1
Patrick Aebischer, Shelley R Winn, Pierre M Galletti: In vivo delivery of neurotransmitters by implanted, encapsulated cells. Brown University Research Foundation, Thomas J Engellenner, Ann Louise Kerner, January 9, 1990: US04892538 (319 worldwide citation)

Methods and devices are disclosed for the delivery of a neurotransmitter from an implanted, neurotransmitter-secreting cell culture to a target region in a subject. The cell culture is maintained within a biocompatible, semipermeable membrane which permits the diffusion of the neurotransmitter there ...


2
Keith E Dionne, Dwaine F Emerich, Diane Hoffman, Paul R Sanberg, Lisa Christenson, Orion D Hegre, David W Scharp, Paul E Lacy, Patrick Aebischer, Alfred V Vasconcellos, Michael J Lysaght, Frank T Gentile: Implantable biocompatable immunoisolatory vehicle for delivery of selected therapeutic products. Brown University Research Foundation, Brown University, Ivor R Elrifi, John Prince, Mintz Levin Cohn Ferris Glovsky and Popeo P C, July 4, 2000: US06083523 (288 worldwide citation)

An immunoisolatory vehicle for the implantation into an individual of cells which produce a needed product or provide a needed metabolic function. The vehicle is comprised of a core region containing isolated cells and materials sufficient to maintain the cells, and a permselective, biocompatible, p ...


3
Patrick Aebischer, Pierre M Galletti, George Panol, Luigi Miracoli: Implantable delivery system for biological factors. Brown University Research Foundation, Thomas J Engellener, April 30, 1991: US05011472 (209 worldwide citation)

Devices and methods are disclosed to provide hybrid, modular systems for the constitutive delivery of appropriate dosages of active factor to a subject and, in some instances, to specific anatomical regions of the subject. The systems include a cell reservoir containing living cells capable of secre ...


4
Patrick Aebischer, Paul C DiCesare, Moses Goddard, Paul J Mulhauser: Renewable neural implant device and method. Brown University Research Foundation, James F Haley Jr Esq, Ivor R Fish & Neave Elrifi Esq, September 10, 1996: US05554148 (206 worldwide citation)

Refillable immunoisolatory neurological therapy devices for local and controlled delivery of a biologically active factor to the brain of a patient. The devices include a cell chamber adapted for infusion with nsecretory cells and having at least one semipermeable or permselective surface across whi ...


5
Patrick Aebischer, Moses Goddard, John G Moldauer, Paul J Mulhauser, Anne M Rathbun, Paul R Sanberg, Alfred V Vasconcellos, Nicholas F Warner: Implantable therapy systems and methods. Brown University Research Foundation, Ivor R Elrifi, Barbara A Ruskin, Fish & Neave, January 30, 1996: US05487739 (166 worldwide citation)

Implantable therapy systems are disclosed for the local and controlled delivery of a biologically active factor to the brain, spinal cord and other target regions of a subject suffering from a debilitating condition. The method of the invention involves surgically exposing an insertion site, general ...


6
Patrick Aebischer, Shelley R Winn: Neurological therapy devices. Brown University Research Foundation, Thomas J Engellenner, Ann Louise Kerner, April 21, 1992: US05106627 (166 worldwide citation)

Neurological therapy devices are disclosed for the local and controlled delivery of a neurotransmitter to the brain of a subject suffering from neurotransmitter deficiency or dysfunction. In one embodiment the device includes a biocompatible, implantable, and retrievable polymeric insert including a ...


7
Patrick Aebischer, Lars Wahlberg: Cell culture-containing tubular capsule produced by co-extrusion. Brown University Research Foundation, Thomas J Engellenner, Matthew P Vincent, February 1, 1994: US05283187 (127 worldwide citation)

Living cells such as animal cells which produce biologically active factors are encapsulated within a semipermeable, polymeric membrane such as polyacrylate by co-extruding an aqueous cell suspension and a polymeric solution through a common port having at least one concentric bores to form a tubula ...


8
Patrick Aebischer, Lars Wahlberg: Method and system for encapsulating cells in a tubular extrudate in separate cell compartments. Brown University Research Foundation, Thomas J Engellenner, October 27, 1992: US05158881 (106 worldwide citation)

Methods and systems are disclosed for encapsulating viable cells which produce biologically-active factors. The cells are encapsulated within a semipermeable, polymeric membrane by co-extruding an aqueous cell suspension and a polymeric solution through a common port to form a tubular extrudate havi ...


9
Patrick Aebischer, Patrick A Tresco: Implanting devices for the focal release of neuroinhibitory compounds. Brown University Research Foundation, Flehr Hohbach Test Albritton & Herbert, December 12, 1995: US05474547 (91 worldwide citation)

Methods are disclosed for the alleviation of movement disorders via the implantation of static devices which focally release neuroinhibitory compounds to preselected brain areas. Pathological conditions to be treated by these methods include parkinsonian movement disorders, Huntington's chorea, and ...


10
Keith E Dionne, Dwaine F Emerich, Diane Hoffman, Paul R Sanberg, Lisa Christenson, Orion D Hegre, David W Scharp, Paul E Lacy, Patrick Aebischer, Alfred V Vasconcellos, Michael J Lysaght, Frank T Gentile: Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products. Brown University Research Foundation, Ivor R Mintz Levin Elrifi, September 1, 1998: US05800828 (89 worldwide citation)

Immunoisolatory vehicles having a core and a surrounding jacket are disclosed, the core having a volume in excess of 1 .mu.l and at least about 10.sup.4 living cells capable of secreting a biologically active product or of providing a biological function to a patient, the cells dispersed in a biocom ...