1
William H Gmeiner, Patrick L Iversen: Oligonucleotides containing 5-fluorouracil. Board of Regents University of Nebraska, Henderson & Sturm, October 10, 1995: US05457187 (265 worldwide citation)

A homo-oligonucleotide of between 2 and 26 monomers of 5-fluorouridine 5'-monophosphate or 5-fluorodeoxyuridine 5'-monophosphate covalently linked via 3'- to 5'-phosphodiester linkages, where at the 3'- or 5'- terminus there is covalently linked a molecule selected from the group consisting of chole ...


2
Patrick L Iversen: Antisense antibacterial method and composition. AVI BioPharma, Linda R Judge, LeeAnn Gorthey, Perkins Coie, January 13, 2004: US06677153 (93 worldwide citation)

The invention relates to compositions comprising oligomers antisense to bacterial 16S or 23S rRNA and capable of selectively modulating the biological activity thereof, and methods for their use. More particularly, the invention relates to antisense oligomers directed to 16S or 23S rRNA found in one ...


3
Patrick L Iversen, Hemant K Roy, Richard K Bestwick: Antisense composition and method for treating cancer. AVI BioPharma, King & Spalding, July 22, 2008: US07402574 (78 worldwide citation)

A method and composition for treating colorectal cancer is disclosed. The method involves administering to a subject, a therapeutically effective amount of a morpholino antisense compound (i) having a nuclease-resistant backbone, (ii) capable of uptake by target cancer cells in the subject, (iii) co ...


4
Patrick L Iversen, Robert Hudziak: Splice-region antisense composition and method. AVI BioPharma, LeeAnn Gorthey, Perkins Coie, August 31, 2004: US06784291 (74 worldwide citation)

Antisense compositions targeted against an mRNA sequence coding for a selected protein, at a region having its 5′ end from 1 to about 25 base pairs downstream of a normal splice acceptor junction in the preprocessed mRNA, are disclosed. The antisense compound is RNase-inactive, and is preferably a p ...


5
Patrick L Iversen, Hong M Moulton, Michelle H Nelson, Andrew D Kroeker, David A Stein: Compositions for enhancing transport of molecules into cells. AVI BioPharma, King & Spalding, December 23, 2008: US07468418 (58 worldwide citation)

Compositions and methods for enhancing delivery of molecules, e.g. biological agents, into cells are described. The composition is a conjugate of the biological agent, preferably a nucleic acid analog having a substantially uncharged backbone, covalently linked to a peptide transporter moiety as des ...


6
Patrick L Iversen, Dwight D Weller: Antisense restenosis composition and method. AVI BioPharma, Perkins Coie, August 22, 2006: US07094765 (57 worldwide citation)

The present invention provides an improved method for reducing the risk or severity of restenosis following cardiac angioplasty. The method includes administering to a target vessel region, a morpholino antisense compound having uncharged phosphorus-containing backbone linkages, and spanning the sta ...


7
Stephen H Bartelmez, Patrick L Iversen: Transforming growth factor beta (TGF-β) blocking agent-treated stem cell composition and method. AVI BioPharma, Perkins Coie, January 11, 2005: US06841542 (53 worldwide citation)

The invention relates to TGF-β blocking agent-treated HSC compositions and methods comprising the same. The TGF-β blocking agent-treated stem cells are viable for an extended time in culture without replication or differentiation and upon transfer to appropriate conditions are capable of long term h ...


8
Thomas R Porter, Patrick L Iversen: Compositions and methods for altering the biodistribution of biological agents. Board of Regents of the University of Nebraska, Zarley McKee Thomte Voorhees & Sease, December 15, 1998: US05849727 (49 worldwide citation)

This invention relates to a new and improved pharmaceutical composition and method for delivery of therapeutic or bioactive agents. The methods and composition of the invention can be used with several therapeutic or bioactive agents and can achieve site-specific delivery of a therapeutic or biologi ...


9
Patrick L Iversen: Non-invasive method for detecting target RNA. AVI BioPharma, Linda R Judge, Perkins Coie, April 2, 2002: US06365351 (49 worldwide citation)

The present invention provides a method for targeting a particular mRNA sequence in vivo by oral administration of a morpholino antisense compound having uncharged phosphorus-containing backbone linkages. Also disclosed is a non-invasive method of detecting and quantitating the in vivo presence of R ...


10
David A Stein, Douglas E Skilling, Patrick L Iversen, Alvin W Smith: Antisense antiviral agent and method for treating ssRNA viral infection. AVI BioPharma, Peter J Dehlinger, Lee Ann Gorthey, Perkins Coie, December 7, 2004: US06828105 (49 worldwide citation)

The invention provides antisense antiviral compounds and methods of their use in inhibition of growth of viruses of the picornavirus, calicivirus, togavirus and flavivirus families, as in treatment of a viral infection. The antisense antiviral compounds are substantially uncharged oligomers having a ...