1
Patrick E Guire: Method of improving the biocompatibility of solid surfaces. Bio Metric Systems, James R Bauman Mary P Haller, Gregory P Kaihoi, November 27, 1990: US04973493 (313 worldwide citation)

A method for modifying the solid surface to improve its biocompatibility is disclosed. The method employs molecules of a biocompatible agent and a chemical linking moiety possessing a photochemically reactive group capable upon activation of covalently bonding to the solid surface and possessing a d ...


2
Patrick E Guire: Biocompatible coating for solid surfaces. Bio Metric Systems, James R Haller, Mary P Bauman, Gregory P Kaihoi, December 25, 1990: US04979959 (253 worldwide citation)

The biocompatibility of biomaterials having solid surfaces is improved through coating the same with biocompatible agents where the biocompatible agents are covalently bonded to the solid surface via a chemical linking moiety. The method for modifying the solid surface to improve biocompatibility em ...


3
Patrick E Guire, Shawn G Dunkirk, Mark W Josephson, Melvin J Swanson: Preparation of polymeric surfaces via covalently attaching polymers. Bio Metric Systems, James R Haller, Gregory P Kaihoi, Mary P Bauman, March 26, 1991: US05002582 (232 worldwide citation)

A method wherein surfaces are provided with desired characteristics of a polymer by covalently bonding polymer molecules to the surface through external activation of latent reactive groups carried by the polymer molecules is disclosed. The initial surfaces are free of chemical groups added by surfa ...


4
Patrick E Guire: Biocompatible device with covalently bonded biocompatible agent. Bio Metric Systems, Fredrikson & Byron, November 23, 1993: US05263992 (190 worldwide citation)

The biocompatibility of biomaterials having solid surfaces is improved through coating the same with biocompatible agents. The method for modifying the solid surface to improve biocompatibility employs molecules of a biocompatible agent and a chemical linking moiety possessing a photochemically reac ...


5
Patrick E Guire: Binding reagents and methods. Bio Metric Systems, James R Haller, Mary P Bauman, February 2, 1988: US04722906 (178 worldwide citation)

A method for selectively covalently linking a target moiety to a chemical moiety or carrier comprising attaching to the chemical moiety or carrier a reagent having a selector group capable of forming a specific bond with a receptor carried on the target moiety and attaching a latent reactive group w ...


6
Melvin J Swanson, Patrick E Guire: Quantitative analysis apparatus and method. Bio Metric Systems, Fredrikson & Byron, December 17, 1991: US05073484 (161 worldwide citation)

A method and apparatus for the quantitative determination of an analyte in a liquid employs a liquid-permeable solid medium defining a liquid flow path. The medium includes a number of reaction-containing reaction zones spaced apart along the flow path and in which reaction occurs with the analyte o ...


7
Patrick E Guire, Stephen J Chudzik: Field assay for ligands. Bio Metric Systems, Mary P Bauman, James R Haller, Gregory P Kaihoi, May 2, 1989: US04826759 (153 worldwide citation)

Apparatuses and methods are disclosed which can be used in the field (i.e., outside the laboratory environment) to determine qualitatively and at least semiquantitatively the presence or absence of minute quantities of ligand. The apparatus can be in the form of a strip comprising a support means pr ...


8
Patrick E Guire, Kristin S Taton, John V Wall: Particle immobilized coatings and uses thereof. Surmodics, Kagan Binder PLLC, March 25, 2014: US08679454 (126 worldwide citation)

Surface coatings including microparticles immobilized in a matrix of polymeric material on a substrate are described. The microparticles can also include an agent which can be useful for various applications, such as medical applications. This invention relates to the field of surface coatings for u ...


9
Ralph A Chappa, Sheau Ping Hu, Dale G Swan, Melvin J Swanson, Patrick E Guire: Target molecule attachment to surfaces. Surmodics, Merchant & Gould P C, October 15, 2002: US06465178 (126 worldwide citation)

Method and reagent composition for covalent attachment of target molecules, such as nucleic acids, onto the surface of a substrate. The reagent composition includes groups capable of covalently binding to the target molecule. Optionally, the composition can contain photoreactive groups for use in at ...


10
Patrick E Guire, Kristin S Taton: Self assembling monolayer compositions. SurModics, Fredrikson & Byron P A, February 10, 2004: US06689473 (100 worldwide citation)

A surface coating composition for providing a self-assembling monolayer, in stable form, on a material surface or at a suitable interface, as well as a method of preparing such a composition and a method of using such a composition to coat a surface, such as the surface of an implantable medical dev ...



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