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Maeda Tadao, Saperstein David, Palczewski Krzysztof: Methods for the treatment and prevention of age-related retinal dysfunction. University Of Washington, Maeda Tadao, Saperstein David, Palczewski Krzysztof, O SHAUGHNESSY Brian P, August 20, 2009: WO/2009/102418 (3 worldwide citation)

ABSTRACT A method of treating or preventing age-related retinal dysfunction involves administering to a patient a pharmaceutically effective amount of a synthetic retinal derivative repeatedly over a duration of at least about 3 months. Effective synthetic retinal derivatives include 9-cis-retinyl e ...


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MAEDA TADAO, SAPERSTEIN DAVID, PALCZEWSKI KRZYSZTOF: PROCEDES POUR LE TRAITEMENT ET LA PREVENTION DUN DYSFONCTIONNEMENT RETINIEN LIE A LAGE, METHODS FOR THE TREATMENT AND PREVENTION OF AGE-RELATED RETINAL DYSFUNCTION. UNIVERSITY OF WASHINGTON, UNIVERSITY OF WASHINGTON, NORTON ROSE FULBRIGHT CANADA S E N C R L S R L, September 25, 2018: CA2714530 (2 worldwide citation)

There is described herein the use of a pharmaceutically effective amount of a synthetic retinal derivative, or use of the same in the preparation of a medicament, for oral administration to a human subject for the treatment or prevention of age-related impairment in rod-mediated dark adaptation afte ...


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Palczewski Krzysztof, Moise Radu A: Compositions and methods for treating metabolic diseases. Case Western Reserve, University, Palczewski Krzysztof, Moise Radu A, SUTKUS Richard A, May 29, 2008: WO/2008/063768 (1 worldwide citation)

A pharmaceutical composition for treating a metabolic disease in a mammalian subject includes a therapeutically effective amount of all-trans-13,14-dihydroretinoid, all-trans-13,14-dihydroretinoid derivative, or agent capable of modulating the level of at least one all-trans-13,14-dihydroretinoid or ...


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Palczewski Krzysztof, Batten Matthew: Retinal derivatives and methods for the use thereof for the treatment of visual disorders. Univ Washington, March 28, 2007: EP1765322-A2

Compositions of and methods for using synthetic retinal derivatives as retinoid replacements and opsin agonists are provided.


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Palczewski Krzysztof, Saperstein David A: Retinoid replacements and opsin agonists and methods for the use thereof. Univ Washington, January 4, 2006: EP1610772-A2

Compositions of and methods for using synthetic retinoids as retinoid replacements and opsin agonists are provided.


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Palczewski Krzysztof, Li Ning, Ballesteros Juan: Expression of polypeptides in rod outer segment membranes. Novasite Pharmaceuticals, September 1, 2004: EP1451296-A2

The invention provides a gene targeting construct containing a transgene encoding a polypeptide that contains a rod outer segment (ROS) targeting signal. The transgene is flanked by 5' and 3' DNA sequences that are homologous to the rhodopsin gene. Homologous recombination between the construct and ...


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Miyano Masashi, Palczewski Krzysztof, Kumasaka Takashi, Hori Tetsuya, Behnke Craig A, Motoshima Hiroyuki, Fox Brain A, Le Trong Isolde, Teller David C, Okada Tetsuji, Stenkamp Ronald E, Yamamoto Masaki: Three-dimensional structure of bovine rhodopsin. Riken, Univ Washington, April 10, 2002: EP1195383-A2

The present invention discloses a three-dimensional structure of bovine rhodopsin. There is provided a G protein-coupled receptor selected from the group consisting of the following (a) and (b): (a) a G protein-coupled receptor having three-dimensional structure I defined by the atomic coordinates a ...


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