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Jacques Y Gauthier, Cheuk K Lau, Yves LeBlanc, Chun Sing Li, Patrick Roy, Michel Therien, Zhaoyin Wang: Aryl substituted 5,5 fused aromatic nitrogen compounds as anti-inflammatory agents. Merck Frosst Canada, Curtis C Panzer, David L Rose, September 3, 1996: US05552422 (167 worldwide citation)

The invention encompasses the novel compound of Formula I as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. ##STR1## The invention also encomp ...


2
Cheuk Kun Lau, Cameron Black, Daniel Guay, Jacques Yves Gauthier, Yves LeBlanc, Patrick Roy, Yves Ducharme, Pierre Hamel: N-benzyl indol-3-yl butanoic acid derivatives as cyclooxygenase inhibitors. Merck Frosst Canada, Curtis C Panzer, David L Rose, June 17, 1997: US05639780 (140 worldwide citation)

The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.


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Cheuk K Lau, Cameron Black, Daniel Guay, Jacques Y Gauthier, Yves LeBlanc, Patrick Roy, Yves Ducharme, Pierre Hamel: N-benzylindol-3-yl propanoic acid derivatives as cyclooxygenase inhibitors. Merck Frosst Canada, Curtis C Panzer, David L Rose, February 18, 1997: US05604253 (136 worldwide citation)

The invention encompasses the novel compound of Formula I as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. ##STR1## The invention also encomp ...


4
W Cameron Black, Chun Sing Li, Daniel Guay, Petpiboon Prasit, Patrick Roy: Alkanesulfonamido-1-indanone derivatives as inhibitors of cyclooxygenase. Merck Frosst Canada, Curtis C Panzer, David L Rose, April 25, 1995: US05409944 (113 worldwide citation)

Disclosed are compounds of Formula I useful in the treatment of cyclooxygenase mediated diseases such as pain, fever and inflammation of a variety of conditions including rheumatic fever, symptoms associated with influenza or other viral infections, common cold, low back and neck pain, dysmenorrhea, ...


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Michel L Belley, Serge Leger, Marc Labelle, Patrick Roy, Yi B Xiang, Daniel Guay: Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists. Merck Frosst Canada, Mollie M Yang, David L Rose, October 15, 1996: US05565473 (37 worldwide citation)

Compounds having the formula I: ##STR1## are leukotriene antagonists and inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, h ...


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Michel Belley, Jacques Yves Gauthier, Erich Grimm, Yves LeBlanc, Chun Sing Li, Michel Therien, Cameron Black, Petpiboon Prasit, Cheuk Kun Lau, Patrick Roy: (Methylsulfonyl)phenyl-2-(5H)-furanones as COX-2 inhibitors. Merck Frosst Canada, Richard C Billups, David L Rose, February 1, 2000: US06020343 (25 worldwide citation)

The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.


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Michel L Belley, Serge Leger, Patrick Roy, Yi B Xiang, Marc Labelle: Saturated hydroxyalkylquinoline acids as leukotriene antagonists. Merck Frosst Canada, Mollie M Yang, David L Rose, June 27, 1995: US05428033 (19 worldwide citation)

Compounds having the formula I: ##STR1## are leukotriene antagonists and inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, h ...


9
Michel L Belley, Serge Leger, Patrick Roy, Marc Labelle, Yi Bin Xiang, Daniel Guay: Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists. Merck Frosst Canada, Mollie M Yang, David L Rose, January 5, 1999: US05856322 (10 worldwide citation)

Compounds having the formula I: ##STR1## are leukotriene antagonists and inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, h ...


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