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Patrick S L Wong, Brian Barclay, Joseph C Deters, Felix Theeuwes: Osmotic device with dual thermodynamic activity. Alza Corporation, Paul L Sabatine, Edward L Mandell, Steven F Stone, September 16, 1986: US04612008 (327 worldwide citation)

An osmotic system is disclosed comprising a wall formed in at least a part of a semipermeable material that surrounds a compartment. The compartment contains a first osmotic composition comprising a beneficial agent, and a second and different osmotic composition. A passageway in the wall connects t ...


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Patrick S L Wong, Brian L Barclay, Joseph C Oeters, Felix Theeuwes: Osmotic system comprising plurality of members for dispensing drug. ALZA Corporation, Paul L Sabatine, Edward L Mandell, Steven F Stone, November 8, 1988: US04783337 (242 worldwide citation)

An osmotic system is disclosed comprising a wall comprising in at least a part of a semipermeable material that surrounds a compartment. The compartment contains a first osmotic composition comprising a beneficial drug selected from the group consisting of a calcium antagonist, angiotensin enzyme in ...


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Patrick S L Wong, Brian L Barclay, Joseph C Deters, Felix Theeuwes: Osmotic device for administering certain drugs. Alza Corporation, Paul L Sabatine, Edward L Mandell, Steven F Stone, August 23, 1988: US04765989 (200 worldwide citation)

An osmotic system is disclosed comprising a wall comprising in at least a part of a semipermeable material that surrounds a compartment. The compartment contains an osmotic composition comprising a beneficial drug selected from the group consisting of nifedipine, prazosin and doxazosin, and a second ...


5
David E Edgren, Shu Li, Gurdish Kaur Bhatti, Patrick S L Wong, Robert R Skluzacek: Extended release dosage form. Alza Corporation, John A Dhuey, Steven F Stone, June 12, 2001: US06245357 (176 worldwide citation)

A dosage form comprising a composition comprising a drug surrounded by an interior and an exterior wall with an exit for administering the drug to a patient; and a method of using the dosage form are disclosed for an indicated therapy.


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Patrick S L Wong, Liang Chang Dong, David E Edgren, Felix Theeuwes, Phyllis I Gardner, Francisco Jao, Jason J Wan: Prolonged release active agent dosage form adapted for gastric retention. ALZA Corporation, John A Dhuey, Steven F Stone, September 19, 2000: US06120803 (150 worldwide citation)

The present invention is directed to an active agent dosage form which is adapted for retention in the stomach and useful for the prolonged delivery of an active agent formulation to a fluid environment of use. The active agent dosage form is a polymer matrix that swells upon contact with the fluids ...


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David E Edgren, Francisco Jao, Patrick S L Wong: Gastric retention dosage form having multiple layers. Alza Corporation, September 28, 2004: US06797283 (103 worldwide citation)

The present invention is directed to a multilayered dosage form which is adapted for retention in the stomach and useful for the prolonged delivery of an active agent to a fluid environment of use. The active agent dosage form is a multilayer core, often bilayer, formed of polymer matrices that swel ...


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Patrick S L Wong, Felix Theeuwes: Aqueous emulsion for pharmaceutical dosage form. Alza Corporation, Paul L Sabatine, Edward L Mandell, Steven F Stone, May 28, 1991: US05019397 (99 worldwide citation)

A dosage form is disclosed comprising a cured emulsion that coat that surrounds a drug. The emulsion comprises a lower alkyl acrylate-lower alkyl methacrylate copolymer and ethyl cellulose. The emulsion optionally comprises a hydrophilic polymer.


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Alejandro Zaffaroni, Patrick S L Wong: Active agent dispenser. ALZA Corporation, Steven F Stone, Paul L Sabatine, Edward L Mandell, January 14, 1986: US04564364 (91 worldwide citation)

The release pattern of a dispersion type active agent dispenser can be improved by forming the device from a depleted zone containing the agent at a concentration no greater than the saturation and a non-depleted zone containing the agent dispersed in the matrix at a uniform concentration greater th ...