal liposomes exhibiting enhanced stability. The Liposome Company, Allen Bloom, Ronald G Ort, March 31, 1992: US05100662 (68 worldwide citation)

The present invention relates to novel liposomes and liposome-like structures (vesicles) comprising an amount of a derivatized sterol either alone or in combination with additional liposome-forming lipids.


3
Andrew S Janoff, Mircea C Popescu, Carl R Alving, Michael W Fountain, Robert P Lenk, Marc J Ostro, Paul A Tremblay, Alan L Weiner: Drug preparations of reduced toxicity. The Liposome Company, Allen Bloom, Catherine L Kurtz, October 22, 1991: US05059591 (49 worldwide citation)

Preparations of drugs in admixture with certain ligands are described which, when administered to animals or humans, are less toxic than conventional drug preparations. Although the toxicity of the drug-ligand preparations described is greatly reduced, the drug retains pharmacological activity.


4
Andrew S Janoff, Mircea C Popescu, Alan L Weiner, Lois E Bolscak, Paul A Tremblay, Christine E Swenson: Steroidal liposomes. The Liposome Company, Allen Bloom, Thomas M Saunders, January 2, 1990: US04891208 (40 worldwide citation)

Steroidal liposomes comprising a bioactive agent and method for their administration are disclosed, the bilayers of said steroidal liposomes comprising a salt form of a carboxylic acid derivative of a sterol, a salt form of a polycarboxylic acid derivative of a sterol, a salt form of a hydroxy carbo ...


5
Paul A Tremblay, John J Kearns: Process for purification of phospholipids. The Liposome Company, Pennie & Edmonds, December 22, 1987: US04714571 (35 worldwide citation)

A process for the separation and purification of individual phospholipids, especially phosphatidylcholine or lecithin and phosphatidylethanolamine, from mixtures containing members of the sub-class of phosphatides, incorporating methods of solvent extraction appropriate to the scale of the sample an ...


6
Andrew S Janoff, Carl R Alving, Michael W Fountain, Robert P Lenk, Marc J Ostro, Mircea C Popescu, Paul A Tremblay, Alan L Weiner: Drug preparations of reduced toxicity. The Liposome Company, Allen Bloom, Thomas M Saunders, January 30, 1990: US04897384 (34 worldwide citation)

Preparations of drugs in admixture with certain ligands are described which, when administered to animals or humans, are less toxic than conventional drug preparations. Although the toxicity of the drug-ligand preparations described is greatly reduced, the drug retains pharmacological activity.


7
Andrew S Janoff, Lois E Bolcsak, Alan L Weiner, Paul A Tremblay, Michael V W Bergamini, Robert L Suddith: Composition using salt form of organic acid derivative of alpha-tocopheral. The Liposome Company, Allen Bloom, Catherine L Kurtz, August 29, 1989: US04861580 (31 worldwide citation)

Methods and compositions are described for the preparation of alpha-tocopherol vesicles, the bilayers of which comprise a salt form of an organic acid derivative of alpha-tocopherol such as the Tris salt form of alpha-tocopherol hemisuccinate. The method is rapid and efficient and does not require t ...


8
Andrew S Janoff, Lois E Bolcsak, Alan L Weiner, Paul A Tremblay, Michael V W Bergamini: Alpha tocopherol-based vesicles. The Liposome Company, Allen Bloom, Catherine Kurtz, Ilene Janofsky, August 20, 1991: US05041278 (28 worldwide citation)

Methods and compositions are described for the preparation of alpha-tocopherol vesicles, the bilayers of which comprise a salt form of an organic acid derivative of alpha-tocopherol such as the Tris salt form of alpha-tocopherol hemisuccinate. The method is rapid and efficient and does not require t ...


9
John J Kearns, Paul A Tremblay, Raymond J Robey, Swaminathan Sunder: Process for purification of phospholipids. Air Products and Chemicals, Richard A Dannells Jr, William F Marsh, James C Simmons, March 21, 1989: US04814111 (27 worldwide citation)

A process for the separation and purification of individual phospholipids, especially phosphatidylcholine or lecithin and phosphatidylethanolamine, from mixtures containing members of the sub-class of phosphatides, incorporating methods of solvent extraction appropriate to the scale of the sample an ...


10
John J Kearns, Paul A Tremblay: Process for purification of phospholipids. The Liposome Company, Allen Bloom, Catherine L Kurtz, January 28, 1992: US05084215 (21 worldwide citation)

A process for the separation and purification of individual phospholipids, especially phosphatidylcholine or lecithin and phosphatidylethanolaine, from mixtures containing members of the sub-class of phosphatides, incorporating methods of solvent extraction appropriate to the scale of the sample and ...