1
Pau Maria Grazia, Uytdehaag Alphonsus Gerardus C, Schouten Govert Johan: Production of vaccines. Crucell Holland, June 20, 2001: EP1108787-A2 (15 worldwide citation)

Novel means and methods are provided for the production of mammalian viruses, comprising infecting a culture of immortalized human cells with the virus, incubating the culture infected with virus to propagate the virus under conditions that permit growth of the virus, and to form a virus-containing ...


2
Pau Maria Grazia, Holterman Lennart, Kaspers Jorn, Stegmann Antonius Johannes Hendrikus: Recombinant viral-based malaria vaccines. Crucell Holland, Pau Maria Grazia, Holterman Lennart, Kaspers Jorn, Stegmann Antonius Johannes Hendrikus, KLEIN Bart, July 1, 2004: WO/2004/055187 (11 worldwide citation)

The present invention relates to novel vaccines against malaria infections, based on recombinant viral vectors, such as alphaviruses, adenoviruses or vaccinia viruses. The recombinant viral-based vaccines can be applied for immunization against different Plasmodium infections, such as infections by ...


3
Havenga Menzo Jans Emco, Holterman Lennart, Kostense Stefan, Pau Maria Grazia, Sprangers Mieke Caroline, Vogels Ronald: New settings for recombinant adenoviral-based vaccines. Crucell Holland, Havenga Menzo Jans Emco, Holterman Lennart, Kostense Stefan, Pau Maria Grazia, Sprangers Mieke Caroline, Vogels Ronald, KLEIN Bart, May 6, 2004: WO/2004/037294 (4 worldwide citation)

The present invention provides new uses of recombinant adenoviral vectors in vaccination regimens, such as prime-boost set-ups and subsequent vaccinations and applications for gene therapy. Moreover, the invention provides new assays to determine the best regimen for applying the most suitable recom ...


4
Pau Maria Grazia, Goudsmit Jaap, Cohen Joseph D, Dubois Patrice M, Stewart V Ann, Heppner Donald: Malaria prime/boost vaccines. Crucell Holland, Glaxosmithkline Biologicals, The Government Of The United, States Represented By The, Secretary Of The, Army On Behalf Of The, Walter Reed Army Institute Of Research, Pau Maria Grazia, Goudsmit Jaap, Cohen Joseph D, Dubois Patrice M, Stewart V Ann, Heppner Donald, KLEIN Bart, April 20, 2006: WO/2006/040334 (4 worldwide citation)

The invention relates to novel vaccine regimens in which specific prime/boost regimens are applied using low-neutralized recombinant adenoviral vectors harboring nucleic acids encoding antigens from Plasmodium falciparum and purified recombinant protein vaccines such as RTS,S, in the context of appr ...


5
Uytdehaag Alphonsus Gerardus Cornelis Maria, Pau Maria Grazia, Schouten Govert: Production influenza virus vaccines. Crucell Holland, Uytdehaag Alphonsus Gerardus Cornelis Maria, Pau Maria Grazia, Schouten Govert, HATEBOER Guus, April 26, 2007: WO/2007/045674 (4 worldwide citation)

Means and methods for producing mammalian viruses, the method comprising infecting a culture of immortalized human cells with a virus, incubating the culture infected with virus to propagate the virus under conditions that permit growth of t he virus, and to form a virus-containing medium, and remov ...


6
Pau Maria Grazia, Holterman Lennart, Kaspers Jorn, Stegmann Antonius Johannes Hen: Recombinant viral-based malaria vaccines. Crucell Holland, September 14, 2005: EP1573012-A1 (2 worldwide citation)

The present invention relates to novel vaccines against malaria infections, based on recombinant viral vectors, such as alphaviruses, adenoviruses or vaccinia viruses. The recombinant viral-based vaccines can be applied for immunization against different Plasmodium infections, such as infections by ...


7
PAU MARIA GRAZIA, HOLTERMAN LENNART, KASPERS JORN, STEGMANN ANTONIUS JOHANNES HENDRIKUS: VACCINS CONTRE LA MALARIA A BASE VIRALE RECOMBINANTE, RECOMBINANT VIRAL-BASED MALARIA VACCINES. CRUCELL HOLLAND, CRUCELL HOLLAND, BORDEN LADNER GERVAIS, July 2, 2013: CA2507915 (2 worldwide citation)

The present invention relates to novel vaccines against malaria infections, based on recombinant viral vectors, such as alphaviruses, adenoviruses or vaccinia viruses. The recombinant viral-based vaccines can be applied for immunization against different Plasmodium infections, such as infections by ...


8
PAU MARIA GRAZIA, HOLTERMAN LENNART, KASPERS JORN, STEGMANN ANTONIUS JOHANNES HENDRIKUS: [fr] VACCINS CONTRE LA MALARIA BASÉS SUR UN VIRUS RECOMBINANT, [de] REKOMBINANTER VIRUS-BASIERTER MALARIA IMPFSTOFF, [en] RECOMINANT VIRAL-BASED MALARIA VACCINS. CRUCELL HOLLAND, December 8, 2010: EP2258850-A1 (1 worldwide citation)

[en] The present invention relates to novel vaccines against malaria infections, based on recombinant viral vectors, such as alphaviruses, adenoviruses or vaccinia viruses. The recombinant viral-based vaccines can be applied for immunization against different Plasmodium infections, such as infection ...


9
Pau Maria Grazia, Uytdehaag Alphonsus Gerardus C: Production of vaccines from immortalised mammalian cell lines. Introgene, May 30, 2001: EP1103610-A1 (1 worldwide citation)

Novel means and methods are provided for the production of mammalian viruses, comprising infecting a culture of immortalized human cells with the virus, incubating the culture infected with virus to propagate the virus under conditions that permit growth of the virus, and to form a virus-containing ...


10
Sullivan Nancy, Chakrabarti Bimal, Yang Zhi Yong, Pau Maria Grazia, Goudsmit Jaap, Nabel Gary J: Optimized vaccines to provide protection against ebola and other viruses. The Government Of The United States Of, America Represented By, The Secretary Department Of Health And Human Services, Crucell Holland, Sullivan Nancy, Chakrabarti Bimal, Yang Zhi Yong, Pau Maria Grazia, Goudsmit Jaap, Nabel Gary J, ALTMAN Daniel E, April 6, 2006: WO/2006/037038 (1 worldwide citation)

The invention is related to a nucleic acid molecule comprising a polynucleotide encoding a modified filovirus glycoprotein (GP) having at least one amino acid change located in a relatively conserved region of said GP that decreases in vitro cytotoxicity and retains immunogenicity when compared to i ...



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