1
Daniel A Grande, Paul A Lucas: Mesenchymal stem cells for cartilage repair. Morphogen Pharmaceuticals, North Shore University Hospital Research Corporation, Klauber & Jackson, May 25, 1999: US05906934 (380 worldwide citation)

It has been discovered that mesenchymal stem cells (MSCs) in a polymeric carrier implanted into a cartilage and/or bone defect will differentiate to form cartilage and/or bone, as appropriate. Suitable polymeric carriers include porous meshes or sponges formed of synthetic or natural polymers, as we ...


2
Daniel A Grande, Paul A Lucas: Mesenchymal stem cells for cartilage repair. MorphoGen Pharmaceuticals, Klauber & Jackson, April 10, 2001: US06214369 (237 worldwide citation)

It has been discovered that mesenchymal stem cells (MSCs) in a polymeric carrier implanted into a cartilage and/or bone defect will differentiate to form cartilage and/or bone, as appropriate. Suitable polymeric carriers include porous meshes or sponges formed of synthetic or natural polymers, as we ...


3
Henry E Young, Paul A Lucas: Pluripotent mesenchymal stem cells and methods of use thereof. MorphoGen Pharmaceuticals, Klauber & Jackson, October 27, 1998: US05827735 (198 worldwide citation)

A scar inhibitory factor protein isolate from mammalian basement membranes is provided that inhibits lineage commitment and differentiation of stem cells in vitro and in vivo. The protein isolate is characterized by its ability to inhibit stem cell commitment to a fibroblastic-scar phenotype without ...


4
Paul A Lucas: Coffee cup and container. Webster B Harpman, January 16, 1979: US04134492 (41 worldwide citation)

A coffee cup and container for a beverage concentrate comprises an expendible cup and a plastic film liner therefor positioning the beverage concentrate between the liner and the cup bottom. The liner overlaps the rim of the cup and is attached thereto so as to form a convenient easily handled secti ...


5
Cato T Laurencin, Paul A Lucas, Glenn T Syftestad, Abraham Domb, Julie Glowacki, Robert S Langer: Delivery system for controlled release of bioactive factors. Massachusetts Institute of Technology, Arnall Golden & Gregory, May 13, 1997: US05629009 (39 worldwide citation)

A composition and method for controlled release of water-soluble proteins comprising a surface-eroding polymer matrix and water-soluble bioactive factors is described. The composition bioerodes in the biological environment of the subject at a controlled rate, thereby releasing the water soluble pro ...


6
Cato T Laurencin, Paul A Lucas, Glenn T Syftestad, Abraham Domb, Julianne Glowacki, Robert S Langer: Delivery system for controlled release of bioactive factors. Massachusetts Institute of Technology, Kilpatrick & Cody, October 18, 1994: US05356630 (37 worldwide citation)

A composition and method for controlled release of water-soluble proteins comprising a surface-eroding polymer matrix and water-soluble bioactive factors is described. The composition bioerodes in the biological environment of the subject at a controlled rate, thereby releasing the water soluble pro ...


7
Cato T Laurencin, Paul A Lucas, Glenn T Syftestad, Abraham Domb, Julianne Glowacki, Robert S Langer: Delivery system for controlled release of bioactive factors. Massachusetts Institute of Technology, Arnall Golden & Gregory, August 13, 1996: US05545409 (30 worldwide citation)

A composition and method for controlled release of water-soluble proteins comprising a surface-eroding polymer matrix and water-soluble bioactive factors is described. The composition bioerodes in the biological environment of the subject at a controlled rate, thereby releasing the water soluble pro ...


8
Paul A Lucas, Henry E Young, Cato T Laurenchin: Muscle morphogenic protein and use thereof. Massachusetts Institute of Technology, Kilpatrick & Cody, July 12, 1994: US05328695 (30 worldwide citation)

A myogenic protein isolate from mammalian bone is provided that stimulates lineage commitment and differentiation of stem cells in vitro and in vivo. The protein isolate is characterized by its ability to cause muscle stem cell differentiation without excessive proliferation of connective tissue pro ...


9
Kenneth E Ackley, William H Eburn Jr, Paul A Lucas: Square bottomed bag folding apparatus. Mobil Oil Corporation, Charles A Huggett, Michael G Gilman, Charles A Malone, March 9, 1976: US03942416 (7 worldwide citation)

An apparatus for refolding a tapered, transversely sealed, gussetted bag into a gussetted square bottom bag, comprising: opening means whereby the wall portions are formed into distinct walls having a generally rectangular configuration; a rotating main drive assembly; an expandable rectangularly sh ...


10
Paul A Lucas: Snow removing device. Webster B Harpman, March 27, 1979: US04145823 (6 worldwide citation)

A snow removing device has a hollow roller with closely spaced apertures forming its surface through which partially compacted snow moves as the roller advances. A suction blower communicates with the hollow roller to continuously remove snow therefrom and a secondary roller having fingers engagable ...